Repaglinide

Generic name: Pronounced as (re pag' lin ide)
Brand names
  • Prandin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2016

Repaglinide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Repaglinide helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to release insulin.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems.Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Repaglinide comes as a tablet to take by mouth. The tablets are taken before meals, any time from 30 minutes before a meal to just before the meal. If you skip a meal, you need to skip the dose of repaglinide. If you add an extra meal, you need to take an extra dose of repaglinide. Your doctor may gradually increase your dose, depending on your response to repaglinide. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take repaglinide exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Continue to take repaglinide even if you feel well. Do not stop taking repaglinide without talking to your doctor.

Before taking repaglinide,

  • tell your doctor and pharmacist if you are allergic to repaglinide or any other drugs.

  • tell your doctor if you are taking gemfibrozil (Lopid). Your doctor will probably tell you not to take repaglinide if you are taking this medication.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetophenazine (Tindal), aspirin, blood pressure medicines, carbamazepine (Tegretol), chloramphenicol (Chloromycetin), chlorpromazine (Thorazine), corticosteroids, diuretics ('water pills'), drugs for arthritis, erythromycin, troglitazone (Rezulin), estrogens, fluphenazine (Prolixin), isoniazid (Rifamate), ketoconazole (Nizoral), mesoridazine (Serentil), oral contraceptives, perphenazine (Trilafon), phenelzine (Nardil), phenobarbital (Luminal), phenytoin (Dilantin), probenecid (Benemid), prochlorperazine (Compazine), promazine (Sparine), promethazine (Phenergan), rifampin (Rifadin, Rimactane), thioridazine (Mellaril), tranylcypromine (Parnate), trifluoperazine (Stelazine), triflupromazine (Vesprin), trimeprazine (Temaril), vitamins, or warfarin (Coumadin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had liver or kidney disease or if you have been told you have type I diabetes mellitus.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking repaglinide, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking repaglinide.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet.

Alcohol may cause a decrease in blood sugar. Ask your doctor about the use of alcoholic beverages while you are taking repaglinide.

If you have just begun to eat a meal, take the missed dose as soon as you remember it. However, if you have finished eating, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:

    • shakiness

    • dizziness or lightheadedness

    • sweating

    • nervousness or irritability

    • sudden changes in behavior or mood

    • headache

    • numbness or tingling around the mouth

    • weakness

    • pale skin

    • hunger

    • clumsy or jerky movements

  • If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.

    • confusion

    • seizures

    • loss of consciousness

  • Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

    • extreme thirst

    • frequent urination

    • extreme hunger

    • weakness

    • blurred vision

  • If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms:

    • dry mouth

    • upset stomach and vomiting

    • shortness of breath

    • breath that smells fruity

    • decreased consciousness

  • Repaglinide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • nasal congestion

    • joint aches

    • back pain

    • constipation

    • diarrhea

Keep this medication in the container it came in, tightly closed and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to repaglinide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Prandimet® (containing Metformin, Repaglinide)

