Nisoldipine

86 interactions 1 explained in plain English 605 cited references
Also sold as: Sular Sular®
About Nisoldipine

Nisoldipine is used to treat high blood pressure. Nisoldipine is in a class of medications called calcium channel blockers. It works by relaxing your blood vessels so your heart does not have to pump as hard. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood ves… Read the full Nisoldipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nisoldipine Abametapir Increased exposure of CYP3A4 substrate Details Nisoldipine Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nisoldipine Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Nisoldipine Digoxin Cardoxin® An increased risk of bradycardia and an increased risk of complete heart block Details Nisoldipine Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Nisoldipine Epirubicin Ellence Increased risk of heart failure Details Nisoldipine Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nisoldipine Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Nisoldipine Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Nisoldipine Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Nisoldipine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Nisoldipine Melphalan Alkeran An increased risk of severe hypotension Details Nisoldipine Melphalan Injection Alkeran An increased risk of severe hypotension Details Nisoldipine Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Nisoldipine Adagrasib Krazati Increased CYP3A4 substrate exposure Details Nisoldipine Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Nisoldipine Atazanavir Reyataz An increased calcium channel blocker exposure Details Nisoldipine Avacopan Tavneos Increased CYP3A4 substrate exposure Details Nisoldipine Carbamazepine Carbatrol Reduced dihydropyridine calcium channel blockers and reduced efficacy of dihydropyridine calcium channel blockers Details Nisoldipine Ceritinib Zykadia Increased CYP3A substrate exposure Details Nisoldipine Clarithromycin Biaxin Increased risk of hypotension, acute kidney injury, bradyarrhythmias, lactic acidosis and peripheral edema Details Nisoldipine Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nisoldipine Cobicistat Tybost Increased nisoldipine exposure Details Nisoldipine Conivaptan Vaprisol Increased CYP3A substrate exposure Details Nisoldipine Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Nisoldipine Dantrolene Dantrium Severe hyperkalemia with cardiovascular collapse Details Nisoldipine Erythromycin Erythrocin Stearate An increased calcium channel blocker that are CYP3A4 substrate exposure, an increased calcium channel blocker that are CYP3A4 subs... Details Nisoldipine Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Nisoldipine Fexinidazole An increased CYP3A4 substrate exposure Details Nisoldipine Fluconazole Diflucan Increased nisoldipine exposure and an increased risk for nisoldipine toxicity Details Nisoldipine Fosnetupitant Increased exposure of CYP3A4 substrate Details Nisoldipine Fosphenytoin Cerebyx Reduced nisoldipine exposure Details Nisoldipine Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nisoldipine Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Nisoldipine Lenacapavir Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.