Drug & supplement interaction

Date Palm + Amlodipine Besilate

Amlodipine Besilate brand name: Istin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Date Palm and Amlodipine Besilate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Date Palm and Amlodipine Besilate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amlodipine Besilate and Date Palm in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Date Palm at all — not against Amlodipine Besilate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Date Palm safety at a glance

Date Palm overall Generally safe Dates are safe as a food for most people when eaten in normal amounts.
Pregnancy Use caution Dates are a common food, but concentrated supplements or large amounts for inducing labor should be discussed with your doctor first.
Breastfeeding Use caution Eating dates as food is generally fine, but safety of concentrated supplements is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amlodipine Besilate and Date Palm? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Date Palm and Amlodipine Besilate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Date Palm

    “Orally, date palm fruit is safe when consumed as a food. It has been reported to cause allergic reactions. Orally, date palm pollen appears to be generally well tolerated. When inhaled, allergy to date palm pollen is fairly common.”

    Date Palm · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 30204. Kwaasi, A. A., Harfi, H. A., Parhar, R. S., Saleh, S., Collison, K. S., Panzani, R. C., Al Sedairy, S. T., and Al Mohanna, F. A. Cross-reactivities between date palm (Phoenix dactylifera L.) polypeptides and foods implicated in the oral allergy syndrome.
    2. 98654. Elkerm Y, Tawashi R. Date palm pollen as a preventative intervention in radiation- and chemotherapy-induced oral mucositis: a pilot study. Integr Cancer Ther. 2014;13(6):468-72. PubMed
    3. 98655. Rasekh A, Jashni HK, Rahmanian K, Jahromi AS. Effect of palm pollen on sperm parameters of infertile man. Pak J Biol Sci. 2015;18(4):196-9. PubMed
    4. 30207. Bener, A., Safa, W., Abdulhalik, S., and Lestringant, G. G. An analysis of skin prick test reactions in asthmatics in a hot climate and desert environment. Allerg.Immunol.(Paris) 2002;34(8):281-286.
    5. 47102. Blanco, C., Carrillo, T., Quiralte, J., Pascual, C., Martin, Esteban M., and Castillo, R. Occupational rhinoconjunctivitis and bronchial asthma due to Phoenix canariensis pollen allergy. Allergy 1995;50(3):277-280.

    “By inhalation, date palm pollen has been reported to cause allergic rhinitis, wheezing, rhinoconjunctivitis, and bronchial asthma. Orally, date palm fruit has been reported to cause allergic reactions.”

    Date Palm · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    3 sources cited
    1. 30207. Bener, A., Safa, W., Abdulhalik, S., and Lestringant, G. G. An analysis of skin prick test reactions in asthmatics in a hot climate and desert environment. Allerg.Immunol.(Paris) 2002;34(8):281-286.
    2. 47102. Blanco, C., Carrillo, T., Quiralte, J., Pascual, C., Martin, Esteban M., and Castillo, R. Occupational rhinoconjunctivitis and bronchial asthma due to Phoenix canariensis pollen allergy. Allergy 1995;50(3):277-280.
    3. 30204. Kwaasi, A. A., Harfi, H. A., Parhar, R. S., Saleh, S., Collison, K. S., Panzani, R. C., Al Sedairy, S. T., and Al Mohanna, F. A. Cross-reactivities between date palm (Phoenix dactylifera L.) polypeptides and foods implicated in the oral allergy syndrome.

    Amlodipine Besilate

    Listed in the ADVERSE REACTIONS section of the FDA label for Amlodipine Besilate. Read the label on DailyMed ›

Reported for Date Palm but not commonly for Amlodipine Besilate: wheezing and a stuffy or runny nose.

Effects for Amlodipine Besilate come from the ADVERSE REACTIONS section of its FDA label; effects for Date Palm come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Amlodipine Besilate

This page covers Date Palm only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amlodipine Besilate page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 7 major · 183 moderate · 42 minor.

From our pharmacist’s overview on the Amlodipine Besilate page

“People take amlodipine besilate (Istin) to lower blood pressure, then reach for fish oil, CBD, or a morning glass of grapefruit juice without a second thought, and this is a list that deserves genuine care. Seven of its 232 supplement interactions are rated major, with grapefruit the everyday standout because it blocks the enzyme (CYP3…”

Reviewed by 2 · Jul 18, 2026

Open the Amlodipine Besilate interaction page

One more smart check

Taking Date Palm as Part of a Dietary Supplement Product? Check It for Interactions

We hold 112 real supplement products containing Date Palm, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Date Palm. Even though Date Palm itself has no known interaction with Amlodipine Besilate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Date Palm and Amlodipine Besilate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Date Palm
Top half

#643 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amlodipine Besilate
Top 5%

#135 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Date Palm reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Date Palm and Amlodipine Besilate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Date Palm

What is Date Palm?