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Repaglinide can be increased when used in combination with Moxifloxacin.
Montelukast Montelukast The metabolism of Repaglinide can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Repaglinide.
Leflunomide Leflunomide The serum concentration of Repaglinide can be increased when it is combined with Leflunomide.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Repaglinide.
Candesartan Candesartan The metabolism of Repaglinide can be decreased when combined with Candesartan.
Clopidogrel Clopidogrel The risk or severity of hypoglycemia can be increased when Clopidogrel is combined with Repaglinide.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Repaglinide can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Repaglinide can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Repaglinide.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Repaglinide.
Paregoric Paregoric The metabolism of Repaglinide can be decreased when combined with Morphine.
Penbutolol Penbutolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Acebutolol.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Repaglinide.
Reserpine Reserpine Reserpine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Repaglinide can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Tacrolimus can be decreased when used in combination with Repaglinide.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Repaglinide.
Fluconazole Injection Fluconazole Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Fluconazole.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Repaglinide can be increased when used in combination with Levofloxacin.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Repaglinide.
Metronidazole Injection Metronidazole Injection The metabolism of Repaglinide can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Repaglinide can be decreased when combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Repaglinide can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may increase the hypoglycemic activities of Repaglinide.
Cyclosporine Cyclosporine The serum concentration of Repaglinide can be increased when it is combined with Cyclosporine.
Torsemide Torsemide The therapeutic efficacy of Repaglinide can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Olanzapine.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Hydroxychloroquine can be increased when used in combination with Repaglinide.
Pantoprazole Pantoprazole The excretion of Repaglinide can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan Repaglinide may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Anakinra Anakinra The metabolism of Repaglinide can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Repaglinide.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Repaglinide.
Etanercept Injection Etanercept Injection The metabolism of Repaglinide can be increased when combined with Etanercept.
Sirolimus Sirolimus The serum concentration of Repaglinide can be increased when it is combined with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Epinephrine.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Escitalopram.
Olmesartan Olmesartan Olmesartan may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Zonisamide Zonisamide The therapeutic efficacy of Repaglinide can be increased when used in combination with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Repaglinide can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Repaglinide can be decreased when used in combination with Aripiprazole.
Ezetimibe Ezetimibe Repaglinide may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Repaglinide.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Repaglinide can be increased when used in combination with Rosuvastatin.
Tegaserod Tegaserod The metabolism of Repaglinide can be decreased when combined with Tegaserod.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Repaglinide can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Repaglinide can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone Progesterone may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Repaglinide can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Repaglinide can be increased when combined with Infliximab.
Oxandrolone Oxandrolone Oxandrolone may increase the hypoglycemic activities of Repaglinide.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Repaglinide.
Rifaximin Rifaximin The metabolism of Repaglinide can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Repaglinide.
Norethindrone Norethindrone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Bosentan Bosentan Bosentan may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Repaglinide can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Repaglinide can be decreased when combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Insulin aspart.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypoglycemic activities of Repaglinide.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Pramlintide.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Exenatide.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Repaglinide.
Pregabalin Pregabalin The risk or severity of hypoglycemia can be increased when Pregabalin is combined with Repaglinide.
Deferasirox Deferasirox The serum concentration of Repaglinide can be increased when it is combined with Deferasirox.
Tipranavir Tipranavir Repaglinide may decrease the excretion rate of Tipranavir which could result in a higher serum level.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Insulin detemir.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Repaglinide can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the hypoglycemic activities of Repaglinide.
Imatinib Imatinib The metabolism of Repaglinide can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Repaglinide.
Paliperidone Paliperidone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Paliperidone.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Insulin glulisine.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Repaglinide.
Darunavir Darunavir The therapeutic efficacy of Darunavir can be decreased when used in combination with Repaglinide.
Nabilone Nabilone The metabolism of Repaglinide can be decreased when combined with Nabilone.
Vorinostat Vorinostat The therapeutic efficacy of Repaglinide can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib The metabolism of Repaglinide can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Repaglinide can be decreased when combined with Lapatinib.
Ivermectin Ivermectin The excretion of Repaglinide can be decreased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Repaglinide can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Repaglinide can be increased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Repaglinide can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Budesonide is combined with Repaglinide.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Desvenlafaxine.
