Hemlock Water Dropwort Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Hemlock Water Dropwort interacts with medications. The heart of this page is the interaction list — every drug Hemlock Water Dropwort is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Hemlock Water Dropwort is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Hemlock Water Dropwort against your medication
Add one medicationDrugs that interact with Hemlock Water Dropwort
0 medications have a known interaction with Hemlock Water Dropwort, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Hemlock Water Dropwort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Hemlock Water Dropwort combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Hemlock Water Dropwort: Uses, Safety & Side Effects
Hemlock water dropwort is one of the most poisonous plants in Europe and is NOT a safe dietary supplement or herbal remedy. Every part of the plant is toxic, and even small amounts can cause seizures, heart problems, and death. Do not consume it in any form.
- Scientific name
- Oenanthe crocata
- Family
- Apiaceae
- Part used
- Whole plant, especially the roots (highly toxic)
- Common forms
- Not used as a supplement; the plant is a poisonous wild herb
- Historical/folk wound poultices (unsafe)
- Traditional topical use (unsafe)
- Subject of toxicology research
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
This plant is highly poisonous and can be fatal if eaten.
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Hemlock water dropwort (Oenanthe crocata) is a wild flowering plant in the carrot and parsley family (Apiaceae). It grows in wet places such as ditches, riverbanks, marshes, and damp meadows, mainly in Britain, Ireland, and parts of western Europe.
The plant has clusters of small white flowers and finely divided leaves, and its thick roots are sometimes mistaken for edible plants like wild parsnip or water parsley. This mistake has caused many serious and even fatal poisonings.
Unlike most herbs covered on this site, hemlock water dropwort is not sold or used as a dietary supplement. It is included here mainly as a safety warning because it is one of the deadliest plants in Europe.
Uses & effectiveness
There is no proven or accepted medicinal use for hemlock water dropwort. In the past, some people applied it to the skin in folk remedies, but this practice is dangerous and is not supported by evidence.
Most modern scientific interest in the plant comes from toxicology — the study of poisons — rather than from any health benefit. Researchers have studied it to understand how its toxins affect the body and to learn how to treat poisoned patients.
In short, there is no condition for which this plant should be used. Any claimed benefit is far outweighed by the very real risk of death.
How it works
The plant contains powerful natural toxins, most notably oenanthotoxin. This compound interferes with the chemical messengers in the nervous system, especially a signal called GABA that normally helps calm nerve activity.
When that calming signal is blocked, the nervous system becomes overactive. This can trigger violent seizures and disrupt the normal rhythm of the heart. The roots tend to hold the highest concentration of toxin, which is why root poisonings are especially dangerous.
These effects are well documented in human poisoning cases and in laboratory research. This is not a theoretical risk — it is a confirmed, serious poison.
Safety & precautions
Hemlock water dropwort should never be eaten, brewed into tea, juiced, or taken in any form. Poisonings often happen when foragers confuse the roots with edible plants.
If you spend time near streams, ditches, or wetlands, learn to recognize this plant and keep children and pets away from it. Touching the plant and then your mouth, or handling cut roots, can be risky.
It is unsafe during pregnancy and breastfeeding, just as it is unsafe for everyone else. If you suspect someone has eaten any part of this plant, treat it as a medical emergency and call your local poison control center or emergency services immediately.
Side effects
Poisoning can come on quickly and may include nausea, vomiting, excess saliva, sweating, and stomach pain. These early signs can rapidly progress to far more serious effects.
Severe poisoning can cause violent seizures, loss of consciousness, irregular heartbeat, breathing failure, and death. People affected by this plant have sometimes been found with a fixed grimace, a feature historically linked to its poisoning.
Because the toxin is so potent, there is no safe amount. Any exposure should be taken seriously.
Hemlock Water Dropwort: Reported Adverse Effects
Documented safety reports on Hemlock Water Dropwort from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, hemlock water dropwort root can cause nausea, dizziness,, abdominal pain, vomiting, sweating, salivation, weakness, confusion, slurred speech, muscle spasms, tonic-clonic movements, glycosuria, hematuria, hyperventilation, cyanosis, exhaustion, seizures, metabolic acidosis, generalized convulsions, unconsciousness, dilated pupils, cardiac arrest , respiratory depression, and death. There is no known antidote for hemlock water dropwort poisoning.
- Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26.
- Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5.
- Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657.
- Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11.
Cardiac arrest Cardiovascular
Orally, hemlock water dropwort root can cause cardiac arrest. In a case report, a 63-year-old male suffered cardiac arrest, grand mal seizure, and severe metabolic acidosis after mistakenly eating hemlock water dropwort roots that he thought were radishes. Supportive care was insufficient and the patient died within a day. There is no known antidote for hemlock water dropwort poisoning.
Depression Pulmonary/Respiratory
Orally, hemlock water dropwort root can cause hyperventilation and respiratory depression.
Epilepsy Musculoskeletal
Orally, hemlock water dropwort root can cause weakness, paralysis, muscle spasms, tonic-clonic movements, seizures, and generalized convulsions.
- Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657.
- Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26.
- Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5.
- Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11.
Epilepsy Neurologic/CNS
Orally, hemlock water dropwort root can cause dizziness, confusion, slurred speech, exhaustion, unconsciousness, tonic-clonic movements, seizures, and generalized convulsions.
- Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26.
- Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657.
- Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5.
Nausea and vomiting Gastrointestinal
Orally, hemlock water dropwort root can cause nausea, salivation, abdominal pain, and vomiting.
- Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26.
- Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5.
- Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657.
- Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no safe dose of hemlock water dropwort. It is a poison, not a supplement, and should never be measured out or taken for any reason.
If you have been given a product that claims to contain this plant, do not use it, and speak with a pharmacist or doctor. The only correct "dose" is none at all.
Hemlock Water Dropwort & Pregnancy
Hemlock Water Dropwort & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Hemlock Water Dropwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Fitzgerald P, Moss N, O'Mahony S, Whelton MJ. Accidental hemlock poisoning. Br Med J (Clin Res Ed) 1987;295:1657. PubMed
- Mitchell MI, Routledge PA. Hemlock water dropwort poisoning-a review. Clin Toxicol 1978;12:417-26. PubMed
- Ball MJ, Flather ML, Forfar JC. Hemlock water dropwort poisoning. Postgrad Med J 1987;63:363-5. PubMed
- Henry FJ, Cadiet J, Javaudin F, Rozec B. Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. J Emerg Med. 2020;59(1):e9-e11. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Hemlock Water Dropwort
1 brand in our database make a supplement containing Hemlock Water Dropwort.
Supplement products with Hemlock Water Dropwort
1 product in our database contain Hemlock Water Dropwort. Open any to see its full ingredient list and every drug interaction we check.
Hemlock Water Dropwort: Common Questions
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Can it be used safely during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Hemlock Water Dropwort
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