Drug & supplement interaction

Calcium + Lamotrigine

Lamotrigine brand name: Lamictal.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Calcium and Lamotrigine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Calcium and Lamotrigine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lamotrigine and Calcium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calcium safety at a glance

Calcium overall Generally safe Generally safe when taken at recommended amounts, but high doses can cause problems.
Pregnancy Likely Safe When used orally and appropriately. The World Health Organization (WHO) recommends prescribing oral calcium supplementation 1.5-2 grams daily during pregnancy t... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately. The World Health Organization (WHO) recommends prescribing oral calcium supplementation 1.5-2 grams daily during pregnancy t... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lamotrigine and Calcium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lamotrigine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lamotrigine is filed under 5 classifications — including anticonvulsants, glucuronidated drugs, cns depressants. Calcium has documented interactions with 18 drug classes — the most serious being ceftriaxone (rocephin) (major), dolutegravir (tivicay) (major) and elvitegravir (vitekta) (major) — and none of Lamotrigine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calcium Does Interact With Other Medications

Calcium has 7 major, 143 moderate, 18 minor known drug interactions in our database — Lamotrigine isn’t one of them. If you take anything else, check it against the full list below.

Major 7 Moderate 143 Minor 18 No known interaction 2,662 (incl. Lamotrigine)
Taking anything else?

Check Another of Your Medications Against Calcium

Covers the 2,830 medications we’ve checked against Calcium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Calcium and Lamotrigine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Calcium

    “There has been concern that calcium intake may be associated with an increased risk of cardiovascular disease (CVD) and coronary heart disease (CHD), including myocardial infarction (MI). Some clinical research suggests that calcium intake, often in amounts over the recommended daily intake level of 1000-1300 mg daily for adults, is associated with an increased risk of CVD, CHD, and MI.”

    Calcium · Natural Medicines adverse-effect record, reported in cardiovascular disease (cvd).

    6 sources cited
    1. 16118. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
    2. 17482. Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691. PubMed
    3. 91350. Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation i
    4. 107233. Myung SK, Kim HB, Lee YJ, Choi YJ, Oh SW. Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials. Nutrients 2021;13(2):368. PubMed
    5. 94137. Grove ML, Cook D. Calcium and heart attacks. Doesn't apply to most calcium prescriptions. BMJ. 2010;341:c5003. PubMed
    6. 92994. Chung M, Tang AM, Fu Z. Calcium Intake and Cardiovascular Disease Risk: An Updated Systematic Review and Meta-analysis. Ann Intern Med. 2016 Oct 25. PubMed

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

  • Stomach upset / Constipation / Diarrhea Additional detail

    Calcium

    “Orally, calcium can cause belching, flatulence, nausea, gastrointestinal discomfort, and diarrhea. Although constipation is frequently cited as an adverse effect of calcium, there is no scientific substantiation of this side effect. Calcium carbonate has been reported to cause acid rebound, but this is controversial.”

    Calcium · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 1824. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
    2. 1843. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
    3. 12950. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
    4. 38803. Dickinson, H. O., Nicolson, D. J., Cook, J. V., Campbell, F., Beyer, F. R., Ford, G. A., and Mason, J. Calcium supplementation for the management of primary hypertension in adults. Cochrane.Database.Syst.Rev. 2006;(2):CD004639. PubMed
    5. 1844. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
    6. 1845. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

  • Nausea Additional detail

    Calcium

    Recorded for Calcium in the same Natural Medicines adverse-effect record shown under Stomach upset / Constipation / Diarrhea above.

    Lamotrigine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lamotrigine. Read the label on DailyMed ›

Reported for Calcium but not commonly for Lamotrigine: a heart attack, kidney problems, a severe skin reaction and kidney stones.

Effects for Lamotrigine come from the ADVERSE REACTIONS section of its FDA label; effects for Calcium come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Calcium in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. The World Health Organization (WHO) recommends prescribing oral calcium supplementation 1.5-2 grams daily during pregnancy to those with low dietary calcium intake to prevent pre-eclampsia.

Pregnancy And Lactation Possibly Unsafe

When used orally in excessive doses. The Institute of Medicine sets the same daily tolerable upper intake level (UL) for calcium according to age independent of pregnancy status: 9-18 years, 3000 mg; 19-50 years, 2500 mg. Doses over these amounts might increase the risk of neonatal hypocalcemia-induced seizures possibly caused by transient neonatal hypoparathyroidism in the setting of excessive calcium supplementation during pregnancy, especially during the third trimester. Neonatal hypocalcemia is a risk factor for neonatal seizures.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Calcium or Lamotrigine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calcium or Lamotrigine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lamotrigine

This page covers Calcium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lamotrigine page lists 116 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 92 moderate · 17 minor.

