Lamotrigine

22 interactions 2 explained in plain English
Also sold as: Lamictal Subvenite
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Calcifediol Dofetilide Methotrexate Injection Hydroxychloroquine Mercaptopurine
9 Major 9 Moderate 4 Minor
All (22) Major (9) Moderate (9) Minor (4)

Major

Lamotrigine Azathioprine Azasan An increased risk of hepatotoxicity Details Lamotrigine Calcifediol Rayaldee Altered serum levels of calcifediol Details Lamotrigine Dofetilide Tikosyn Increased dofetilide exposure Details Lamotrigine Ezogabine Gabitril Decreased lamotrigine plasma concentrations Details Lamotrigine Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Lamotrigine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Lamotrigine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lamotrigine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Lamotrigine Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Lamotrigine Sertraline Explained An increased risk of lamotrigine toxicity (fatigue, sedation, confusion, decreased cognition) Details Lamotrigine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Lamotrigine Estradiol Delestrogen Reduced lamoTRIgine exposure and an increased risk of seizures Details Lamotrigine Estradiol Topical Divigel Reduced lamoTRIgine exposure and an increased risk of seizures Details Lamotrigine Estradiol Transdermal Patch Alora® Reduced lamoTRIgine exposure and an increased risk of seizures Details Lamotrigine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Lamotrigine Levonorgestrel After banger Reduced lamoTRIgine exposure and an increased risk of seizures Details Lamotrigine Levonorgestrel Intrauterine System Kyleena Reduced lamoTRIgine exposure and an increased risk of seizures Details Lamotrigine Methsuximide Celontin Reduced lamotrigine concentrations and possible loss of seizure control Details

Minor

Lamotrigine Acetaminophen And Codeine Capital® & Codeine Explained Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Acephen Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Injection Acephen Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Rectal Acephen Decreased lamotrigine effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.