Medication interaction hub

What Supplements Interact with Amlodipine Besilate?

Amlodipine Besilate brand name: Istin. Every interaction below applies to the brands too.

232 Interactions 7 Major 183 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amlodipine Besilate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amlodipine Besilate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take amlodipine besilate (Istin) to lower blood pressure, then reach for fish oil, CBD, or a morning glass of grapefruit juice without a second thought, and this is a list that deserves genuine care. Seven of its 232 supplement interactions are rated major, with grapefruit the everyday standout because it blocks the enzyme (CYP3A4) that clears amlodipine, letting drug levels climb. Most of the rest either stack with its blood-pressure-lowering effect or change how much of the drug your body actually gets.

St. John's wort works in reverse, speeding that same enzyme so a dose delivers less than it should, while tyramine-rich products can push pressure back up against the drug. Many of the 183 moderate entries are gentle pressure-lowerers like fish oil that add to amlodipine's effect; the 42 minor ones carry less weight. Learn the seven major names first, since the page below spells out each one.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 183 Minor 42 No known interaction 1,220

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amlodipine Besilate: Top Interactions at a Glance

The Amlodipine Besilate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 232 interacting ingredients — plus 1,220 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amlodipine Besilate Combinations Today

The Amlodipine Besilate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Calcium + Amlodipine Besilatei

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Read the full interaction Moderate Likelihood Probable Fish Oil + Amlodipine Besilatei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Magnesium + Amlodipine Besilatei

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Read the full interaction Moderate Likelihood Probable Sodium + Amlodipine Besilatei

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Amlodipine Besilatei

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Apple + Amlodipine Besilatei

Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Read the full interaction
The complete list

Every Supplement Checked Against Amlodipine Besilate

All 1,452 ingredients in our database, ranked by severity — 232 with a Amlodipine Besilate interaction on file and 1,220 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amlodipine Besilate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Amlodipine Besilate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Full Calcium + Amlodipine Besilate answer

Can you take Fish Oil with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Amlodipine Besilate answer

Can you take Magnesium with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Full Magnesium + Amlodipine Besilate answer

Can you take Sodium with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Amlodipine Besilate answer

Can you take Coenzyme Q10 with Amlodipine Besilate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Amlodipine Besilate answer

Can you take Fo-ti with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Amlodipine Besilate answer

Can you take Gamma-aminobutyric Acid (gaba) with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.

Full Gamma-aminobutyric Acid (gaba) + Amlodipine Besilate answer

Can you take Garden Cress with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.

Full Garden Cress + Amlodipine Besilate answer

Can you take Garlic with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.

Full Garlic + Amlodipine Besilate answer

Can you take Gentian with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Full Gentian + Amlodipine Besilate answer

Can you take German Chamomile with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Amlodipine Besilate answer

Can you take Ginger with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Amlodipine Besilate answer

Can you take Ginkgo with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Amlodipine Besilate answer

Can you take Goji with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Full Goji + Amlodipine Besilate answer

Can you take Goldenseal with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.

Full Goldenseal + Amlodipine Besilate answer

Can you take Goldthread with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Amlodipine Besilate answer

Can you take Grape with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Amlodipine Besilate answer

Can you take Guar Gum with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Amlodipine Besilate answer

Can you take Guarumo with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intrav...

Full Guarumo + Amlodipine Besilate answer

Can you take Gum Arabic with Amlodipine Besilate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Amlodipine Besilate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amlodipine Besilate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amlodipine Besilate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amlodipine Besilate sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Amlodipine Besilate through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Amlodipine Besilate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amlodipine Besilate through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Amlodipine Besilate through this category.

Related: does Amlodipine Besilate deplete any nutrients?

Amlodipine Besilate has 2 reported nutrient associations in the research literature — see the Amlodipine Besilate nutrient depletion report.

Check a real product

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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amlodipine Besilate.

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Pharmacist Counseling Corner

Amlodipine Besilate & Supplements: Common Questions

What supplements interact with Amlodipine Besilate?
More than you might expect — 232 in total, though they are far from equal: 7 are rated major, 183 moderate, and 42 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Grapefruit, Tyramine.
Which Amlodipine Besilate supplement interactions are the most serious?
Focus on the major group: American Hellebore, Grapefruit, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Amlodipine Besilate?
Usually yes — most people on Amlodipine Besilate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Istin have the same supplement interactions as Amlodipine Besilate?
Yes — Istin all contain Amlodipine Besilate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amlodipine Besilate deplete any vitamins or nutrients?
It might — Amlodipine Besilate has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amlodipine Besilate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amlodipine Besilate and my other medications?
This page covers Amlodipine Besilate against supplements and herbal ingredients. Checking Amlodipine Besilate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.