From our pharmacist’s overview on the Lamotrigine page

“Alcohol, ordinary beer or wine, sits at the top of the interaction list for lamotrigine (Lamictal), with well-documented added sedation, and it sets the tone for a list I would treat with real care. Of the 116 supplements and herbs on file, 78 have sedative effects of their own, so the biggest theme by far is stacked drowsiness and slo…”

Reviewed by 2 · Jul 18, 2026

Open the Lamotrigine interaction page

One more smart check

Taking Calcium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38,397 real supplement products containing Calcium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calcium. Even though Calcium itself has no known interaction with Lamotrigine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calcium and Lamotrigine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calcium
Top 10

#2 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lamotrigine
Top 5%

#32 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calcium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Calcium and Lamotrigine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calcium

What is Calcium?

  • Bone health and osteoporosis prevention
  • Dietary calcium deficiency
  • Heartburn relief (calcium carbonate antacids)
  • Supporting healthy teeth
  • High blood pressure support during pregnancy

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting calcium from food, and supplements should be used at the lowest dose needed. Talk to your pharmacist or doctor before starting, especially if you have kidney problems or take other medicines.

Mineral (not a plant part) · Tablets, capsules, chewable tablets, liquids, powders; common salts include calcium carbonate and calcium citrate

An interaction check asks whether these two react with each other — it does not ask whether Calcium is a good idea for someone in your situation. Here is what our Calcium record says about it on its own.

Calcium: dosing

The right amount of calcium depends on your age, sex, diet, and health needs. Recommended daily amounts are set by health authorities and generally increase with age, especially for older women. There are also upper limits that should not be exceeded without medical advice. Because needs vary, this monograph does not list specific milligram amounts.A few practical tips: your body absorbs calcium best when you take no more than about 500 to 600 mg at one time, so larger daily amounts are usually split into separate doses. Calcium carbonate should be taken with food, while calcium citrate can be taken with or without food.

From our Calcium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calcium monograph & all interactions
Medication

About Lamotrigine

What Is Lamotrigine Used For?

Brand name: Lamictal

Lamotrigine is used to treat several types of seizures in adults and children aged 2 and older — including partial-onset seizures, generalized tonic-clonic (grand mal) seizures, and seizures related to Lennox-Gastaut syndrome. In older teens and adults, it can also be used alone (monotherapy) after transitioning off another seizure medicine.

For adults with bipolar I disorder, lamotrigine is used as a maintenance treatment — meaning it helps delay the return of mood episodes like depression, mania, or mixed states. It is not approved to treat an active manic or mixed episode that's happening right now.

See full Lamotrigine drug information
Keep checking

Other Drugs & Calcium

Browse every other medication we’ve checked against Calcium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

7Major
143Moderate
18Minor
2,661No known interaction
7 Major 143 Moderate 18 Minor 2,661 No interaction
Major

7 interactions

Moderate

143 interactions

Showing 60 of 143 moderate interactions — see all 143 on the Calcium page.

Minor

18 interactions

No interaction 2,661 drugs checked — show the list

We also checked Calcium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,661 medications checked with no known interaction — see the full Calcium list.

See the full Calcium interactions page
See every supplement checked against Lamotrigine, ranked by severity
Evidence & sources

Calcium References

The 62 references that drive our Calcium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calcium and Lamotrigine Together: Common Questions

Is it safe to take Calcium with Lamotrigine?
We do not list a known interaction between Calcium and Lamotrigine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Calcium and Lamotrigine have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Calcium and Lamotrigine combination checked?
Interactions in our licensed database are recorded against drug classes. Lamotrigine is filed under 5 classifications, and Calcium has documented interactions with 18 drug classes — none of Lamotrigine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calcium interact with any other medications?
Yes. Calcium has 168 documented drug interactions in our database — Lamotrigine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lamotrigine interact with any supplements?
Yes. Lamotrigine has documented interactions with 116 supplements in our database — Calcium is not one of them. The Lamotrigine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calcium monograph Uses, safety profile, and every drug interaction in one place Lamotrigine drug information The full plain-English guide to this medication Lamotrigine supplement interactions Every supplement checked against Lamotrigine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 62 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lamotrigine and Calcium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.