Khat + Lamotrigine
Lamotrigine brand name: Lamictal.
We found no known interaction between Khat and Lamotrigine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Khat and Lamotrigine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lamotrigine and Khat in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Khat safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Lamotrigine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Lamotrigine is filed under 5 classifications — including anticonvulsants, glucuronidated drugs, cns depressants. Khat has documented interactions with 7 drug classes — the most serious being amoxicillin (amoxil, trimox) (major), antihypertensive drugs (moderate) and antipsychotic drugs (moderate) — and none of Lamotrigine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Khat Does Interact With Other Medications
Khat has 4 major, 401 moderate known drug interactions in our database — Lamotrigine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Khat
We haven’t checked that one against Khat yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Khat. Pick one to open its full report.
Khat in Pregnancy & Breastfeeding
When used orally. Khat has been associated with reducing maternal food intake, maternal weight, infant birth weight, and placental blood flow. It has also been associated with an increased risk for chest pain, elevated heart rate, and high blood pressure during pregnancy.
When used orally. Khat has been associated with a reduction in breast milk production. Also, khat contains compounds that are metabolized to norpseudoephedrine, which passes into breast milk; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Khat or Lamotrigine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Khat or Lamotrigine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Avantera Elevate Drug Interaction Concerns ›
- Accidentally Took Two Seroquel During The Day Instead Of One ›
- Is Dandelion Safe With Gabapentin And Lamotrigine? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Lamotrigine
This page covers Khat only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lamotrigine page lists 116 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 92 moderate · 17 minor.
From our pharmacist’s overview on the Lamotrigine page
“Alcohol, ordinary beer or wine, sits at the top of the interaction list for lamotrigine (Lamictal), with well-documented added sedation, and it sets the tone for a list I would treat with real care. Of the 116 supplements and herbs on file, 78 have sedative effects of their own, so the biggest theme by far is stacked drowsiness and slo…”
Reviewed by 2 · Jul 18, 2026
Where Khat and Lamotrigine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#464 of 1,452 supplements looked up here in the last 7 days
#32 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Khat reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Khat and Lamotrigine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Khat
What is Khat?
- Stimulant for energy and alertness
- Euphoria and mood elevation
- Reducing fatigue
- Appetite suppression
- Social and traditional ceremonies
Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problems, mental health effects, and dependence. It is a controlled substance and illegal in the United States and many other countries, so it should not be used.
Catha edulis · Celastraceae · Leaves and young shoots · Fresh leaves for chewing, dried leaves, tea; sometimes smoked
An interaction check asks whether these two react with each other — it does not ask whether Khat is a good idea for someone in your situation. Here is what our Khat record says about it on its own.
Khat: dosing
There is no safe or established dose of khat. It is not a regulated supplement, and the amount of active compounds varies widely depending on the freshness and source of the leaves.Because khat is illegal in the United States and many other countries and carries real health risks, no dosing recommendation can be given.
From our Khat monograph — the full record covers uses, side effects and every documented interaction.
About Lamotrigine
What Is Lamotrigine Used For?
Brand name: Lamictal
Lamotrigine is used to treat several types of seizures in adults and children aged 2 and older — including partial-onset seizures, generalized tonic-clonic (grand mal) seizures, and seizures related to Lennox-Gastaut syndrome. In older teens and adults, it can also be used alone (monotherapy) after transitioning off another seizure medicine.
For adults with bipolar I disorder, lamotrigine is used as a maintenance treatment — meaning it helps delay the return of mood episodes like depression, mania, or mixed states. It is not approved to treat an active manic or mixed episode that's happening right now.
Other Drugs & Khat
Browse every other medication we’ve checked against Khat — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
4 interactions
401 interactions
- Diltiazem ›
- Nifedipine ›
- Phentermine ›
- Methylphenidate ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Phenylpropanolamine ›
- Chloroquine ›
- Nicotine ›
- Hydralazine ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Diethylpropion ›
- Selegiline ›
- Trichlormethiazide ›
- Aripiprazole ›
- Bendroflumethiazide ›
- Caffeine (otc Drug) ›
- Fluphenazine ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Modafinil ›
- Nicardipine ›
- Oxymetazoline Hydrochloride ›
- Prazosin ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
- Asenapine ›
- Atenolol ›
- Betaxolol ›
- Caffeine (prescription Drug) ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorpromazine ›
- Chlorthalidone ›
- Clozapine ›
- Cocaine Hydrochloride (prescription Drug) ›
- Cyclothiazide ›
- Enalapril Maleate ›
- Ephedrine Sulfate ›
- Felodipine ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Irbesartan ›
- Labetalol ›
- Lithium Carbonate (prescription Drug) ›
- Loxapine ›
Showing 60 of 401 moderate interactions — see all 401 on the Khat page.
No interaction 2,424 drugs checked — show the list
We also checked Khat against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Sertraline ›
- Testosterone ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Prednisone ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Pregabalin ›
- Isotretinoin ›
- Azithromycin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
- Mirtazapine ›
- Finasteride ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Levetiracetam ›
Showing the 60 most looked-up of 2,424 medications checked with no known interaction — see the full Khat list.
