Herb & supplement monograph

Queen's Delight Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Queen's Delight

0 medications have a known interaction with Queen's Delight, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Queen's Delight. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Queen's Delight combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Queen's Delight: Uses, Safety & Side Effects

The bottom line

Queen's Delight (Stillingia sylvatica) is a traditional North American herb once used as a 'blood purifier' and for skin and throat problems. There is very little modern scientific evidence to support these uses, and the plant contains irritating compounds that can cause significant side effects. Talk with a pharmacist or doctor before trying it.

Scientific name
Stillingia sylvatica
Family
Euphorbiaceae
Part used
Root and dried root (sometimes the root resin/oil)
Common forms
Dried root, tincture, fluid extract, capsules, and as part of traditional herbal blends
People commonly use it for
  • Skin conditions and 'blood purifying'
  • Chronic skin eruptions (eczema, psoriasis)
  • Syphilis and other infections (historical use)
  • Sore throat and respiratory complaints
  • Constipation (as a laxative)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

It contains irritant compounds and has little modern safety data, so use cautiously and under professional guidance.

PregnancyPossibly Unsafe

When the dried root preparations are used orally. ...when the dried or fresh root is used topically; avoid using.

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When the dried or fresh root are used topically.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Queen's Delight is a flowering plant native to the southeastern United States. Its botanical name is Stillingia sylvatica, and it belongs to the spurge family (Euphorbiaceae). The root is the part most often used in traditional herbal medicine.

Historically, Queen's Delight was popular among Native American groups and 19th-century herbalists, who used it as a so-called 'blood purifier' and for long-lasting skin problems, sore throats, and certain infections. It was sometimes combined with other herbs in old herbal formulas.

Today the herb is rarely used and is not a common supplement. It may still be found as a dried root, tincture, or fluid extract from specialty herbal suppliers.

How it works

Queen's Delight root contains a variety of plant compounds, including diterpene esters and a resin-like substance. Some of these diterpene compounds are known to irritate the skin and mucous membranes, which may explain its old reputation as a 'stimulating' or 'cleansing' herb.

Laboratory studies of plants in the spurge family suggest some of their compounds can affect cells and the immune system, but this research is early and does not prove the herb is helpful or safe in people. The exact way Queen's Delight might act in the body is not well understood.

It is important to know that much of this information comes from laboratory or animal research, or from traditional reports, rather than from carefully controlled human studies.

Effectiveness

Does Queen's Delight work?

Evidence overview · 5 uses evaluated
5 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Queen's Delight, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 5 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral queen's delight for bronchitis, there is insufficient reliable information about the clinical effects of queen's delight for this condition.

Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral queen's delight for constipation, there is insufficient reliable information about the clinical effects of queen's delight for this condition.

Insufficient Reliable Evidence To Rate Gallbladder disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral queen's delight for gallbladder disease, there is insufficient reliable information about the clinical effects of queen's delight for this condition.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical queen's delight for hemorrhoids, there is insufficient reliable information about the clinical effects of queen's delight for this condition.

Insufficient Reliable Evidence To Rate Laryngitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral queen's delight for laryngitis, there is insufficient reliable information about the clinical effects of queen's delight for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Queen's Delight belongs to the spurge family, many members of which contain irritating and potentially toxic compounds. Fresh or strong preparations can irritate the mouth, throat, stomach, and skin.

Because there is little modern safety data, people with chronic health conditions, those taking other medicines, and older adults should be especially careful. Pregnant and breastfeeding women should avoid Queen's Delight because of its irritant nature and the lack of safety information. It should not be given to children.

Always speak with a pharmacist or doctor before using this herb, and stop using it if you notice any unusual or severe reactions.

Side effects

Reported and expected side effects relate mostly to the herb's irritating effect. These may include:

  • Burning or irritation in the mouth and throat
  • Nausea, stomach upset, or diarrhea
  • Skin irritation with contact

Larger amounts may cause more intense gut irritation and stronger laxative effects. Because the plant family includes toxic species, taking too much could be harmful. If you have severe vomiting, severe diarrhea, trouble breathing, or signs of an allergic reaction, stop using it and seek medical care.

Queen's Delight: Reported Adverse Effects

Documented safety reports on Queen's Delight from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, queen's delight can cause vomiting, diarrhea, and nausea. In large amounts, it may cause a burning sensation of the mouth, throat, diarrhea, nausea, vomiting, dysuria, aches and pains, pruritus, skin eruptions, cough, depression, fatigue, and perspiration.

Topically, it may cause inflammation, swelling, and contact dermatitis.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established, standardized dose for Queen's Delight. Traditional herbalists used small amounts of the dried root, tincture, or fluid extract, but these doses were not tested in modern clinical studies.

If you choose to use a product, follow the directions on the label and do not exceed them. Because the herb can be irritating, starting low and using it only briefly is wise. Always check with a pharmacist or doctor first, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Queen's Delight & Pregnancy

Possibly Unsafe

When the dried root preparations are used orally. ...when the dried or fresh root is used topically; avoid using.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Likely Unsafe

When the fresh root preparations are used orally.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Queen's Delight & Breastfeeding

Possibly Unsafe

When the dried or fresh root are used topically.

Likely Unsafe

When used orally; contraindicated.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Queen's Delight monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Queen's Delight

5 brands in our database make a supplement containing Queen's Delight.

Product directory

Supplement products with Queen's Delight

14 products in our database contain Queen's Delight. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Queen's Delight: Common Questions

What is Queen's Delight used for, and does it work?
People use Queen's Delight for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Queen's Delight interact with prescription medications?
We do not currently list any known drug interactions for Queen's Delight. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Queen's Delight interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Queen's Delight with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Queen's Delight interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Queen's Delight used for?
Traditionally it was used as a 'blood purifier' and for chronic skin problems, sore throats, and certain infections. These are folk uses and are not backed by strong modern evidence.
Is Queen's Delight safe to take?
It is not well studied in people and contains irritating compounds, so it should be used cautiously and only under the guidance of a pharmacist or doctor. Avoid large or long-term use.
Can I use Queen's Delight during pregnancy or while breastfeeding?
No. It is best avoided during pregnancy and breastfeeding because there is no reliable safety information and the herb can be irritating.
Does Queen's Delight really 'cleanse the blood'?
There is no scientific proof that Queen's Delight cleanses the blood or detoxifies the body. This is a traditional concept, not a medically supported effect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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