Herb & supplement monograph

Clivers Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Clivers

0 medications have a known interaction with Clivers, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Clivers. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Clivers combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Clivers: Uses, Safety & Side Effects

The bottom line

Clivers (Galium aparine) is a common wild plant used in traditional herbal medicine mainly as a 'cleansing' herb, mild diuretic, and skin remedy. Strong human evidence for these uses is lacking, so its benefits remain unproven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding because safety is not established.

Scientific name
Galium aparine
Family
Rubiaceae
Part used
Aerial parts (the leaves, stems, and flowering tops gathered above ground)
Common forms
Tea (infusion), tincture, fresh juice, capsules, and topical preparations
People commonly use it for
  • Supporting urinary tract and 'cleansing'
  • Mild swelling or fluid retention (diuretic use)
  • Skin conditions like eczema and psoriasis
  • Swollen lymph glands
  • Minor wounds and skin irritation (topical)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally considered low-risk in food-like amounts, but human safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Clivers, also spelled cleavers, is a sprawling wild plant known to scientists as Galium aparine. It belongs to the same plant family as coffee and grows widely across Europe, Asia, and North America in hedgerows, gardens, and waste ground. Its stems and tiny hooked hairs cling to clothing and other plants, which is why it is sometimes called 'sticky weed' or 'goosegrass.'

The above-ground parts of the plant have been used for centuries in folk and herbal medicine. People traditionally take it as a tea, a fresh juice, or a tincture. It is best known as a so-called 'cleansing' or 'spring tonic' herb, and is also used in skin remedies and as a mild diuretic (a substance that increases urine flow).

How it works

Clivers contains a mix of plant compounds, including iridoid glycosides (such as asperuloside), flavonoids, tannins, and other antioxidants. These are thought to give it mild anti-inflammatory and antioxidant effects, but most of this comes from laboratory studies rather than human trials.

Its traditional reputation as a diuretic and 'cleansing' herb is the proposed reason people use it for urinary and skin complaints. However, these mechanisms are not well proven in people, and the actual amounts of active compounds in a cup of tea or a supplement can vary a lot.

Effectiveness

Does Clivers work?

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Clivers, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Pressure ulcers
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical clivers for pressure ulcers, there is insufficient reliable information about the clinical effects of clivers for this purpose.

Insufficient Reliable Evidence To Rate Psoriasis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral clivers for psoriasis, there is insufficient reliable information about the clinical effects of clivers for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Clivers has a long history of use and is generally thought to be low-risk when used in small, food-like amounts. Still, formal safety studies in humans are very limited, so its long-term safety is not well understood.

Because it may act as a mild diuretic, people with kidney problems, diabetes, or low blood pressure should be cautious and check with a healthcare provider first. People who are allergic to plants in the bedstraw or madder (Rubiaceae) family should avoid it.

Pregnancy and breastfeeding: There is not enough reliable information to know whether clivers is safe during pregnancy or while breastfeeding. To be safe, avoid it during these times. Always talk with a pharmacist or doctor before trying clivers, especially if you take medicines or have a medical condition.

Side effects

Reported side effects are uncommon and usually mild. Some people may notice an upset stomach, and skin contact with the fresh plant can occasionally cause irritation or an allergic skin reaction in sensitive people.

Because clivers may increase urine output, drinking large amounts could in theory affect your fluid balance. Stop using it and seek medical care if you notice signs of an allergic reaction, such as rash, swelling, or trouble breathing.

Dosing

There is no official, well-studied standardized dose for clivers. Traditional use varies widely depending on whether it is taken as a tea, tincture, or fresh juice, and product strengths differ from brand to brand.

The safest approach is to follow the directions on the product label and not exceed the suggested amount. Because reliable dosing information is lacking, check with a pharmacist or doctor before starting clivers, particularly if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Clivers & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Clivers & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Clivers

5 brands in our database make a supplement containing Clivers.

Product directory

Supplement products with Clivers

17 products in our database contain Clivers. Open any to see its full ingredient list and every drug interaction we check.

Bedstraw by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bedstraw Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bedstraw Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bedstraw Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bedstraw Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Kidney Blend SP-6 by Solaray Capsule 100 VegCap(s) View ingredients & interactions Kidney Blend SP-6 by Solaray Capsule 100 VegCap(s) View ingredients & interactions Kidney Blend SP-6 by Solaray Capsule 100 VegCap(s) View ingredients & interactions Kidney Blend SP-6 by Solaray Capsule 100 VegCap(s) View ingredients & interactions Kidney Formula by Vita Logic Capsule 180 VegCap(s) View ingredients & interactions Kidney Formula by Vita Logic Capsule 90 VegCap(s) View ingredients & interactions Lymphatic Drainage Drops for Bloat Relief & De-Puff by LYMPHORIA Liquid 2 Fl Oz (59 mL) per bottle, Pack of 2 View ingredients & interactions Total Cleanse Lymph by Solaray Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Total Cleanse Lymph by Solaray Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Total Cleanse Lymph by Solaray Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Kidney Blend SP-6 by Solaray Capsule 100 VegCap(s) Off market View ingredients & interactions Red Clover Supreme by Gaia Herbs Liquid 1 fl. Oz. · 30 mL Off market View ingredients & interactions
Pharmacist Counseling Corner

Clivers: Common Questions

What is Clivers used for, and does it work?
People use Clivers for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Clivers interact with prescription medications?
We do not currently list any known drug interactions for Clivers. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Clivers interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Clivers with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Clivers interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Clivers used for?
It is traditionally used as a 'cleansing' herb, a mild diuretic, and for skin conditions and swollen lymph glands. These uses come mostly from tradition, and strong scientific proof that it works is lacking.
Is Clivers safe to take?
In small, food-like amounts it is generally considered low-risk, but human safety studies are limited. Talk to your pharmacist or doctor before using it, especially if you have kidney problems or take other medicines.
Can I use Clivers during pregnancy or breastfeeding?
It is best to avoid it. There is not enough reliable safety information for use during pregnancy or breastfeeding, so the cautious choice is to skip it.
How is Clivers usually taken?
It is most often taken as a tea or tincture made from the above-ground parts of the plant, and is sometimes used as a fresh juice or applied to the skin. Follow the product label for amounts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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