Khat References
The 47 references that drive our Khat monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Cats A, Scholten P, Meuwissen SGM, et al. Acute Fasciola hepatica infection attributed to chewing khat. Gut 2000;47:584-5.
- Randall T. Khat abuse fuels Somali conflict, drains economy. JAMA 1993;269:12-13. DOI
- Attef, O. A., Ali, A. A., and Ali, H. M. Effect of Khat chewing on the bioavailability of ampicillin and amoxycillin. J.Antimicrob.Chemother. 1997;39(4):523-525. PubMed
- Hassan, N. A., Gunaid, A. A., Abdo-Rabbo, A. A., Abdel-Kader, Z. Y., al Mansoob, M. A., Awad, A. Y., and Murray-Lyon, I. M. The effect of Qat chewing on blood pressure and heart rate in healthy volunteers. Trop.Doct. 2000;30(2):107-108. PubMed
- Al Hadrani, A. M. Khat induced hemorrhoidal disease in Yemen. Saudi.Med.J. 2000;21(5):475-477. DOI
- Giannini, A. J. and Nakoneczie, A. M. Treatment of Khat Addiction with Bromocriptine Mesylate: A Case Report and Review of Cocaine- and Amphetamine-Like Effects. Am J Ther 1995;2(7):487-489. PubMed
- Hassan, N. A., Gunaid, A. A., El Khally, F. M., and Murray-Lyon, I. M. The effect of chewing Khat leaves on human mood. Saudi.Med.J. 2002;23(7):850-853. DOI
- Giannini, A. J., Miller, N. S., and Turner, C. E. Treatment of khat addiction. J.Subst.Abuse Treat. 1992;9(4):379-382. PubMed
- Al Motarreb, A., Briancon, S., Al Jaber, N., Al Adhi, B., Al Jailani, F., Salek, M. S., and Broadley, K. J. Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br J Clin Pharmacol 2005;59(5):574-581. PubMed
- Hassan, N. A., Gunaid, A. A., El Khally, F. M., Al Noami, M. Y., and Murray-Lyon, I. M. Khat chewing and arterial blood pressure. A randomized controlled clinical trial of alpha-1 and selective beta-1 adrenoceptor blockade. Saudi.Med J 2005;26(4):537-541 DOI
- Brenneisen, R., Fisch, H. U., Koelbing, U., Geisshusler, S., and Kalix, P. Amphetamine-like effects in humans of the khat alkaloid cathinone. Br.J.Clin.Pharmacol. 1990;30(6):825-828. PubMed
- Granek, M., Shalev, A., and Weingarten, A. M. Khat-induced hypnagogic hallucinations. Acta Psychiatr.Scand. 1988;78(4):458-461. PubMed
- Nencini, P., Ahmed, A. M., Amiconi, G., and Elmi, A. S. Tolerance develops to sympathetic effects of khat in humans. Pharmacology 1984;28(3):150-154. PubMed
- Jager, A. D. and Sireling, L. Natural history of Khat psychosis. Aust.N.Z.J.Psychiatry 1994;28(2):331-332. PubMed
- Yousef, G., Huq, Z., and Lambert, T. Khat chewing as a cause of psychosis. Br.J.Hosp.Med. 10-4-1995;54(7):322-326.
- Griffiths, P., Gossop, M., Wickenden, S., Dunworth, J., Harris, K., and Lloyd, C. A transcultural pattern of drug use: qat (khat) in the UK. Br.J.Psychiatry 1997;170:281-284. PubMed
- Alhaddad OM, Elsabaawy MM, Rewisha EA, et al. Khat-induced liver injuries: A report of two cases. Arab J Gastroenterol. 2016;17(1):45-8. PubMed
- Alsalahi A, Alshawsh MA, Mohamed R, et al. Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis. J Ethnopharmacol. 2016;186:30-43.
- Baharith H, Zarrin A. Khat - a new precipitating factor for reversible cerebral vasoconstriction syndrome: a case report. J Med Case Rep. 2016;10(1):351. PubMed
- Chapman MH, Kajihara M, Borges G, et al. Severe, acute liver injury and khat leaves. N Engl J Med. 2010;362(17):1642-4. PubMed
- Coton T, Simon F, Oliver M, Kraemer P. Hepatotoxicity of khat chewing. Liver Int. 2011;31(3):434. PubMed
- de Bree LC, Bodelier AG, Verburg GP. Fasciola hepatica as a cause of jaundice after chewing khat: a case report. Neth J Med. 2013;71(9):478-9.
