Queen's Delight Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Queen's Delight interacts with medications. The heart of this page is the interaction list — every drug Queen's Delight is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Queen's Delight is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Queen's Delight against your medication
Add one medicationDrugs that interact with Queen's Delight
0 medications have a known interaction with Queen's Delight, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Queen's Delight. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Queen's Delight combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Queen's Delight: Uses, Safety & Side Effects
Queen's Delight (Stillingia sylvatica) is a traditional North American herb once used as a 'blood purifier' and for skin and throat problems. There is very little modern scientific evidence to support these uses, and the plant contains irritating compounds that can cause significant side effects. Talk with a pharmacist or doctor before trying it.
- Scientific name
- Stillingia sylvatica
- Family
- Euphorbiaceae
- Part used
- Root and dried root (sometimes the root resin/oil)
- Common forms
- Dried root, tincture, fluid extract, capsules, and as part of traditional herbal blends
- Skin conditions and 'blood purifying'
- Chronic skin eruptions (eczema, psoriasis)
- Syphilis and other infections (historical use)
- Sore throat and respiratory complaints
- Constipation (as a laxative)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
It contains irritant compounds and has little modern safety data, so use cautiously and under professional guidance.
When the dried root preparations are used orally. ...when the dried or fresh root is used topically; avoid using.
Read the full pregnancy detailWhen the dried or fresh root are used topically.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Queen's Delight is a flowering plant native to the southeastern United States. Its botanical name is Stillingia sylvatica, and it belongs to the spurge family (Euphorbiaceae). The root is the part most often used in traditional herbal medicine.
Historically, Queen's Delight was popular among Native American groups and 19th-century herbalists, who used it as a so-called 'blood purifier' and for long-lasting skin problems, sore throats, and certain infections. It was sometimes combined with other herbs in old herbal formulas.
Today the herb is rarely used and is not a common supplement. It may still be found as a dried root, tincture, or fluid extract from specialty herbal suppliers.
How it works
Queen's Delight root contains a variety of plant compounds, including diterpene esters and a resin-like substance. Some of these diterpene compounds are known to irritate the skin and mucous membranes, which may explain its old reputation as a 'stimulating' or 'cleansing' herb.
Laboratory studies of plants in the spurge family suggest some of their compounds can affect cells and the immune system, but this research is early and does not prove the herb is helpful or safe in people. The exact way Queen's Delight might act in the body is not well understood.
It is important to know that much of this information comes from laboratory or animal research, or from traditional reports, rather than from carefully controlled human studies.
Does Queen's Delight work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Queen's Delight, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 5 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Bronchitis
Although there has been interest in using oral queen's delight for bronchitis, there is insufficient reliable information about the clinical effects of queen's delight for this condition.
Insufficient Reliable Evidence To Rate Constipation
Although there has been interest in using oral queen's delight for constipation, there is insufficient reliable information about the clinical effects of queen's delight for this condition.
Insufficient Reliable Evidence To Rate Gallbladder disease
Although there has been interest in using oral queen's delight for gallbladder disease, there is insufficient reliable information about the clinical effects of queen's delight for this condition.
Insufficient Reliable Evidence To Rate Hemorrhoids
Although there has been interest in using topical queen's delight for hemorrhoids, there is insufficient reliable information about the clinical effects of queen's delight for this condition.
Insufficient Reliable Evidence To Rate Laryngitis
Although there has been interest in using oral queen's delight for laryngitis, there is insufficient reliable information about the clinical effects of queen's delight for this condition.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Queen's Delight belongs to the spurge family, many members of which contain irritating and potentially toxic compounds. Fresh or strong preparations can irritate the mouth, throat, stomach, and skin.
Because there is little modern safety data, people with chronic health conditions, those taking other medicines, and older adults should be especially careful. Pregnant and breastfeeding women should avoid Queen's Delight because of its irritant nature and the lack of safety information. It should not be given to children.
Always speak with a pharmacist or doctor before using this herb, and stop using it if you notice any unusual or severe reactions.
Side effects
Reported and expected side effects relate mostly to the herb's irritating effect. These may include:
- Burning or irritation in the mouth and throat
- Nausea, stomach upset, or diarrhea
- Skin irritation with contact
Larger amounts may cause more intense gut irritation and stronger laxative effects. Because the plant family includes toxic species, taking too much could be harmful. If you have severe vomiting, severe diarrhea, trouble breathing, or signs of an allergic reaction, stop using it and seek medical care.
Queen's Delight: Reported Adverse Effects
Documented safety reports on Queen's Delight from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, queen's delight can cause vomiting, diarrhea, and nausea. In large amounts, it may cause a burning sensation of the mouth, throat, diarrhea, nausea, vomiting, dysuria, aches and pains, pruritus, skin eruptions, cough, depression, fatigue, and perspiration.
Topically, it may cause inflammation, swelling, and contact dermatitis.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established, standardized dose for Queen's Delight. Traditional herbalists used small amounts of the dried root, tincture, or fluid extract, but these doses were not tested in modern clinical studies.
If you choose to use a product, follow the directions on the label and do not exceed them. Because the herb can be irritating, starting low and using it only briefly is wise. Always check with a pharmacist or doctor first, especially if you take other medicines or have a health condition.
Queen's Delight & Pregnancy
Queen's Delight & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Queen's Delight monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Queen's Delight
5 brands in our database make a supplement containing Queen's Delight.
Supplement products with Queen's Delight
14 products in our database contain Queen's Delight. Open any to see its full ingredient list and every drug interaction we check.
Queen's Delight: Common Questions
What is Queen's Delight used for, and does it work?
Does Queen's Delight interact with prescription medications?
How are Queen's Delight interactions rated?
Is it safe to take Queen's Delight with my medications?
Where does this Queen's Delight interaction information come from?
What is Queen's Delight used for?
Is Queen's Delight safe to take?
Can I use Queen's Delight during pregnancy or while breastfeeding?
Does Queen's Delight really 'cleanse the blood'?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Queen's Delight
A rotating sample of real supplements in our database that list Queen's Delight — open any to see its full ingredients and every drug interaction we check.
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