Lamotrigine

Name: Lamotrigine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

22 interactions 2 explained in plain English

Also sold as: Lamictal Subvenite

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Calcifediol Dofetilide Methotrexate Injection Hydroxychloroquine Mercaptopurine

9 Major 9 Moderate 4 Minor

All (22) Major (9) Moderate (9) Minor (4)

Minor

Lamotrigine Acetaminophen And Codeine Capital® & Codeine Explained Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Acephen Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Injection Acephen Decreased lamotrigine effectiveness Details Lamotrigine Acetaminophen Rectal Acephen Decreased lamotrigine effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.