Medication interaction hub

What Supplements Interact with Nicardipine?

Nicardipine brand names: Cardene, Cardene SR, Cardene IV. Every interaction below applies to the brands too.

243 Interactions 11 Major 191 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nicardipine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nicardipine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nicardipine (Cardene) works by relaxing blood vessels to bring blood pressure down, so a supplement that shifts how much of the drug reaches your blood, or that moves blood pressure on its own, is worth genuine care rather than a shrug. Grapefruit can raise nicardipine levels enough to intensify its effects, while St. John's wort does the reverse, speeding its breakdown and potentially leaving your pressure poorly controlled. Both sit among the major-rated entries, which are the ones to understand before anything else on this page.

Most of the rest echo the same theme more softly. Well over a hundred ingredients, celery seed and cod liver oil among them, lower blood pressure a little on their own, and stacked on nicardipine that can mean dizziness or lightheadedness. A smaller cluster, including ephedra, can affect heart rhythm. The full page runs to 243 ingredients, 191 of them moderate and 41 minor once you set the eleven majors aside.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 191 Minor 41 No known interaction 1,209

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Nicardipine: Top Interactions at a Glance

The Nicardipine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 243 interacting ingredients — plus 1,209 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Nicardipine Combinations Today

The Nicardipine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Calcium + Nicardipinei

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Read the full interaction Major Likelihood Probable Coleus + Nicardipinei

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Nicardipinei

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction Minor Likelihood Possible Passion Flower + Nicardipinei

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Lentinan + Nicardipinei

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Probable Apple + Nicardipinei

Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Read the full interaction
The complete list

Every Supplement Checked Against Nicardipine

All 1,452 ingredients in our database, ranked by severity — 243 with a Nicardipine interaction on file and 1,209 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nicardipine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Nicardipine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.

Full Calcium + Nicardipine answer

Can you take Coleus with Nicardipine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Full Coleus + Nicardipine answer

Can you take Vitamin B6 with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Nicardipine answer

Can you take Passion Flower with Nicardipine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Nicardipine answer

Can you take Lentinan with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Nicardipine answer

Can you take Quercetin with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Full Quercetin + Nicardipine answer

Can you take Rabdosia Rubescens with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Nicardipine answer

Can you take Rauvolfia Vomitoria with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.

Full Rauvolfia Vomitoria + Nicardipine answer

Can you take Rauwolscine with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rauwolscine may have additive coronary vasodilatory effects if used with calcium channel blockers.

Full Rauwolscine + Nicardipine answer

Can you take Red Yeast Rice with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Full Red Yeast Rice + Nicardipine answer

Can you take Rehmannia with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.

Full Rehmannia + Nicardipine answer

Can you take Reishi Mushroom with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Reishi Mushroom + Nicardipine answer

Can you take Resveratrol with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Nicardipine answer

Can you take Rhodiola with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Full Rhodiola + Nicardipine answer

Can you take Rooibos with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Nicardipine answer

Can you take Royal Jelly with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Full Royal Jelly + Nicardipine answer

Can you take Saffron with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Nicardipine answer

Can you take Sage with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Nicardipine answer

Can you take Schizonepeta with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Nicardipine answer

Can you take Sea Buckthorn with Nicardipine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Nicardipine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nicardipine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nicardipine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nicardipine sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Nicardipine through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Nicardipine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nicardipine through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Nicardipine through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Nicardipine through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Nicardipine through this category.

Nicardipine (Cardene) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Nicardipine through this category.

About Nicardipine

Nicardipine is a calcium channel blocker used to treat high blood pressure and chronic stable angina, available as oral capsules and intravenous injection depending on the product.

Generic name: Nicardipine  ·  Brand names: Cardene, Cardene SR, Cardene IV.

See the full Nicardipine drug information

Related: does Nicardipine deplete any nutrients?

Nicardipine has 6 reported nutrient associations in the research literature — see the Nicardipine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nicardipine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nicardipine.

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Pharmacist Counseling Corner

Nicardipine & Supplements: Common Questions

What supplements interact with Nicardipine?
More than you might expect — 243 in total, though they are far from equal: 11 are rated major, 191 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Grapefruit, Tyramine.
Which Nicardipine supplement interactions are the most serious?
Focus on the major group: American Hellebore, Grapefruit, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nicardipine?
Usually yes — most people on Nicardipine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Cardene have the same supplement interactions as Nicardipine?
Yes — Cardene, Cardene SR, Cardene IV all contain Nicardipine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nicardipine deplete any vitamins or nutrients?
It might — Nicardipine has 6 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nicardipine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nicardipine and my other medications?
This page covers Nicardipine against supplements and herbal ingredients. Checking Nicardipine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nicardipine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.