Avantera Elevate Drug Interaction Concerns
Learn about potential interactions between +Elevate and Trintellix or lamotrigine, including ingredient-specific risks and pharmacist-reviewed guidance.
How does Avantera Elevate interact with Lamotrigine and Trintellix?
Jul 06, 2026- Avantera Elevate contains ingredients that may have minor to moderate interactions with your Trintellix and lamotrigine, including black pepper extract potentially increasing Trintellix levels and L-theanine potentially affecting serotonin activity or sedation. While no major interactions were identified, you should discuss taking this supplement with your doctor or pharmacist before starting it. The HelloPharmacist Drug-Supplement Interactions directory can help you check your specific medications against Elevate's ingredients.
Hello!
We have this supplement in our Drug-Supplement Interactions directory, and we highly encourage you to check it out! You can find it here: +Elevate: Ingredients, Label & Drug Interactions | HelloPharmacist.
All of our supplement pages include an AI-powered search box that looks like this:
Simply enter your medication(s), and our system will review only the verified interactions in our supplement database to provide you with detailed, ingredient-specific results. This is not a general AI search. It is trained and backed only using our data.
We went ahead and checked Trintellix (vortioxetine) and lamotrigine, and here is what our system found:
Since +Elevate is a multi-ingredient formula, I checked each of its ingredients against both Trintellix (vortioxetine) and lamotrigine.
For Trintellix (vortioxetine), two ingredients were identified as having potential interactions:
- BioPerine (black pepper extract) has a moderate interaction because it may inhibit the CYP2D6 enzyme, potentially increasing vortioxetine levels in the body.
- Suntheanine (L-theanine) has a minor interaction because it may influence serotonin activity. Since vortioxetine also affects the serotonin system, there is a theoretical interaction, although no reports of serious serotonin-related complications from L-theanine have been documented.
For lamotrigine, one ingredient was identified:
- Suntheanine (L-theanine) has a minor interaction because it may have mild sedative or GABA-related effects that could theoretically increase the sedating effects of lamotrigine.
Overall, we did not identify any major interactions. However, because there are several minor to moderate potential interactions involving two prescription medications, it is still a good idea to discuss this supplement with your doctor or pharmacist before starting it.
Final Thoughts
I hope this answer was helpful! Thanks again for using HelloPharmacist.
References & sources
Glossary — Terms in This Answer
- Drug-Supplement Interactions
- A database or reference that documents how medications and supplements may affect each other when taken together.
- CYP2D6 enzyme
- A protein in your body that breaks down many medications; if inhibited, drugs may stay in your system longer at higher levels.
- BioPerine
- An extract from black pepper that can affect how your body processes certain medications.
- Vortioxetine
- The active medication in Trintellix, used to treat depression by affecting serotonin in the brain.
- Suntheanine
- A form of the amino acid L-theanine, an ingredient that may influence brain chemistry and relaxation.
- Serotonin
- A chemical messenger in the brain that affects mood, sleep, and other functions.
- GABA-related effects
- Effects related to a calming brain chemical that can promote relaxation and reduce anxiety.
- Lamotrigine
- A prescription medication used to treat seizures and mood disorders that can cause drowsiness as a side effect.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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