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Dietary supplement

Lymphatic Drainage Drops for Bloat Relief & De-Puff Ingredients & Drug Interactions

by LYMPHORIA

Lymphatic Drainage Drops for Bloat Relief & De-Puff label
See full label image
Liquid Category: Herbal Supplement
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Jul 23, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking Lymphatic Drainage Drops for Bloat Relief & De-Puff against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lymphatic Drainage Drops for Bloat Relief & De-Puff is a dietary supplement by LYMPHORIA with 4 active ingredients. Its ingredients are commonly taken for menopause symptoms (hot flashes), high cholesterol, bone health/osteoporosis.Based on those ingredients, 883 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Clover Extract, Prickly Ash (Zanthoxylum americanum) bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA

Ask about any prescription or over-the-counter medication and we check it for interactions with Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.

This product contains 4 active ingredients: red clover extract, prickly ash (northern prickly ash) bark extract, stillingia (queen's delight) root extract, and cleavers. Red clover is a plant whose phytoestrogens give it hormone-like properties.

Prickly ash and stillingia are traditional herbal roots believed to support circulation and lymphatic function. Cleavers is a plant traditionally used in herbal drainage blends.

The inactive ingredients are vegetable glycerin and organic coconut water complex, which serve as the liquid base and carriers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: lymphatic drainage and fluid retention relief.
  • We looked for evidence on: lymphatic swelling, edema, bloating.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The data we hold does not establish how well this product works for bloat relief or de-puffing. Red clover has been studied for menopausal symptoms, osteoporosis, and hair loss, but our records show insufficient reliable evidence to rate it for any of those conditions.

There is no effectiveness data on file for prickly ash, stillingia, or cleavers for any condition.

The evidence, ingredient by ingredient Red Clover Northern Prickly Ash Queen's Delight Clivers

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Red clover is generally well tolerated short-term in healthy adults, but its hormone-like effects mean certain people need to be cautious—particularly those at risk for estrogen-sensitive cancers, since some research suggests it may increase breast density in younger women. The most common side effects reported are muscle pain, nausea, and vaginal spotting.

Prickly ash, stillingia, and cleavers have limited modern safety data; stillingia in particular contains irritant compounds and can cause vomiting, diarrhea, nausea, and skin reactions in larger amounts. For pregnancy: red clover safety data are sparse, so the safety data advise against it during pregnancy.

Prickly ash and stillingia are possibly unsafe in pregnancy, and cleavers lacks enough information to know either way—talk with your doctor or pharmacist for personalized advice. None of the ingredients have sufficient breastfeeding safety data, so they're best avoided while nursing.

Side effects, ingredient by ingredient Red Clover Northern Prickly Ash Queen's Delight Clivers

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Northern Prickly Ash, Red Clover.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 884 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any estrogen-containing medications (birth control, hormone therapy), tamoxifen, methotrexate, H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (like omeprazole or lansoprazole). Also mention any medications metabolized by CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes, and blood thinners—red clover has theoretical interactions with these, though clinical evidence is mixed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is not well-studied for its stated purpose, and its herbal ingredients carry interactions and safety concerns that warrant a conversation with your doctor or pharmacist before you start—especially if you take hormone-related medications, methotrexate, tamoxifen, or acid-reducing drugs. The short-term safety profile of red clover is reasonable in healthy adults not pregnant or nursing, but the other ingredients have minimal modern safety research.

If you're considering this for bloat or puffiness, ask your healthcare provider whether the ingredients and interactions make sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lymphatic Drainage Drops for Bloat Relief & De-Puff, straight from the product label.

Brand LYMPHORIA
Barcode (UPC) 199874312149
Net contents 2 Fl Oz (59 mL) per bottle, Pack of 2
Market status On market
Added to our catalog Jul 23, 2026
Product type Herbal Supplement
Supplement form Liquid
Dietary claims / uses Lymphatic drainage support, Bloat relief, De-puffing / reduces swelling, Fluid retention / fluid balance, Natural detoxification support, Healthy circulation support
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
59
UPC/BARCODE
199874312149
IngredientAmount% DV
Red Clover Extract----
Prickly Ash (Zanthoxylum americanum) bark extract----
Stillingia root extract----
Cleavers----

Other ingredients: Vegetable Glycerin, organic Coconut Water Complex

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

Squeeze 1–2 droppers (1–2 mL) once daily. Add to water, tea, juice — or under the tongue. Best results with consistent daily use.

Warnings

Do not use if bottle seal is missing.

Storage

Store in a cool, dry place.

Marketing

TRADITIONAL LYMPHATIC SUPPORT

Supports Drainage · Boosts Clarity · Reduces Swelling · Balances Fluids

Lymphatic drainage drops for bloat relief & de-puff — lymph node detox cleanse, fluid retention

Formulated to help your body release trapped fluid and restore natural lymph flow

Seamless daily lymphatic system support and immune health maintenance

Formulated specifically for women's wellness

Other

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Distributed by: Lymphoria, a division of Looxe LLC, 8255 NW 66TH STREET, MIAMI, FL 33166

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

Lymphatic Drainage Drops for Bloat Relief & De-Puff label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container59 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Red Clover Extract

Interacts with
867 drugs
Form: Flower extract

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot f...

Red Clover Extract monograph & interactions

Prickly Ash (Zanthoxylum americanum) bark extract

Interacts with
36 drugs
Form: Bark extract

Northern Prickly Ash is a North American shrub whose bark and berries have a long history in folk medicine, especially for toothache, joint pain, and...

