Nicardipine

57 interactions 592 cited references
Also sold as: Cardene Cardene® Cardene® SR
About Nicardipine

Nicardipine is used to treat high blood pressure and to control angina (chest pain). Nicardipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood and o… Read the full Nicardipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nicardipine Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nicardipine Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Nicardipine Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Nicardipine Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Nicardipine Digoxin Cardoxin® An increased risk of bradycardia and an increased risk of complete heart block Details Nicardipine Epirubicin Ellence Increased risk of heart failure Details Nicardipine Fentanyl Transdermal Patch Duragesic® Severe hypotension Details Nicardipine Ketoconazole Topical Extina® Foam Increased calcium channel blockers exposure and an increased risk of calcium channel blockers-related adverse reactions Details Nicardipine Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nicardipine Melphalan Alkeran An increased risk of severe hypotension Details Nicardipine Melphalan Injection Alkeran An increased risk of severe hypotension Details Nicardipine Atazanavir Reyataz An increased risk of cardiotoxicity (prolonged PR interval) Details Nicardipine Carbamazepine Carbatrol Reduced dihydropyridine calcium channel blockers and reduced efficacy of dihydropyridine calcium channel blockers Details Nicardipine Clomipramine Anafranil Increased clomiPRAMINE exposure Details Nicardipine Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nicardipine Cyclosporine Atopica Increased cycloSPORINE exposure Details Nicardipine Dantrolene Dantrium Severe hyperkalemia with cardiovascular collapse Details Nicardipine Darunavir Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Nicardipine Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Nicardipine Fentanyl Severe hypotension Details Nicardipine Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Nicardipine Itraconazole Sporanox An increased risk of congestive heart failure Details Nicardipine Ketoconazole Extina Increased calcium channel blockers exposure and an increased risk of calcium channel blockers-related adverse reactions Details Nicardipine Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nicardipine Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Nicardipine Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Nicardipine Nirmatrelvir Increased calcium channel blocker exposure and an increased risk of hypotension Details Nicardipine Ponesimod Ponvory An increased risk of bradycardia and heart block Details Nicardipine Ritonavir Norvir Increased calcium channel blocker exposure and increased risk of hypotension Details Nicardipine St John's Wort Reduced niCARdipine efficacy Details Nicardipine Tacrolimus Astagraf Increased tacrolimus exposure and an increased risk of toxicity Details Nicardipine Tramadol ConZip Increased traMADol exposure and reduced exposure of the active metabolite Details Nicardipine Vecuronium Enhanced neuromuscular blockade Details Nicardipine Voriconazole Vfend Increased dihydropyridine calcium channel blockers (CCBs) exposure; an increased risk of dihydropyridine CCB-related adverse react... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.