Nebivolol Nebivolol The therapeutic efficacy of Nebivolol can be increased when used in combination with Repaglinide.
Tretinoin Tretinoin The metabolism of Repaglinide can be decreased when combined with Tretinoin.
Certolizumab Injection Certolizumab Injection The metabolism of Repaglinide can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The serum concentration of Repaglinide can be increased when it is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The excretion of Repaglinide can be decreased when combined with Irinotecan.
Eltrombopag Eltrombopag The metabolism of Repaglinide can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Milnacipran.
Betaxolol Betaxolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Iloperidone.
Everolimus Everolimus The serum concentration of Repaglinide can be increased when it is combined with Everolimus.
Dronedarone Dronedarone The excretion of Dronedarone can be decreased when combined with Repaglinide.
Saxagliptin Saxagliptin The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Saxagliptin.
Golimumab Injection Golimumab Injection The metabolism of Repaglinide can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Repaglinide.
Asenapine Asenapine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Asenapine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Repaglinide.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Repaglinide can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Repaglinide can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Repaglinide.
Lurasidone Lurasidone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Lurasidone.
Linagliptin Linagliptin The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Linagliptin.
Rilpivirine Rilpivirine The excretion of Rilpivirine can be decreased when combined with Repaglinide.
Telaprevir Telaprevir The excretion of Repaglinide can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Repaglinide can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Repaglinide can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Triptorelin.
Vemurafenib Vemurafenib The metabolism of Repaglinide can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Repaglinide can be decreased when combined with Vismodegib.
Axitinib Axitinib The excretion of Repaglinide can be decreased when combined with Axitinib.
Enzalutamide Enzalutamide The metabolism of Repaglinide can be decreased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Repaglinide can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Repaglinide can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Repaglinide.
Teriflunomide Teriflunomide The serum concentration of Repaglinide can be increased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Repaglinide can be decreased when combined with Cabozantinib.
Alogliptin Alogliptin The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Alogliptin.
Ponatinib Ponatinib The metabolism of Repaglinide can be decreased when combined with Ponatinib.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Repaglinide.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Repaglinide.
Methazolamide Methazolamide The therapeutic efficacy of Repaglinide can be increased when used in combination with Methazolamide.
Dabrafenib Dabrafenib The metabolism of Repaglinide can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Repaglinide can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Repaglinide.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Repaglinide.
Ketorolac Injection Ketorolac Injection The metabolism of Repaglinide can be decreased when combined with Ketorolac.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Repaglinide.
Apremilast Apremilast The metabolism of Repaglinide can be increased when combined with Apremilast.
Ceritinib Ceritinib The therapeutic efficacy of Repaglinide can be decreased when used in combination with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Repaglinide can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Albiglutide.
Idelalisib Idelalisib The excretion of Repaglinide can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection Testosterone may increase the hypoglycemic activities of Repaglinide.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Empagliflozin.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Dulaglutide.
Caspofungin Injection Caspofungin Injection The excretion of Repaglinide can be decreased when combined with Caspofungin.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Repaglinide.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Repaglinide can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Repaglinide.
Lenvatinib Lenvatinib Lenvatinib may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection The serum concentration of Repaglinide can be increased when it is combined with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Repaglinide which could result in a lower serum level and potentially a reduction in efficacy.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Repaglinide.
Daclatasvir Daclatasvir The excretion of Repaglinide can be decreased when combined with Daclatasvir.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Repaglinide can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Ziprasidone.
Eluxadoline Eluxadoline The excretion of Repaglinide can be decreased when combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Insulin degludec.
Rifapentine Rifapentine The metabolism of Repaglinide can be increased when combined with Rifapentine.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Repaglinide.
Venetoclax Venetoclax The excretion of Repaglinide can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The excretion of Repaglinide can be decreased when combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Repaglinide.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Repaglinide can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The excretion of Repaglinide can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Lixisenatide.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Repaglinide.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the hypoglycemic activities of Repaglinide.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Repaglinide.
Safinamide Safinamide Safinamide may increase the hypoglycemic activities of Repaglinide.
Midostaurin Midostaurin The metabolism of Repaglinide can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Repaglinide can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The therapeutic efficacy of Repaglinide can be increased when used in combination with Delafloxacin.
Letermovir Letermovir Letermovir may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Semaglutide.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Repaglinide can be increased when used in combination with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Repaglinide.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Repaglinide.