- Forbes MP, Raj AS, Martin J, Lampe G, Powell EE. Khat-associated hepatitis. Med J Aust. 2013;199(7):498-9. PubMed
- Kassim S, Croucher R, al'Absi M. Khat dependence syndrome: a cross sectional preliminary evaluation amongst UK-resident Yemeni khat chewers. J Ethnopharmacol. 2013;146(3):835-41. PubMed
- Martínez-Balzano C, Kohlitz PJ, Chaudhary P, Hegazy H. Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. J Infect. 2013;66(2):184-6. PubMed
- McLean AS, Kot MB. Cardiac collapse associated with the ingestion of khat. Intern Med J. 2011;41(7):579-81. PubMed
- Peevers CG, Moorghen M, Collins PL, Gordon FH, McCune CA. Liver disease and cirrhosis because of Khat chewing in UK Somali men: a case series. Liver Int. 2010;30(8):1242-3. PubMed
- Roelandt P, George C, d'Heygere F, et al. Acute liver failure secondary to khat (Catha edulis)-induced necrotic hepatitis requiring liver transplantation: case report. Transplant Proc. 2011;43(9):3493-5. PubMed
- Tuladhar AM, Boogaarts HD, de Leeuw FE, van Dijk E. Reversible cerebral vasoconstriction syndrome after chewing khat leaves. Cerebrovasc Dis. 2013;36(2):158-9. PubMed
- Manzar MD, Salahuddin M, Sony P, et al. Sleep disturbances and memory impairment among pregnant women consuming khat: An under-recognized problem. Ann Thorac Med. 2017;12(4):247-251. PubMed
- Al-Maweri SA, AlAkhali M. Oral hygiene and periodontal health status among khat chewers. A case-control study. J Clin Exp Dent. 2017;9(5):e629-e634. PubMed
- Issa FH, Al-Habori M, Chance ML. Effect of Khat (Catha edulis) Use on the Bioavailability, Plasma Levels and Antimalarial Activity of Chloroquine. Sultan Qaboos Univ Med J. 2016;16(2):e182-8. PubMed
- Kalakonda B, Al-Maweri SA, Al-Shamiri HM, Ijaz A, Gamal S, Dhaifullah E. Is Khat (Catha edulis) chewing a risk factor for periodontal diseases? A systematic review. J Clin Exp Dent. 2017;9(10):e1264-e1270. PubMed
- Al-Akhali MS, Al-Moraissi EA. Khat chewing habit produces a significant adverse effect on periodontal, oral health: A systematic review and meta-analysis. J Periodontal Res. 2017;52(6):937-945. PubMed
- Sallam MA, Sheikh KA, Baxendale R, Azam MN, Hossain AM, El-Setouhy M. The physiological and ergogenic effects of khat (Catha edulis Forsk) extract. Subst Use Misuse. 2018;53(1):94-100.
- Bede P, El-Kininy N, O'Hara F, Menon P, Finegan E, Healy D. 'Khatatonia' - cathinone-induced hypertensive encephalopathy. Neth J Med. 2017;75(10):448-450.
- Woldeamanuel GG, Geta TG. Impact of chronic khat (Catha edulis Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study. SAGE Open Med 2019;7:2050312118824616.
- Abdulwadoud Alshoabi S, Noman Aljaber N, Omer Hussain A, Mohammed Aloufi K, Gafar Salih S. Khat Chewing Effect on the International Normalized Ratio in Patients with Mechanical Heart Valves under Warfarin Therapy. Pak J Biol Sci 2020;23(11):1487-1491. PubMed
- Badedi M, Darraj H, Hummadi A, et al. Khat Chewing and Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes 2020;13:307-312.
- Hakami T, Mahmoud M, Mohammed B, El-Setouhy M. Effects of khat use on response to antipsychotic medications in patients with newly diagnosed schizophrenia: a retrospective study. East Mediterr Health J 2021;27(4):353-360. PubMed
- Ongeri L, Kirui F, Muniu E, et al. Khat use and psychotic symptoms in a rural Khat growing population in Kenya: a household survey. BMC Psychiatry 2019;19(1):137. PubMed
- Mekuriaw B, Zegeye A, Molla A, Hussen R, Yimer S, Belayneh Z. Prevalence of Common Mental Disorder and Its Association with Khat Chewing among Ethiopian College Students: A Systematic Review and Meta-Analysis. Psychiatry J 2020;2020:1462141. PubMed
- Tesfaye E, Krahl W, Alemayehu S. Khat induced psychotic disorder: case report. Subst Abuse Treat Prev Policy 2020;15(1):27. PubMed
- Palacios Argueta P, Attar B, Sikavi C, Alagiozian-Angelova V, Mishra S. Drug-Induced Liver Injury Caused by "Khat," an Herbal Stimulant. ACG Case Rep J 2020;7(11):e00480. PubMed
- Waters M, Oxner A, Krajden S, Sultanian R. Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male. Case Reports Hepatol 2018;2018:2816907. PubMed
- Patel H, Kumar K, Essrani RK, Niazi M, Makker J, Nayudu SK. Acute Hepatitis in a Yemeni Immigrant Associated with Khat: A "Biological Amphetamine" Carried in Cultures. Clin Pract 2021;11(1):167-173. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Lamotrigine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Lamotrigine as a medicine that can lower these. This is not an interaction with Khat — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Lamotrigine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Khat and Lamotrigine Together: Common Questions
Is it safe to take Khat with Lamotrigine?
Do Khat and Lamotrigine have any of the same side effects?
How was the Khat and Lamotrigine combination checked?
Does Khat interact with any other medications?
Does Lamotrigine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Lamotrigine and Khat?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.