Vitamin B6 + Lamotrigine
Lamotrigine brand name: Lamictal.
We found no known interaction between Vitamin B6 and Lamotrigine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Vitamin B6 and Lamotrigine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lamotrigine and Vitamin B6 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Vitamin B6 safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Lamotrigine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Lamotrigine is filed under 5 classifications — including anticonvulsants, glucuronidated drugs, cns depressants. Vitamin B6 has documented interactions with 5 drug classes — the most serious being amiodarone (cordarone) (moderate), antihypertensive drugs (moderate) and phenobarbital (luminal) (moderate) — and none of Lamotrigine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Vitamin B6 Does Interact With Other Medications
Vitamin B6 has 205 moderate, 5 minor known drug interactions in our database — Lamotrigine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Vitamin B6
We haven’t checked that one against Vitamin B6 yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Vitamin B6. Pick one to open its full report.
Vitamin B6 in Pregnancy & Breastfeeding
When used orally and appropriately. A special sustained-release product providing vitamin B6 (pyridoxine) 75 mg daily is FDA-approved for use in pregnancy. Vitamin B6 (pyridoxine) is also considered a first-line treatment for nausea and vomiting in pregnancy by the American College of Obstetrics and Gynecology. However, it should not be used long-term or without medical supervision and close monitoring. The tolerable upper intake level (UL) refers to vitamin B6 in the form of pyridoxine and is 80 mg daily for those aged 14-18 years and 100 mg daily for 19 years and older.
When used orally in excessive doses. There is some concern that high-dose maternal vitamin B6 (pyridoxine) can cause neonatal seizures.
When used orally in doses not exceeding the tolerable upper intake level (UL) of vitamin B6 in the form of pyridoxine 80 mg daily for those aged 14-18 years and 100 mg daily for those 19 years and older. The recommended dietary allowance (RDA) in lactating women is 2 mg daily. There is insufficient reliable information available about the safety of vitamin B6 when used in higher doses in breast-feeding women.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Lamotrigine Is Prescribed For, and What Vitamin B6 Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Lamotrigine is a prescription medicine with approved uses on its FDA label. Vitamin B6 is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Lamotrigine is prescribed for: Lamotrigine is used to treat several types of seizures in adults and children aged 2 and older — including partial-onset seizures, generalized tonic-clonic (grand mal) seizures, and seizures related to Lennox-Gastaut syndrome. In older teens and adults, it can also be used alone (monotherapy) after transitioning off another seizure medicine. For adults with bipolar I disorder, lamotrigine is used as a maintenance treatment — meaning it helps delay the return of mood episodes like depression, mania, or mixed states. It is not approved to treat an active manic or mixed episode that's happening right now.
Vitamin B6 has been studied for:
-
Depression studied, not established Vitamin B6 has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Vitamin B6 for depression
It is unclear if oral vitamin B6 reduces the risk of developing depression or improves symptoms of depression.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Lamotrigine on your own; if you are taking Vitamin B6 for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Vitamin B6 or Lamotrigine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Vitamin B6 or Lamotrigine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Avantera Elevate Drug Interaction Concerns ›
- Accidentally Took Two Seroquel During The Day Instead Of One ›
- Is Dandelion Safe With Gabapentin And Lamotrigine? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Lamotrigine
This page covers Vitamin B6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lamotrigine page lists 116 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 92 moderate · 17 minor.
From our pharmacist’s overview on the Lamotrigine page
“Alcohol, ordinary beer or wine, sits at the top of the interaction list for lamotrigine (Lamictal), with well-documented added sedation, and it sets the tone for a list I would treat with real care. Of the 116 supplements and herbs on file, 78 have sedative effects of their own, so the biggest theme by far is stacked drowsiness and slo…”
Reviewed by 2 · Jul 18, 2026
Taking Vitamin B6 as Part of a Dietary Supplement Product? Check It for Interactions
We hold 24,838 real supplement products containing Vitamin B6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin B6. Even though Vitamin B6 itself has no known interaction with Lamotrigine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Vitamin B6 and Lamotrigine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#3 of 1,452 supplements looked up here in the last 7 days
#32 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin B6 reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vitamin B6 and Lamotrigine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Vitamin B6
What is Vitamin B6?
