Drug & supplement interaction

Copaiba Balsam + Lamotrigine

Lamotrigine brand name: Lamictal.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Copaiba Balsam and Lamotrigine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Copaiba Balsam and Lamotrigine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lamotrigine and Copaiba Balsam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Copaiba Balsam at all — not against Lamotrigine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Copaiba Balsam safety at a glance

Copaiba Balsam overall Use caution Generally tolerated in small amounts but human safety data are limited, especially for concentrated oral oil.
Pregnancy Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lamotrigine and Copaiba Balsam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Copaiba Balsam and Lamotrigine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tremor or shakiness Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam in repeated doses of 5 grams or more has been reported to cause shivering, tremor, and insomnia (18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

  • Trouble sleeping Additional detail

    Copaiba Balsam

    Recorded for Copaiba Balsam in the same Natural Medicines adverse-effect record shown under Tremor or shakiness above.

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam in single doses of 5 grams or more has been reported to cause stomach pain, vomiting, and diarrhea (11,18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

  • A skin rash Additional detail

    Copaiba Balsam

    “When applied topically, copaiba balsam can cause contact dermatitis with erythema, a papular or vesicular rash, urticaria, and petechiae. The rash may leave brown spots after healing (18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

Reported for Copaiba Balsam but not commonly for Lamotrigine: hives, bleeding or bruising and chills.

Effects for Lamotrigine come from the ADVERSE REACTIONS section of its FDA label; effects for Copaiba Balsam come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Copaiba Balsam in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Copaiba Balsam or Lamotrigine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Copaiba Balsam or Lamotrigine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lamotrigine

This page covers Copaiba Balsam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lamotrigine page lists 116 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 92 moderate · 17 minor.

From our pharmacist’s overview on the Lamotrigine page

“Alcohol, ordinary beer or wine, sits at the top of the interaction list for lamotrigine (Lamictal), with well-documented added sedation, and it sets the tone for a list I would treat with real care. Of the 116 supplements and herbs on file, 78 have sedative effects of their own, so the biggest theme by far is stacked drowsiness and slo…”

Reviewed by 2 · Jul 18, 2026

Open the Lamotrigine interaction page

One more smart check

Taking Copaiba Balsam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Copaiba Balsam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Copaiba Balsam. Even though Copaiba Balsam itself has no known interaction with Lamotrigine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Copaiba Balsam and Lamotrigine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Copaiba Balsam
Steady interest

#1,348 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lamotrigine
Top 5%

#36 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Copaiba Balsam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Copaiba Balsam and Lamotrigine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Copaiba Balsam

What is Copaiba Balsam?

  • Inflammation and joint pain
  • Skin wounds and irritation
  • Antimicrobial and antifungal support
  • Sore throat and respiratory comfort
  • Digestive complaints

Copaiba balsam is a resin from South American Copaifera trees, valued in traditional medicine and now popular as an essential oil and supplement, mainly for inflammation and skin concerns. Human evidence is limited, so its benefits are not well proven. Talk to a pharmacist or doctor before using it, and avoid undiluted oral use of the essential oil.

Copaifera officinalis · Fabaceae · Oleoresin (balsam) tapped from the trunk; essential oil distilled from the resin · Essential oil, oral softgels/capsules, topical creams and ointments, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Copaiba Balsam is a good idea for someone in your situation. Here is what our Copaiba Balsam record says about it on its own.

Copaiba Balsam: dosing

There is no well-established, standardized dose for copaiba balsam. The amount in products varies widely depending on whether it is a topical cream, an oral softgel, or a pure essential oil.The safest approach is to follow the directions on the product label and not exceed them. For topical use, dilute the essential oil in a carrier oil and patch test first. Avoid taking concentrated essential oil by mouth unless a knowledgeable healthcare professional directs you to.

From our Copaiba Balsam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Copaiba Balsam monograph & all interactions
Medication

About Lamotrigine

What Is Lamotrigine Used For?

Brand name: Lamictal

Lamotrigine is used to treat several types of seizures in adults and children aged 2 and older — including partial-onset seizures, generalized tonic-clonic (grand mal) seizures, and seizures related to Lennox-Gastaut syndrome. In older teens and adults, it can also be used alone (monotherapy) after transitioning off another seizure medicine.

For adults with bipolar I disorder, lamotrigine is used as a maintenance treatment — meaning it helps delay the return of mood episodes like depression, mania, or mixed states. It is not approved to treat an active manic or mixed episode that's happening right now.

See full Lamotrigine drug information
Keep checking

Other Drugs & Copaiba Balsam

Browse every other medication we’ve checked against Copaiba Balsam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Copaiba Balsam References

The 2 references that drive our Copaiba Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Copaiba Balsam and Lamotrigine Together: Common Questions

Is it safe to take Copaiba Balsam with Lamotrigine?
We do not list a known interaction between Copaiba Balsam and Lamotrigine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Copaiba Balsam and Lamotrigine have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Lamotrigine interact with any supplements?
Yes. Lamotrigine has documented interactions with 116 supplements in our database — Copaiba Balsam is not one of them. The Lamotrigine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lamotrigine and Copaiba Balsam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.