Medication interaction hub

What Supplements Interact with Lamotrigine?

Lamotrigine brand name: Lamictal. Every interaction below applies to the brands too.

116 Interactions 7 Major 92 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lamotrigine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lamotrigine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol, ordinary beer or wine, sits at the top of the interaction list for lamotrigine (Lamictal), with well-documented added sedation, and it sets the tone for a list I would treat with real care. Of the 116 supplements and herbs on file, 78 have sedative effects of their own, so the biggest theme by far is stacked drowsiness and slowed reflexes on top of a drug that can already cause both. Seven entries rate major, and those are the ones to understand first; GHB and kava are among them.

The 92 moderate entries pull in a different direction. Coffee, regular or decaf, has been shown to lower lamotrigine blood levels, and cabbage or Brussels sprouts may speed its clearance too. Since lamotrigine is holding seizures or mood episodes at bay, quiet weakening matters as much as extra sedation. Bulky fibers like glucomannan can also cut absorption of oral doses, so space them well apart.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 92 Minor 17 No known interaction 1,336

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lamotrigine: Top Interactions at a Glance

The Lamotrigine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 116 interacting ingredients — plus 1,336 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lamotrigine Combinations Today

The Lamotrigine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ashwagandha + Lamotriginei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Milk Thistle + Lamotriginei

Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Read the full interaction Minor Likelihood Unlikely Theanine + Lamotriginei

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Read the full interaction Moderate Likelihood Possible Passion Flower + Lamotriginei

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Read the full interaction Moderate Likelihood Possible Saffron + Lamotriginei

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Read the full interaction Moderate Likelihood Possible Dandelion + Lamotriginei

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Lamotrigine

All 1,452 ingredients in our database, ranked by severity — 116 with a Lamotrigine interaction on file and 1,336 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lamotrigine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Lamotrigine answer

Can you take Milk Thistle with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Lamotrigine answer

Can you take Theanine with Lamotrigine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Full Theanine + Lamotrigine answer

Can you take Passion Flower with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Lamotrigine answer

Can you take Saffron with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Lamotrigine answer

Can you take Sage with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Lamotrigine answer

Can you take Sassafras with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Lamotrigine answer

Can you take Sceletium with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Lamotrigine answer

Can you take Shepherd's Purse with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Lamotrigine answer

Can you take Skullcap with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Lamotrigine answer

Can you take Slippery Elm with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Lamotrigine answer

Can you take Spearmint with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Lamotrigine answer

Can you take Tarragon with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Lamotrigine answer

Can you take Theacrine with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Lamotrigine answer

Can you take Thuja with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contain thujone, which might lower the seizure threshold.

Full Thuja + Lamotrigine answer

Can you take Tianeptine with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Lamotrigine answer

Can you take Tragacanth with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Lamotrigine answer

Can you take Tree Turmeric with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Lamotrigine answer

Can you take Uva Ursi with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Lamotrigine answer

Can you take Valerian with Lamotrigine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Lamotrigine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lamotrigine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lamotrigine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lamotrigine sits in 5 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Lamotrigine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lamotrigine through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Lamotrigine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Lamotrigine through this category.

Lamotrigine (Lamictal) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lamotrigine through this category.

About Lamotrigine

Lamotrigine is an anticonvulsant medication used to treat seizures in epilepsy and to help prevent mood episodes in bipolar disorder.

Generic name: Lamotrigine  ·  Brand name: Lamictal.

See the full Lamotrigine drug information

Related: does Lamotrigine deplete any nutrients?

Lamotrigine has 1 reported nutrient association in the research literature — see the Lamotrigine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lamotrigine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lamotrigine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Lamotrigine & Supplements: Common Questions

What supplements interact with Lamotrigine?
Our database currently documents 116 ingredients with a known Lamotrigine interaction (7 major, 92 moderate, 17 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 116. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Lamotrigine supplement interactions are the most serious?
The 7 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lamotrigine?
Plenty of supplements coexist fine with Lamotrigine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Lamictal have the same supplement interactions as Lamotrigine?
Yes — Lamictal all contain Lamotrigine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lamotrigine deplete any vitamins or nutrients?
It might — Lamotrigine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lamotrigine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lamotrigine and my other medications?
This page covers Lamotrigine against supplements and herbal ingredients. Checking Lamotrigine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lamotrigine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.