Drug & supplement interaction

Angelica Archangelica + Modafinil

Modafinil brand names: Provigil, Sparlon, Alertec.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Angelica Archangelica and Modafinil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Angelica Archangelica and Modafinil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Modafinil and Angelica Archangelica in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Angelica Archangelica safety at a glance

Angelica Archangel... overall Use caution Often used in food amounts, but medicinal doses are not well studied and can cause skin sensitivity to sunlight.
Pregnancy Avoid Traditionally thought to affect the uterus and not well studied; best avoided in medicinal amounts.
Breastfeeding Avoid Not enough safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Modafinil and Angelica Archangelica? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Modafinil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Modafinil is filed under 9 classifications — including dopamine agonists, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Angelica Archangelica has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Modafinil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Angelica Archangelica Does Interact With Other Medications

Angelica Archangelica has 335 moderate known drug interactions in our database — Modafinil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Modafinil)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

What to actually watch for

What Angelica Archangelica Itself Has Been Linked To

This is not an interaction — nothing below involves Modafinil. It is the side-effect record for Angelica Archangelica on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Angelica Archangelica, this list is the first place to look.

  • Sun sensitivity Additional detail

    “Orally or topically, Angelica archangelica might cause photosensitivity reactions. Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis" (18).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 13406. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Constipation Additional detail

    “Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 92461. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed
  • A skin rash Additional detail

    Recorded for Angelica Archangelica in the same Natural Medicines adverse-effect record shown under Sun sensitivity above.

Everything above comes from the Natural Medicines adverse-effect record for Angelica Archangelica — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Modafinil’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Modafinil column appears here.

Everything else you take

See Every Supplement That Interacts With Modafinil

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Modafinil page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (major), Ephedra (major), Grapefruit (major) and Peyote (major).

By severity: 8 major · 150 moderate · 39 minor.

From our pharmacist’s overview on the Modafinil page

“Of the 197 supplements and herbs flagged for modafinil (Provigil, Alertec), eight carry a major rating, and those deserve real caution. Most of the rest fall into two themes.”

Reviewed by 2 · Jul 18, 2026

Open the Modafinil interaction page

How much people look this up

Where Angelica Archangelica and Modafinil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,269 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Modafinil
Top half

#1,108 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angelica Archangelica reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Angelica Archangelica and Modafinil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Angelica archangelica · Apiaceae (Umbelliferae) · Root, seeds (fruit), leaves, and essential oil · Tea, dried root, tincture, capsules, essential oil, and as a flavoring in liqueurs

An interaction check asks whether these two react with each other — it does not ask whether Angelica Archangelica is a good idea for someone in your situation. Here is what our Angelica Archangelica record says about it on its own.

Angelica Archangelica: dosing

There is no well-established standardized dose for Angelica archangelica. Traditional preparations include teas made from the dried root or seeds, tinctures, and capsules, but the amount of active compounds can vary widely between products.Because reliable dosing guidelines are lacking, the safest approach is to follow the directions on the product label and not exceed them. Avoid combining it with strong sun exposure or tanning.

From our Angelica Archangelica monograph — the full record covers uses, side effects and every documented interaction.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Modafinil

What Is Modafinil Used For?

Brand names: Provigil, Sparlon, Alertec

Modafinil helps adults stay awake when they have excessive sleepiness linked to narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD). Both Provigil and generic modafinil tablets are labeled for these three uses.

In OSA, it treats the sleepiness only. It does not treat the airway blockage itself. If CPAP (a breathing machine) is your treatment of choice, a full effort to use it should come first and continue during treatment.

See full Modafinil drug information Modafinil NDC codes and packages
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Angelica Archangelica page.

No interaction 2,494 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Modafinil, ranked by severity
Evidence & sources

Angelica Archangelica References

The 3 references that drive our Angelica Archangelica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
  3. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Angelica Archangelica and Modafinil Together: Common Questions

Is it safe to take Angelica Archangelica with Modafinil?
We do not list a known interaction between Angelica Archangelica and Modafinil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Angelica Archangelica and Modafinil combination checked?
Interactions in our licensed database are recorded against drug classes. Modafinil is filed under 9 classifications, and Angelica Archangelica has documented interactions with 1 drug class — none of Modafinil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Angelica Archangelica interact with any other medications?
Yes. Angelica Archangelica has 335 documented drug interactions in our database — Modafinil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Modafinil interact with any supplements?
Yes. Modafinil has documented interactions with 197 supplements in our database — Angelica Archangelica is not one of them. The Modafinil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Angelica Archangelica monograph Uses, safety profile, and every drug interaction in one place Modafinil drug information The full plain-English guide to this medication Modafinil supplement interactions Every supplement checked against Modafinil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Modafinil and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.