Medication interaction hub

What Supplements Interact with Nisoldipine?

Nisoldipine brand name: Sular. Every interaction below applies to the brands too.

232 Interactions 7 Major 183 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nisoldipine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nisoldipine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nisoldipine (Sular) lowers blood pressure by relaxing blood vessels, and the liver enzyme CYP3A4 controls how fast the body clears it, which is why this list warrants real vigilance. Grapefruit can drive nisoldipine levels up, while St. John's wort speeds its breakdown and can leave the drug too weak to do its job. Most of the 232 ingredients on file either interfere with that enzyme or carry a blood pressure effect of their own that stacks with, or works against, the medication.

Seven entries rate major, and those are worth understanding before the rest, with 183 moderate and 42 minor behind them. The moderate group is dominated by herbs, oils, and everyday foods that nudge pressure lower or higher. A smaller set, activated charcoal included, can trap the drug in the gut before it absorbs, so products like that belong well apart from each dose.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 183 Minor 42 No known interaction 1,220

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nisoldipine: Top Interactions at a Glance

The most significant Nisoldipine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 232 interacting ingredients — plus 1,220 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nisoldipine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Nisoldipinei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Grapefruit + Nisoldipinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Tyramine + Nisoldipinei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Nisoldipinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Nisoldipinei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Coleus + Nisoldipinei

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Read the full interaction
The complete list

Every Supplement Checked Against Nisoldipine

All 1,452 ingredients in our database, ranked by severity — 232 with a Nisoldipine interaction on file and 1,220 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nisoldipine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Nisoldipine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Full Calcium + Nisoldipine answer

Can you take Black Seed with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Nisoldipine answer

Can you take Corydalis Yanhusuo with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might have additive effects with antihypertensive drugs.

Full Corydalis Yanhusuo + Nisoldipine answer

Can you take Cranberry with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Nisoldipine answer

Can you take Cubebs with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Nisoldipine answer

Can you take Danshen with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Full Danshen + Nisoldipine answer

Can you take Devil's Claw with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Nisoldipine answer

Can you take Dhea with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Nisoldipine answer

Can you take Diosmin with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Nisoldipine answer

Can you take Echinacea with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Nisoldipine answer

Can you take Eucalyptus with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Nisoldipine answer

Can you take European Barberry with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.

Full European Barberry + Nisoldipine answer

Can you take European Mistletoe with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European mistletoe might increase the risk of hypotension when taken with antihypertensive drugs.

Full European Mistletoe + Nisoldipine answer

Can you take Evodia with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Nisoldipine answer

Can you take False Unicorn with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Nisoldipine answer

Can you take Fennel with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Nisoldipine answer

Can you take Fermented Milk with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fermented milk might increase the risk of hypotension when taken with antihypertensive drugs.

Full Fermented Milk + Nisoldipine answer

Can you take Feverfew with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Nisoldipine answer

Can you take Flaxseed with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Full Flaxseed + Nisoldipine answer

Can you take Flaxseed Oil with Nisoldipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Flaxseed Oil + Nisoldipine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nisoldipine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nisoldipine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nisoldipine sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Nisoldipine through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Nisoldipine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nisoldipine through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Nisoldipine through this category.

About Nisoldipine

Nisoldipine is an extended-release calcium channel blocker used to treat high blood pressure (hypertension), alone or with other blood pressure medicines.

Generic name: Nisoldipine  ·  Brand name: Sular.

See the full Nisoldipine drug information

Related: does Nisoldipine deplete any nutrients?

Nisoldipine has 2 reported nutrient associations in the research literature — see the Nisoldipine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nisoldipine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nisoldipine.

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Pharmacist Counseling Corner

Nisoldipine & Supplements: Common Questions

What supplements interact with Nisoldipine?
Our database currently documents 232 ingredients with a known Nisoldipine interaction (7 major, 183 moderate, 42 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 232. The highest-ranked right now: American Hellebore, Grapefruit, Tyramine.
Which Nisoldipine supplement interactions are the most serious?
Focus on the major group: American Hellebore, Grapefruit, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nisoldipine?
Plenty of supplements coexist fine with Nisoldipine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Sular have the same supplement interactions as Nisoldipine?
Yes — Sular all contain Nisoldipine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nisoldipine deplete any vitamins or nutrients?
It might — Nisoldipine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nisoldipine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nisoldipine and my other medications?
This page covers Nisoldipine against supplements and herbal ingredients. Checking Nisoldipine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nisoldipine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.