Lamotrigine and Ezogabine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lamotrigine
Ezogabine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased lamotrigine plasma concentrations
Interaction Deep Dive
Concomitant use ezogabine with lamotrigine reduced lamotrigine AUC by 18% and increased lamotrigine clearance by 22%1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) The administration of lamotrigine 200 mg/day with ezogabine 600 mg/day decreased the lamotrigine AUC by 18% and increased the lamotrigine clearance by 22% 1.
Common questions
Can I take Lamotrigine and Ezogabine together?
Decreased lamotrigine plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lamotrigine and Ezogabine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Lamotrigine or Ezogabine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: POTIGA(TM) oral tablets, ezogabine oral tablets. GlaxoSMithKline (per FDA), Research Triangle Park, NC, 2011.
Keep reading about Lamotrigine
Keep reading about Ezogabine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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