Drug & supplement interaction

Calcium + Lercanidipine hydrochloride

Lercanidipine hydrochloride brand name: Zanidip.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Calcium has a minor interaction with Lercanidipine hydrochloride. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Calcium and Lercanidipine hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Minor

CALCIUM CHANNEL BLOCKERS

Why this applies to Lercanidipine hydrochloride

Lercanidipine hydrochloride falls under CALCIUM CHANNEL BLOCKERS — the group Calcium interacts with.

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Good news here: this is mostly a non-issue for your daily calcium pill. Lercanidipine works by relaxing your blood vessels to lower blood pressure, and in theory, calcium given into a vein in a hospital can push back against that effect. That's actually how doctors treat a calcium channel blocker overdose. But the calcium tablet you take at home doesn't reach your blood the same way, so it's very unlikely to weaken your lercanidipine or cause your blood pressure to creep back up.

The evidence behind this is theoretical, not something seen in real patients taking oral calcium. So I wouldn't lose sleep over it. If you ever notice your blood pressure readings climbing or feel off, just check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  2. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  3. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Calcium Also Interacts With Other Medications

Calcium has 7 major, 143 moderate, 17 minor known drug interactions in our database — the Lercanidipine hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Major 7 Moderate 143 Minor 17 No known interaction 2,663 (incl. Lercanidipine hydrochloride)
Taking anything else?

Check Another of Your Medications Against Calcium

Covers the 2,830 medications we’ve checked against Calcium. Pick one to open its full report.

From our Q&A

Questions About Calcium or Lercanidipine hydrochloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calcium or Lercanidipine hydrochloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lercanidipine hydrochloride

This page covers Calcium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lercanidipine hydrochloride page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 7 major · 183 moderate · 42 minor.

From our pharmacist’s overview on the Lercanidipine hydrochloride page

“Lercanidipine (Zanidip) is a calcium channel blocker for high blood pressure, and its supplement list deserves genuine care. 232 interacting ingredients are on file, seven rated major, and most either change how much drug reaches your blood or shift blood pressure directly.”

Reviewed by 2 · Jul 18, 2026

Open the Lercanidipine hydrochloride interaction page

One more smart check

Taking Calcium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38,397 real supplement products containing Calcium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calcium. Your product may carry other ingredients that interact with Lercanidipine hydrochloride too, on top of Calcium — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calcium and Lercanidipine hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calcium
Top 10

#2 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lercanidipine hydrochloride
Steady interest

#1,555 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Calcium

What is Calcium?

  • Bone health and osteoporosis prevention
  • Dietary calcium deficiency
  • Heartburn relief (calcium carbonate antacids)
  • Supporting healthy teeth
  • High blood pressure support during pregnancy

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting calcium from food, and supplements should be used at the lowest dose needed. Talk to your pharmacist or doctor before starting, especially if you have kidney problems or take other medicines.

Read the full Calcium monograph & all interactions
Keep checking

Other Drugs & Calcium

Browse every other medication we’ve checked against Calcium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

7Major
143Moderate
17Minor
2,662No known interaction
7 Major 143 Moderate 17 Minor 2,662 No interaction
Major

7 interactions

Moderate

143 interactions

Showing 60 of 143 moderate interactions — see all 143 on the Calcium page.

Minor

17 interactions

No interaction 2,662 drugs checked — show the list

We also checked Calcium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,662 medications checked with no known interaction — see the full Calcium list.

See the full Calcium interactions page
See every supplement checked against Lercanidipine hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Calcium monograph › Uses, safety, and every drug interaction in one place Lercanidipine hydrochloride supplement interactions › Every supplement checked against Lercanidipine hydrochloride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Calcium and Lercanidipine hydrochloride Together: Common Questions

Can you take Calcium with Lercanidipine hydrochloride?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Calcium and Lercanidipine hydrochloride interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lercanidipine hydrochloride and Calcium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.