Avatrombopag Avatrombopag The metabolism of Repaglinide can be increased when combined with Avatrombopag.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Repaglinide.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Repaglinide.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Repaglinide.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Repaglinide.
Rifamycin Rifamycin The metabolism of Repaglinide can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Repaglinide can be increased when combined with Emapalumab.
Alpelisib Alpelisib The metabolism of Repaglinide can be decreased when combined with Alpelisib.
Triclabendazole Triclabendazole The metabolism of Repaglinide can be decreased when combined with Triclabendazole.
Pexidartinib Pexidartinib The excretion of Repaglinide can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Repaglinide.
Pitolisant Pitolisant The serum concentration of Repaglinide can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The excretion of Repaglinide can be decreased when combined with Fedratinib.
Phenytoin Injection Phenytoin Injection The metabolism of Repaglinide can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Repaglinide.
Bempedoic Acid Bempedoic Acid The excretion of Repaglinide can be decreased when combined with Bempedoic acid.
Cenobamate Cenobamate The serum concentration of Repaglinide can be decreased when it is combined with Cenobamate.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Teprotumumab.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Repaglinide.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Repaglinide.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Repaglinide.
Remdesivir Injection Remdesivir Injection The excretion of Repaglinide can be decreased when combined with Remdesivir.
Selpercatinib Selpercatinib The serum concentration of Repaglinide can be increased when it is combined with Selpercatinib.
Fostemsavir Fostemsavir The excretion of Repaglinide can be decreased when combined with Fostemsavir.
Octreotide Octreotide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Repaglinide may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Opicapone Opicapone The metabolism of Repaglinide can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Repaglinide can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Repaglinide can be decreased when used in combination with Drospirenone.
Theophylline Theophylline The metabolism of Repaglinide can be decreased when combined with Theophylline.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid The metabolism of Repaglinide can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Repaglinide can be decreased when combined with Naproxen.
Phenobarbital Phenobarbital The metabolism of Repaglinide can be increased when combined with Phenobarbital.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Repaglinide.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Bromocriptine.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Repaglinide.
Phenelzine Phenelzine The metabolism of Repaglinide can be decreased when combined with Phenelzine.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Repaglinide.
Dapsone Dapsone The metabolism of Repaglinide can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Repaglinide can be increased when used in combination with Sulfadiazine.
Methadone Methadone The metabolism of Repaglinide can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Repaglinide can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Repaglinide.
Phentermine Phentermine The therapeutic efficacy of Repaglinide can be increased when used in combination with Phentermine.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Repaglinide.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Repaglinide.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Repaglinide.
Doxorubicin Doxorubicin Repaglinide may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Warfarin Warfarin The metabolism of Repaglinide can be decreased when combined with Warfarin.
Loperamide Loperamide The metabolism of Repaglinide can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin Daunorubicin may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Repaglinide can be increased when combined with Griseofulvin.
Digoxin Digoxin Repaglinide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Repaglinide can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Repaglinide can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Repaglinide.
Sulfinpyrazone Sulfinpyrazone The metabolism of Repaglinide can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Repaglinide can be decreased when used in combination with Metolazone.
Clindamycin Injection Clindamycin Injection The serum concentration of Repaglinide can be increased when it is combined with Clindamycin.
Secobarbital Secobarbital The metabolism of Repaglinide can be increased when combined with Secobarbital.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Repaglinide.
Amitriptyline Amitriptyline The metabolism of Repaglinide can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Repaglinide.
Probenecid Probenecid The therapeutic efficacy of Repaglinide can be increased when used in combination with Probenecid.
Quinidine Quinidine Repaglinide may decrease the excretion rate of Quinidine which could result in a higher serum level.
Rifampin Rifampin The serum concentration of Repaglinide can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Repaglinide.
Valproic Acid Valproic Acid The metabolism of Repaglinide can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen Tamoxifen may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Repaglinide.
Liothyronine Liothyronine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Liothyronine.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Chlorpropamide is combined with Repaglinide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Repaglinide.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Tolazamide is combined with Repaglinide.
Niacin Niacin The therapeutic efficacy of Repaglinide can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Repaglinide can be decreased when used in combination with Baclofen.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Hydrochlorothiazide.
Danazol Danazol The therapeutic efficacy of Repaglinide can be decreased when used in combination with Danazol.
Disulfiram Disulfiram Disulfiram may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Repaglinide can be increased when used in combination with Propranolol.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Repaglinide.
Spironolactone Spironolactone The metabolism of Repaglinide can be decreased when combined with Spironolactone.
Nadolol Nadolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Nadolol.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Repaglinide.
Fluorouracil Injection Fluorouracil Injection The metabolism of Repaglinide can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Repaglinide can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Repaglinide can be increased when used in combination with Acetazolamide.