  • Nutritional energy source
  • Digestive health and constipation
  • Labor support (folk use)
  • Male fertility (pollen, traditional)
  • General wellness and antioxidant support

Date palm fruit is a nutritious food rich in natural sugars, fiber, and antioxidants, and is widely eaten as part of a healthy diet. Beyond its value as food, evidence for medicinal benefits like easing labor or boosting fertility is limited and mostly preliminary. Talk to your pharmacist or doctor before using concentrated date supplements for a health condition.

Phoenix dactylifera · Arecaceae · Fruit (dates), seeds, pollen, and sometimes sap or flowers · Whole fruit, date syrup, date paste, seed powder, capsules, and pollen extracts

An interaction check asks whether these two react with each other — it does not ask whether Date Palm is a good idea for someone in your situation. Here is what our Date Palm record says about it on its own.

Date Palm: dosing

There is no official or standardized medicinal dose for date palm. As a food, dates are eaten according to personal taste and dietary needs, and a few dates make a typical serving.For date supplements, syrups, or pollen products, follow the directions on the product label.

From our Date Palm monograph — the full record covers uses, side effects and every documented interaction.

Read the full Date Palm monograph & all interactions
Keep checking

Other Drugs & Date Palm

Browse every other medication we’ve checked against Date Palm — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Date Palm against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Date Palm list.

See the full Date Palm interactions page
See every supplement checked against Amlodipine Besilate, ranked by severity
Evidence & sources

Date Palm References

The 9 references that drive our Date Palm monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kwaasi, A. A., Harfi, H. A., Parhar, R. S., Saleh, S., Collison, K. S., Panzani, R. C., Al Sedairy, S. T., and Al Mohanna, F. A. Cross-reactivities between date palm (Phoenix dactylifera L.) polypeptides and foods implicated in the oral allergy syndrome.
  2. Bener, A., Safa, W., Abdulhalik, S., and Lestringant, G. G. An analysis of skin prick test reactions in asthmatics in a hot climate and desert environment. Allerg.Immunol.(Paris) 2002;34(8):281-286.
  3. Bauza, E., Dal Farra, C., Berghi, A., Oberto, G., Peyronel, D., and Domloge, N. Date palm kernel extract exhibits antiaging properties and significantly reduces skin wrinkles. Int.J.Tissue React. 2002;24(4):131-136.
  4. Blanco, C., Carrillo, T., Quiralte, J., Pascual, C., Martin, Esteban M., and Castillo, R. Occupational rhinoconjunctivitis and bronchial asthma due to Phoenix canariensis pollen allergy. Allergy 1995;50(3):277-280.
  5. Elkerm Y, Tawashi R. Date palm pollen as a preventative intervention in radiation- and chemotherapy-induced oral mucositis: a pilot study. Integr Cancer Ther. 2014;13(6):468-72. PubMed
  6. Rasekh A, Jashni HK, Rahmanian K, Jahromi AS. Effect of palm pollen on sperm parameters of infertile man. Pak J Biol Sci. 2015;18(4):196-9. PubMed
  7. Bagherzadeh Karimi A, Elmi A, Mirghafourvand M, Baghervand Navid R. Effects of date fruit (Phoenix dactylifera L.) on labor and delivery outcomes: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2020 Apr 14;20(1):210. PubMed
  8. Al Jaouni SK, Hussein A, Alghamdi N, et al. Effects of Phoenix dactylifera Ajwa on infection, hospitalization, and survival among pediatric cancer patients in a university hospital: A nonrandomized controlled trial. Integr Cancer Ther. 2019;18:15347354198
  9. Royani I, As'ad S, Mappaware NA, Hatta M, Rabia. Effect of Ajwa dates consumption to inhibit the progression of preeclampsia threats on mean arterial pressure and roll-over test. Biomed Res Int. 2019 Dec 10;2019:2917895. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Date Palm and Amlodipine Besilate Together: Common Questions

Is it safe to take Date Palm with Amlodipine Besilate?
We do not list a known interaction between Date Palm and Amlodipine Besilate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Date Palm and Amlodipine Besilate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Amlodipine Besilate interact with any supplements?
Yes. Amlodipine Besilate has documented interactions with 232 supplements in our database — Date Palm is not one of them. The Amlodipine Besilate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Date Palm monograph Uses, safety profile, and every drug interaction in one place Amlodipine Besilate supplement interactions Every supplement checked against Amlodipine Besilate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amlodipine Besilate and Date Palm?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.