Drug & supplement interaction

Angelica Archangelica + Repaglinide

Repaglinide brand names: Prandin, GlucoNorm.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Angelica Archangelica and Repaglinide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Angelica Archangelica and Repaglinide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Repaglinide and Angelica Archangelica in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Angelica Archangelica safety at a glance

Angelica Archangel... overall Use caution Often used in food amounts, but medicinal doses are not well studied and can cause skin sensitivity to sunlight.
Pregnancy Avoid Traditionally thought to affect the uterus and not well studied; best avoided in medicinal amounts.
Breastfeeding Avoid Not enough safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Repaglinide and Angelica Archangelica? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Repaglinide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Repaglinide is filed under 2 classifications — antidiabetes drugs, oral drugs. Angelica Archangelica has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Repaglinide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Angelica Archangelica Does Interact With Other Medications

Angelica Archangelica has 335 moderate known drug interactions in our database — Repaglinide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Repaglinide)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Angelica Archangelica and Repaglinide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation Additional detail

    Angelica Archangelica

    “Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 92461. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

    Repaglinide

    Listed in the ADVERSE REACTIONS section of the FDA label for Repaglinide. Read the label on DailyMed ›

Reported for Angelica Archangelica but not commonly for Repaglinide: sun sensitivity and a skin rash.

Effects for Repaglinide come from the ADVERSE REACTIONS section of its FDA label; effects for Angelica Archangelica come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 7,418 voluntary FDA FAERS reports for Repaglinide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Repaglinide Is Prescribed For, and What Angelica Archangelica Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Repaglinide is a prescription medicine with approved uses on its FDA label. Angelica Archangelica is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Repaglinide is prescribed for: Repaglinide tablets are used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is not for type 1 diabetes or for treating diabetic ketoacidosis (a dangerous buildup of acids in the blood).

Angelica Archangelica has been studied for:

  • Stroke studied, not established Angelica Archangelica has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Angelica Archangelica for stroke

    Although there has been interest in using oral Angelica archangelica for stroke, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Repaglinide on your own; if you are taking Angelica Archangelica for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Repaglinide

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Repaglinide page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Repaglinide page

“Repaglinide (Prandin, GlucoNorm) is taken right before meals to drop blood sugar quickly, and that speed is exactly why this list deserves real respect. Nearly everything on it also acts on blood sugar, usually pushing it lower still and raising the odds of a hypoglycemic crash, though a handful, niacin among them, pull the other way a…”

Reviewed by 2 · Jul 18, 2026

Open the Repaglinide interaction page

How much people look this up

Where Angelica Archangelica and Repaglinide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,321 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Repaglinide
Top half

#945 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angelica Archangelica reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Angelica Archangelica and Repaglinide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Angelica archangelica · Apiaceae (Umbelliferae) · Root, seeds (fruit), leaves, and essential oil · Tea, dried root, tincture, capsules, essential oil, and as a flavoring in liqueurs

An interaction check asks whether these two react with each other — it does not ask whether Angelica Archangelica is a good idea for someone in your situation. Here is what our Angelica Archangelica record says about it on its own.

Angelica Archangelica: dosing

There is no well-established standardized dose for Angelica archangelica. Traditional preparations include teas made from the dried root or seeds, tinctures, and capsules, but the amount of active compounds can vary widely between products.Because reliable dosing guidelines are lacking, the safest approach is to follow the directions on the product label and not exceed them. Avoid combining it with strong sun exposure or tanning.

From our Angelica Archangelica monograph — the full record covers uses, side effects and every documented interaction.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Repaglinide

What Is Repaglinide Used For?

Brand names: Prandin, GlucoNorm

Repaglinide tablets are used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

It is not for type 1 diabetes or for treating diabetic ketoacidosis (a dangerous buildup of acids in the blood).

Most-Reported Side Effects for Repaglinide

From FAERS, the FDA’s public side-effect reporting system (7,418 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hypoglycaemia 794 reports
Acute kidney injury 558 reports
Diarrhea 384 reports
Lactic acidosis 368 reports
Dyspnea 287 reports
See full Repaglinide drug information
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Angelica Archangelica page.

No interaction 2,494 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Repaglinide, ranked by severity
Evidence & sources

Angelica Archangelica References

The 3 references that drive our Angelica Archangelica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
  3. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Angelica Archangelica and Repaglinide Together: Common Questions

Is it safe to take Angelica Archangelica with Repaglinide?
We do not list a known interaction between Angelica Archangelica and Repaglinide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Angelica Archangelica and Repaglinide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Angelica Archangelica and Repaglinide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Angelica Archangelica in each. That is a conversation for your prescriber, especially if Repaglinide is being adjusted to a target.
How was the Angelica Archangelica and Repaglinide combination checked?
Interactions in our licensed database are recorded against drug classes. Repaglinide is filed under 2 classifications, and Angelica Archangelica has documented interactions with 1 drug class — none of Repaglinide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Angelica Archangelica interact with any other medications?
Yes. Angelica Archangelica has 335 documented drug interactions in our database — Repaglinide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Repaglinide interact with any supplements?
Yes. Repaglinide has documented interactions with 256 supplements in our database — Angelica Archangelica is not one of them. The Repaglinide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Angelica Archangelica monograph Uses, safety profile, and every drug interaction in one place Repaglinide drug information The full plain-English guide to this medication Repaglinide supplement interactions Every supplement checked against Repaglinide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Repaglinide and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.