Nystatin Nystatin The excretion of Repaglinide can be decreased when combined with Nystatin.
Ketoconazole Ketoconazole The serum concentration of Repaglinide can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection Vincristine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Dipyridamole Dipyridamole Repaglinide may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Repaglinide can be decreased when used in combination with Etacrynic acid.
Metoprolol Metoprolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Metoprolol.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Repaglinide.
Trimethoprim Trimethoprim The serum concentration of Repaglinide can be increased when it is combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Repaglinide can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Repaglinide can be decreased when combined with Nifedipine.
Timolol Timolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Timolol.
Verapamil Verapamil The metabolism of Repaglinide can be decreased when combined with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Pindolol.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Repaglinide.
Piroxicam Piroxicam The metabolism of Repaglinide can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Repaglinide can be increased when used in combination with Bumetanide.
Glyburide Glyburide Glyburide may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Glipizide Glipizide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Glipizide.
Indapamide Indapamide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Indapamide.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Pentamidine.
Labetalol Labetalol The therapeutic efficacy of Repaglinide can be increased when used in combination with Labetalol.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Repaglinide can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil The serum concentration of Repaglinide can be increased when it is combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Repaglinide can be decreased when combined with Ketoprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Repaglinide.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Repaglinide.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Repaglinide can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Repaglinide.
Diclofenac Diclofenac The metabolism of Repaglinide can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of hypoglycemia can be increased when Fluoxetine is combined with Repaglinide.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Repaglinide.
Clozapine Clozapine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Clozapine.
Ofloxacin Ofloxacin The therapeutic efficacy of Repaglinide can be increased when used in combination with Ofloxacin.
Clarithromycin Clarithromycin The serum concentration of Repaglinide can be increased when it is combined with Clarithromycin.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Repaglinide.
Felodipine Felodipine The metabolism of Repaglinide can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Repaglinide.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Repaglinide.
Rifabutin Rifabutin The metabolism of Repaglinide can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Repaglinide.
Bisoprolol Bisoprolol The therapeutic efficacy of Repaglinide can be increased when used in combination with Bisoprolol.
Isradipine Isradipine Isradipine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Repaglinide can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Repaglinide can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Repaglinide can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Repaglinide.
Fluvoxamine Fluvoxamine The risk or severity of hypoglycemia can be increased when Fluvoxamine is combined with Repaglinide.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of hypoglycemia can be increased when Lamotrigine is combined with Repaglinide.
Losartan Losartan The metabolism of Repaglinide can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Repaglinide can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Repaglinide can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Repaglinide can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Repaglinide can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Repaglinide.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Nisoldipine is combined with Repaglinide.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Repaglinide.
Glimepiride Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Repaglinide.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Repaglinide.
Indinavir Indinavir Repaglinide may decrease the excretion rate of Indinavir which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Repaglinide can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Repaglinide.
Zafirlukast Zafirlukast The metabolism of Repaglinide can be decreased when combined with Zafirlukast.
Valsartan Valsartan The excretion of Repaglinide can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Repaglinide.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Loratadine Loratadine The metabolism of Repaglinide can be decreased when combined with Loratadine.
Carvedilol Carvedilol The therapeutic efficacy of Carvedilol can be increased when used in combination with Repaglinide.
Nilutamide Nilutamide The metabolism of Repaglinide can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Repaglinide.
Sertraline Sertraline The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Sertraline.
Propafenone Propafenone The therapeutic efficacy of Repaglinide can be increased when used in combination with Propafenone.
Raloxifene Raloxifene The metabolism of Repaglinide can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Repaglinide can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The therapeutic efficacy of Repaglinide can be increased when used in combination with Tamsulosin.
Quetiapine Quetiapine The therapeutic efficacy of Repaglinide can be decreased when used in combination with Quetiapine.
Paroxetine Paroxetine The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Repaglinide.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Repaglinide.
Efavirenz Efavirenz The metabolism of Repaglinide can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The excretion of Repaglinide can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Repaglinide can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The therapeutic efficacy of Repaglinide can be increased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Repaglinide can be decreased when combined with Rosiglitazone.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Repaglinide.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Repaglinide.
Rabeprazole Rabeprazole The metabolism of Repaglinide can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Repaglinide can be decreased when combined with Terbinafine.

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