Medication interaction hub

What Supplements Interact with Lercanidipine hydrochloride?

Lercanidipine hydrochloride brand name: Zanidip. Every interaction below applies to the brands too.

232 Interactions 7 Major 183 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lercanidipine hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lercanidipine hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lercanidipine (Zanidip) is a calcium channel blocker for high blood pressure, and its supplement list deserves genuine care. 232 interacting ingredients are on file, seven rated major, and most either change how much drug reaches your blood or shift blood pressure directly. Grapefruit is the one most people will meet; it blocks the enzyme that clears lercanidipine, letting levels climb until pressure drops too far. St. John's wort does the opposite, speeding the drug's breakdown so it may simply stop working.

Most of the 183 moderate entries pull in one of the same two directions, adding to the tablet's pressure-lowering effect or pushing pressure back up and undercutting it, and 42 more rate only minor. A handful, activated charcoal included, can bind an oral dose in the gut before it reaches the blood. If you read nothing else, read the seven majors; they are where the real hazard sits.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 183 Minor 42 No known interaction 1,220

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lercanidipine hydrochloride: Top Interactions at a Glance

The Lercanidipine hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 232 interacting ingredients — plus 1,220 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lercanidipine hydrochloride Combinations Today

The Lercanidipine hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Calcium + Lercanidipine hydrochloridei

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Read the full interaction Major Likelihood Probable Coleus + Lercanidipine hydrochloridei

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Read the full interaction Moderate Likelihood Probable Wine + Lercanidipine hydrochloridei

Theoretically, concomitant use may interfere with blood pressure control.

Read the full interaction Moderate Likelihood Possible Cannabis + Lercanidipine hydrochloridei

Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Celery + Lercanidipine hydrochloridei

Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Lercanidipine hydrochloridei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Lercanidipine hydrochloride

All 1,452 ingredients in our database, ranked by severity — 232 with a Lercanidipine hydrochloride interaction on file and 1,220 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lercanidipine hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Lercanidipine hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Full Calcium + Lercanidipine hydrochloride answer

Can you take Coleus with Lercanidipine hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Full Coleus + Lercanidipine hydrochloride answer

Can you take Wine with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Wine + Lercanidipine hydrochloride answer

Can you take Cannabis with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Lercanidipine hydrochloride answer

Can you take Celery with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Lercanidipine hydrochloride answer

Can you take Garden Cress with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.

Full Garden Cress + Lercanidipine hydrochloride answer

Can you take Garlic with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.

Full Garlic + Lercanidipine hydrochloride answer

Can you take Gentian with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Full Gentian + Lercanidipine hydrochloride answer

Can you take German Chamomile with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Lercanidipine hydrochloride answer

Can you take Ginger with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Lercanidipine hydrochloride answer

Can you take Ginkgo with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Lercanidipine hydrochloride answer

Can you take Goji with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Full Goji + Lercanidipine hydrochloride answer

Can you take Goldenseal with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.

Full Goldenseal + Lercanidipine hydrochloride answer

Can you take Goldthread with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Lercanidipine hydrochloride answer

Can you take Grape with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Lercanidipine hydrochloride answer

Can you take Guar Gum with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Lercanidipine hydrochloride answer

Can you take Guarumo with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intrav...

Full Guarumo + Lercanidipine hydrochloride answer

Can you take Gum Arabic with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Lercanidipine hydrochloride answer

Can you take Hawthorn with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.

Full Hawthorn + Lercanidipine hydrochloride answer

Can you take Hesperidin with Lercanidipine hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.

Full Hesperidin + Lercanidipine hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lercanidipine hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lercanidipine hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lercanidipine hydrochloride sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Lercanidipine hydrochloride through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Lercanidipine hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lercanidipine hydrochloride through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Lercanidipine hydrochloride through this category.

Related: does Lercanidipine hydrochloride deplete any nutrients?

Lercanidipine hydrochloride has 2 reported nutrient associations in the research literature — see the Lercanidipine hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lercanidipine hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lercanidipine hydrochloride.

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Pharmacist Counseling Corner

Lercanidipine hydrochloride & Supplements: Common Questions

What supplements interact with Lercanidipine hydrochloride?
In our interaction database, 232 supplement and herbal ingredients have an interaction with Lercanidipine hydrochloride on file — 7 rated major, 183 moderate, and 42 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Grapefruit, Tyramine.
Which Lercanidipine hydrochloride supplement interactions are the most serious?
The 7 major-rated combinations — led by American Hellebore, Grapefruit, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lercanidipine hydrochloride?
That depends entirely on which supplement. The honest answer for Lercanidipine hydrochloride is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zanidip have the same supplement interactions as Lercanidipine hydrochloride?
Yes — Zanidip all contain Lercanidipine hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lercanidipine hydrochloride deplete any vitamins or nutrients?
It might — Lercanidipine hydrochloride has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lercanidipine hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lercanidipine hydrochloride and my other medications?
This page covers Lercanidipine hydrochloride against supplements and herbal ingredients. Checking Lercanidipine hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.