- Morning sickness in pregnancy
- Premenstrual syndrome (PMS)
- Preventing or treating B6 deficiency
- Nerve health and metabolism support
- Nausea
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-related nausea and may help some people with PMS, but taking very high doses for long periods can cause nerve damage. Get most of your B6 from food, and check with a pharmacist or doctor before taking high-dose supplements.
Tablets, capsules, softgels, liquid drops, part of B-complex and multivitamins
An interaction check asks whether these two react with each other — it does not ask whether Vitamin B6 is a good idea for someone in your situation. Here is what our Vitamin B6 record says about it on its own.
Vitamin B6: dosing
There is no single "best" supplement dose for everyone, and the right amount depends on your age, health, and the reason you are taking it. Health authorities set recommended daily intakes and an upper limit to help avoid nerve-related side effects from too much.The safest approach is to follow the directions on the product label and not exceed the upper limit unless a healthcare provider tells you to. Avoid taking high-dose B6 for long periods on your own.If you take a B-complex or multivitamin, check how much B6 it already contains so you do not accidentally take too much from multiple products.
From our Vitamin B6 monograph — the full record covers uses, side effects and every documented interaction.
About Lamotrigine
What Is Lamotrigine Used For?
Brand name: Lamictal
Lamotrigine is used to treat several types of seizures in adults and children aged 2 and older — including partial-onset seizures, generalized tonic-clonic (grand mal) seizures, and seizures related to Lennox-Gastaut syndrome. In older teens and adults, it can also be used alone (monotherapy) after transitioning off another seizure medicine.
For adults with bipolar I disorder, lamotrigine is used as a maintenance treatment — meaning it helps delay the return of mood episodes like depression, mania, or mixed states. It is not approved to treat an active manic or mixed episode that's happening right now.
Other Drugs & Vitamin B6
Browse every other medication we’ve checked against Vitamin B6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
205 interactions
- Diltiazem ›
- Nifedipine ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Phenytoin ›
- Hydralazine ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Phenobarbital ›
- Prazosin ›
- Spironolactone ›
- Timolol ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Amiodarone ›
- Atenolol ›
- Betaxolol ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorthalidone ›
- Cyclothiazide ›
- Enalapril Maleate ›
- Felodipine ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
- Methyclothiazide ›
- Methyldopa ›
- Metoprolol ›
- Nadolol ›
- Nebivolol ›
- Nimodipine ›
- Olmesartan Medoxomil ›
- Oxprenolol ›
- Pindolol ›
- Quinapril ›
- Reserpine ›
- Terazosin ›
- Torsemide ›
- Treprostinil (oral) ›
- Valsartan ›
- Aliskiren ›
- Amlodipine ›
- Amlodipine Benzoate ›
- Amlodipine Besilate ›
- Amlodipine Besylate ›
- Ammonium Chloride ›
- Aprocitentan ›
Showing 60 of 205 moderate interactions — see all 205 on the Vitamin B6 page.
5 interactions
No interaction 2,619 drugs checked — show the list
We also checked Vitamin B6 against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Cephalexin ›
- Roxithromycin ›
Showing the 60 most looked-up of 2,619 medications checked with no known interaction — see the full Vitamin B6 list.
Vitamin B6 References
The 32 references that drive our Vitamin B6 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
- South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
- Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
- Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
- Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
- Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
- Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
- Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
- Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
- Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
- Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
- Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
- Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
- de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
- Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
- Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
- Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
- Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
- Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
- Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
- Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
- Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
- Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
- Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
- Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
- Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Lamotrigine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Lamotrigine as a medicine that can lower these. This is not an interaction with Vitamin B6 — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Lamotrigine nutrient depletion report ›
Vitamin B6 is itself a nutrient we track — see which medications may deplete VITAMIN B6.
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Vitamin B6 and Lamotrigine Together: Common Questions
Is it safe to take Vitamin B6 with Lamotrigine?
Do Vitamin B6 and Lamotrigine have any of the same side effects?
Are Vitamin B6 and Lamotrigine used for the same thing?
How was the Vitamin B6 and Lamotrigine combination checked?
Does Vitamin B6 interact with any other medications?
Does Lamotrigine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Lamotrigine and Vitamin B6?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.