Prickly Ash (Zanthoxylum americanum) bark extract monograph & interactions

Stillingia root extract

No known
interactions
Form: Root extract

Queen's Delight (Stillingia sylvatica) is a traditional North American herb once used as a 'blood purifier' and for skin and throat problems. There is...

Stillingia root extract monograph & interactions

Cleavers

No known
interactions
Form: Aerial parts extract

Clivers (Galium aparine) is a common wild plant used in traditional herbal medicine mainly as a 'cleansing' herb, mild diuretic, and skin remedy. Stro...

Cleavers monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Organic Coconut Water Complex. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA Drug Interactions

Want to check YOUR meds against Lymphatic Drainage Drops for Bloat Relief & De-Puff?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
883Drugs
44 Moderate 839 Minor

Ingredients driving the most interactions

Red Clover Extract 867
Prickly Ash (Zanthoxylum americanum) bark extract 36

Individual Drug Interactions

The ingredients in Lymphatic Drainage Drops for Bloat Relief & De-Puff interact with 883 drugs. Click any drug to see the details.

2 of the 4 ingredients in Lymphatic Drainage Drops for Bloat Relief & De-Puff interact with drugs. Each result below shows which ingredient is responsible. Red Clover Extract Prickly Ash (Zanthoxylum americanum) bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lymphatic Drainage Drops for Bloat Relief & De-Puff with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Clover Extract9 drug types · 867 drugs

Estrogens

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.

Likelihood Probable Evidence D
Methotrexate (Trexall, Others)

Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.

Likelihood Unlikely Evidence B
Caffeine

Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.

Likelihood Unlikely Evidence B
Red Clover Extract full monograph & interactions

Prickly Ash (Zanthoxylum americanum) bark extract3 drug types · 36 drugs

Antacids

Theoretically, northern prickly ash might decrease the effectiveness of antacids.
There are reports that northern prickly ash increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, northern prickly ash might decrease the effectiveness of H2-blockers.
There are reports that northern prickly ash increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, northern prickly ash might decrease the effectiveness of PPIs.
There are reports that northern prickly ash increases stomach acid.

Likelihood Possible Evidence D
Prickly Ash (Zanthoxylum americanum) bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lymphatic Drainage Drops for Bloat Relief & De-Puff, from the product label.

LYMPHORIA

See all LYMPHORIA products
Pharmacist Counseling Corner

Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA: Common Questions

Does Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA interact with any medications?
Yes. Based on its ingredients, Lymphatic Drainage Drops for Bloat Relief & De-Puff has a known interaction with 883 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lymphatic Drainage Drops for Bloat Relief & De-Puff contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Red clover, prickly ash, and stillingia all lack sufficient safety data or are considered possibly unsafe in pregnancy, and none have reliable safety information for breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you at this time.
What side effects might I experience?
Red clover's most common side effects are muscle pain, nausea, and vaginal spotting. Stillingia (queen's delight) can cause vomiting, diarrhea, nausea, and skin reactions, especially in larger amounts. The other ingredients have limited reported side effects in the data we hold.
Does this actually work for bloat and puffiness?
The evidence isn't established in the data we hold. While these are traditional herbal ingredients, there's no clinical evidence on file showing this combination—or even the individual ingredients—reduces bloat or puffiness.
Is this safe if I'm taking birth control or hormone therapy?
Not without checking first. Red clover contains phytoestrogens that may interfere with estrogen-based medications. Talk with your doctor or pharmacist before combining this product with any hormone-related medication.
What if I take a medication for acid reflux?
Prickly ash may theoretically reduce how well H2-blockers, antacids, and proton pump inhibitors work, because it's reported to increase stomach acid. Check with your doctor or pharmacist before starting this product if you take any of those medications.
Are there any fillers or extra ingredients I should know about?
The inactive ingredients are vegetable glycerin and organic coconut water complex, which are the liquid base and carriers for the active herbal extracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lymphatic Drainage Drops for Bloat Relief & De-Puff label
Go deeper

The Full Monographs Behind Lymphatic Drainage Drops for Bloat Relief & De-Puff’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Red Clover

Interacts with 867 drugs

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and genera...

Read the full Red Clover monograph → Herb & supplement monograph

Northern Prickly Ash

Interacts with 36 drugs

Northern Prickly Ash is a North American shrub whose bark and berries have a long history in folk medicine, especially for toothache, joint pain, and sluggish digestion. Modern scientific ev...

Read the full Northern Prickly Ash monograph → Herb & supplement monograph

Queen's Delight

Queen's Delight (Stillingia sylvatica) is a traditional North American herb once used as a 'blood purifier' and for skin and throat problems. There is very little modern scientific evidence...

Read the full Queen's Delight monograph → Herb & supplement monograph

Clivers

Clivers (Galium aparine) is a common wild plant used in traditional herbal medicine mainly as a 'cleansing' herb, mild diuretic, and skin remedy. Strong human evidence for these uses is lack...

Read the full Clivers monograph →
Sources

Sources & How We Checked

Lymphatic Drainage Drops for Bloat Relief & De-Puff's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Red Clover 24 references
  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
  16. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
  17. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
  18. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  19. Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
  20. Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
  21. Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
  22. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
  23. Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
  24. Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed

See these in context on the Red Clover monograph →

Northern Prickly Ash 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Northern Prickly Ash monograph →

Queen's Delight 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Queen's Delight monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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