Herb & supplement monograph

Ylang Ylang Oil Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Ylang Ylang Oil

0 medications have a known interaction with Ylang Ylang Oil, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Ylang Ylang Oil. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Ylang Ylang Oil combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Ylang Ylang Oil: Uses, Safety & Side Effects

The bottom line

Ylang ylang oil is a fragrant essential oil made from the flowers of the Cananga odorata tree, used mostly in aromatherapy and skin care for relaxation. Some small studies hint at mild calming effects, but the evidence is limited, and it should never be swallowed and must always be diluted before being applied to skin.

Scientific name
Cananga odorata
Family
Annonaceae
Part used
Essential oil distilled from the flowers
Common forms
Essential oil, diluted massage oil, aromatherapy blends, room diffusers, perfumes and cosmetics
People commonly use it for
  • Stress and anxiety relief
  • Aromatherapy and relaxation
  • Promoting restful sleep
  • Skin and hair care
  • Mood and well-being

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe for aromatherapy or diluted topical use, but it can cause skin irritation and should not be taken by mouth.

PregnancyLikely Safe

When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient re...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient re...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Ylang ylang oil is an essential oil made by steam-distilling the bright yellow flowers of the Cananga odorata tree. This tropical tree grows in parts of Southeast Asia, including Indonesia and the Philippines, and on islands such as Madagascar and the Comoros.

The oil has a sweet, floral scent and is a popular ingredient in perfumes, soaps, lotions, and aromatherapy blends. People most often use it as a fragrance and for relaxation, either by breathing in the scent from a diffuser or by applying it to the skin after diluting it in a carrier oil.

How it works

Ylang ylang oil contains aromatic compounds such as linalool, benzyl acetate, benzyl benzoate, germacrene, and caryophyllene. These give the oil its scent and are thought to be responsible for its effects.

Researchers believe the pleasant aroma may influence the nervous system through smell, possibly promoting a sense of calm and lowering markers of stress. Laboratory studies have also looked at possible antimicrobial and antioxidant activity. It is important to know that much of this work is based on lab or animal research, and these findings do not prove the oil works the same way in people.

Effectiveness

Does Ylang Ylang Oil work?

Evidence overview · 6 uses evaluated
6 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Ylang Ylang Oil, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 6 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

It is unclear if ylang ylang oil aromatherapy reduces anxiety.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if ylang ylang oil aromatherapy is beneficial in improving cognitive function.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Ylang ylang oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Labor pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if ylang ylang oil aromatherapy is beneficial for labor pain.

Insufficient Reliable Evidence To Rate Lice
Rating & evidence shown verbatim from Natural Medicines

Topical ylang ylang oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Suicidal ideation
Rating & evidence shown verbatim from Natural Medicines

It is unclear if ylang ylang oil aromatherapy is beneficial in patients with suicidal ideation.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Ylang ylang oil is generally considered safe for aromatherapy and for diluted use on the skin in most healthy adults. Like all essential oils, it is very concentrated and must be diluted in a carrier oil (such as coconut or jojoba oil) before being applied to skin.

Do not swallow ylang ylang oil. Essential oils can be toxic if taken by mouth. Keep it out of the reach of children and pets, and avoid getting it in the eyes.

People with sensitive skin, eczema, or fragrance allergies should be cautious and do a small patch test first. For pregnancy and breastfeeding, there is not enough safety information, so it is best to avoid concentrated use and limit yourself to occasional, well-ventilated aromatherapy only if your doctor agrees. When in doubt, check with your pharmacist or doctor.

Side effects

The most common side effects are skin reactions, including redness, irritation, or allergic contact dermatitis, especially when the oil is used undiluted. Some people may also find the strong scent causes headache or nausea, particularly in poorly ventilated spaces.

Rarely, sensitive individuals may develop a more significant allergic reaction. If you notice a rash, swelling, trouble breathing, or other signs of an allergic reaction, stop using it and seek medical care. Swallowing essential oils can cause serious poisoning and is a medical emergency.

Ylang Ylang Oil: Reported Adverse Effects

Documented safety reports on Ylang Ylang Oil from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is currently a limited amount of information on the adverse effects of ylang ylang oil. A thorough evaluation of safety outcomes has not been conducted.

Most Common Adverse Effects:

Topically: Dermatitis, pruritus.

Reports by condition
Dermatitis Immunologic

Topically, ylang ylang oil in combination with other herbs has caused contact dermatitis in various case reports.

  1. Posadzki P, Alotaibi A, Ernst E. Adverse effects of aromatherapy: a systematic review of case reports and case series. Int J Risk Saf Med. 2012;24(3):147-61.
Pruritus Dermatologic

Topically, ylang ylang oil in combination with other herbs can cause localized pruritus.

  1. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for ylang ylang oil, and it is not meant to be taken internally. For aromatherapy, a few drops are typically added to a diffuser or inhaled briefly. For topical use, the oil should always be diluted to a low concentration in a carrier oil.

Because products vary widely in strength, follow the directions on the label and start with the smallest amount. If you are unsure how to use it safely, ask your pharmacist or a qualified aromatherapist.

Pregnancy & Breastfeeding

Ylang Ylang Oil & Pregnancy

Likely Safe

When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of using ylang ylang oil in medicinal amounts. Additionally, there is insufficient reliable information available regarding use of ylang ylang oil as aromatherapy during labor. Ylang ylang oil aromatherapy has been used with apparent safety during active labor in a small clinical study. However, a high-quality assessment of safety has not been conducted.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Sirkeci I, Cagan O, Koc S. The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women: A randomized controlled trial. Complement Ther Clin Pract. 2023; 52:101748.

Ylang Ylang Oil & Breastfeeding

Likely Safe

When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of using ylang ylang oil in medicinal amounts. Additionally, there is insufficient reliable information available regarding use of ylang ylang oil as aromatherapy during labor. Ylang ylang oil aromatherapy has been used with apparent safety during active labor in a small clinical study. However, a high-quality assessment of safety has not been conducted.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Sirkeci I, Cagan O, Koc S. The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women: A randomized controlled trial. Complement Ther Clin Pract. 2023; 52:101748.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Ylang Ylang Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
  3. Posadzki P, Alotaibi A, Ernst E. Adverse effects of aromatherapy: a systematic review of case reports and case series. Int J Risk Saf Med. 2012;24(3):147-61. PubMed
  4. Sirkeci I, Cagan O, Koc S. The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women: A randomized controlled trial. Complement Ther Clin Pract. 2023; 52:101748. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Ylang Ylang Oil: Common Questions

What is Ylang Ylang Oil used for, and does it work?
People use Ylang Ylang Oil for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Ylang Ylang Oil interact with prescription medications?
We do not currently list any known drug interactions for Ylang Ylang Oil. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Ylang Ylang Oil interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Ylang Ylang Oil with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Ylang Ylang Oil interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Ylang Ylang Oil used for?
It is used mainly in aromatherapy and skin and hair care for relaxation, stress relief, and its sweet floral fragrance. Evidence for medical benefits is limited.
Can I take Ylang Ylang Oil by mouth?
No. Like other essential oils, ylang ylang should not be swallowed because it can be toxic. It is meant for inhalation or diluted use on the skin only.
Is Ylang Ylang Oil safe during pregnancy?
Its safety in pregnancy has not been well studied, so it is best to avoid concentrated use and check with your doctor before using it even for aromatherapy.
Do I need to dilute Ylang Ylang Oil before putting it on my skin?
Yes. Always dilute it in a carrier oil and do a small patch test first, since undiluted essential oil can cause skin irritation or allergic reactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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