Eletriptan
Eletriptan is a triptan medicine taken by mouth to treat migraine attacks, with or without aura, in adults once they have started.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 15 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Eletriptan (Relpax) is a triptan, a common first prescription choice for stopping a migraine attack in adults once it starts. It works on serotonin receptors to narrow swollen blood vessels in the head and calm pain nerves, and it has been on the U.S. market since about 2002 and is available generically. Most people tolerate it well and mainly notice tiredness, dizziness, nausea or a brief tightness in the chest, throat or jaw, which is usually not heart related. The rare but serious risk is a heart attack or stroke, so get emergency help for chest pain that does not ease, sudden weakness or trouble speaking.
Clinical pearls
- Keep at least 72 hours between eletriptan and clarithromycin, ketoconazole, itraconazole or ritonavir, which greatly raise its levels.
- Do not take another triptan or an ergot medicine such as DHE within 24 hours of a dose.
- It will not prevent migraines or treat cluster headache, and no response on the first attack means rechecking the diagnosis.
- Using it 10 or more days a month can cause rebound (medication overuse) headaches, so track how often you take it.
Patient information guide A plain-language walkthrough of Eletriptan, written from its FDA label.
What Eletriptan is used for
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Eletriptan is used to treat migraine attacks in adults.
- Acute treatment of migraine with or without aura in adults (Eletriptan Hydrobromide, Eletriptan HBR and Relpax tablets)
- Not for preventing migraine attacks
- Not established for cluster headache
- Use only after a clear migraine diagnosis; if the first attack doesn't respond, the diagnosis should be reconsidered
How Eletriptan works
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Eletriptan binds to serotonin receptors (5-HT 1B, 1D and 1F). Its benefit in migraine is thought to come from activating the 1B/1D receptors on blood vessels in the head and on nerves of the trigeminal system.
This narrows the blood vessels and reduces release of pain and inflammation-causing chemicals.
Eletriptan dosage
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Eletriptan tablets are taken by mouth when a migraine starts. They can be taken with or without food.
- If the migraine isn't gone after 2 hours, or it returns, a second dose may be taken at least 2 hours after the first.
- There is a maximum daily amount; do not exceed it.
- Safety of treating more than about 3 attacks in 30 days hasn't been established.
Follow your prescriber's directions and the label.
Dosing details from the FDA-approved label
From the Eletriptan prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Acute treatment of migraine in adults
- Single dose: 20 mg or 40 mg
- If the migraine has not resolved by 2 hours after taking the tablet, or returns after transient improvement, a second dose may be administered at least 2 hours after the first dose
- Maximum: Maximum recommended single dose is 40 mg; maximum daily dose should not exceed 80 mg (not to exceed 80 mg in any 24-hour period)
- Safety of treating an average of more than 3 migraine attacks in a 30-day period has not been established
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION The maximum recommended single dose is 40 mg. In controlled clinical trials, single doses of 20 mg and 40 mg were effective for the acute treatment of migraine in adults. A greater proportion of patients had a response following a 40 mg dose than following a 20 mg dose [see Clinical Studies (14) ] . If the migraine has not resolved by 2 hours after taking eletriptan hydrobromide tablets, or returns after transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose should not exceed 80 mg. The safety of treating an average of more than 3 migraine attacks in a 30-day period has not been established. • Single dose: 20 mg or 40 mg ( 2 ) • Maximum single dose: 40 mg ( 2 ) • May repeat dose after 2 hours if needed; not to exceed 80 mg in any 24-hour period ( 2 )
Read the full Dosage and Administration section on DailyMed →
Eletriptan side effects
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Most side effects are mild and tend to be more common at higher doses.
Common side effects
- Weakness or tiredness (asthenia)
- Nausea
- Dizziness
- Sleepiness (somnolence)
- Dry mouth
- Tingling or prickling feelings (paresthesia)
- Flushing or feeling of warmth
- Chest, throat or jaw tightness or pressure
- Stomach discomfort or indigestion
- Throat tightness or trouble swallowing
When to get medical help
- Get emergency help for chest pain, severe tightness, or signs of a heart attack, especially if it doesn't ease.
- Get emergency help for signs of a stroke or brain bleed, such as sudden weakness, trouble speaking, or a sudden severe headache unlike your usual migraine.
- Seek help for a racing, irregular or dangerous heartbeat. The label says to stop eletriptan if this happens.
- Call right away for stomach pain with bloody diarrhea, or for cold, numb or painful fingers or toes.
- Seek help for signs of serotonin syndrome: agitation, hallucinations, fast heartbeat, fever, muscle twitching or poor coordination, nausea, vomiting or diarrhea.
- Get emergency help for swelling of the face, lips or throat, trouble breathing, or hives, which can be signs of a severe allergic reaction.
- Tell your doctor if you have very high blood pressure readings or if headaches get worse or happen daily while using migraine medicines often.
Seek medical help for chest pain, stroke symptoms, serious allergic reactions, serotonin syndrome signs, or abnormal heartbeat. Seizure and vomiting have also been reported after approval.
Eletriptan warnings and precautions
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- Heart risks: heart attack, coronary spasm and dangerous rhythms have been reported, sometimes in people without known heart disease.
- Stroke and brain bleeds: have occurred with triptans. Unusual headaches need proper evaluation first.
- Other blood vessel spasm: may cause bowel or limb circulation problems, including abdominal pain with bloody diarrhea.
- Blood pressure: can rise significantly, even without a history of high blood pressure.
- Medication overuse headache: possible with 10 or more days a month of acute migraine medicines.
- Serotonin syndrome and severe allergic reactions are possible.
Eletriptan interactions
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Several medicines can make eletriptan unsafe or raise the risk of problems.
- Other triptans and ergot medicines: additive blood vessel narrowing, so keep 24 hours apart.
- Strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin, ritonavir): raise eletriptan levels sharply; wait at least 72 hours.
- SSRIs, SNRIs, tricyclic antidepressants and MAO inhibitors: risk of serotonin syndrome.
- Propranolol: modestly raises eletriptan levels, with no dose change needed.
Interactions listed in the FDA-approved label
From the Eletriptan prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Ergot-containing drugs (ergotamine-containing or ergot-type medications like dihydroergotamine [DHE] or methysergide): Ergot-containing drugs have been reported to cause prolonged vasospastic reactions, and these effects may be additive. Use within 24 hours of each other is contraindicated.
- Other 5-HT1 agonists: Effects may be additive with other 5-HT1 agonists. Concomitant use within 24 hours of eletriptan treatment is contraindicated.
- Potent CYP3A4 inhibitors: Potent CYP3A4 inhibitors significantly increase the exposure of eletriptan. Eletriptan should not be used within at least 72 hours of treatment with potent CYP3A4 inhibitors.
- SSRIs, SNRIs, TCAs and MAO inhibitors: Cases of serotonin syndrome have been reported during co-administration of triptans and these drugs.
Read the label’s full interactions text
7 DRUG INTERACTIONS 7.1 Ergot-Containing Drugs Including Other 5-HT 1B/1D Agonists Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine [DHE] or methysergide) and Eletriptan Hydrobromide Tablets within 24 hours of each other is contraindicated . Concomitant use of other 5-HT 1 agonists within 24 hours of Eletriptan Hydrobromide Tablets treatment is contraindicated [see Contraindications (4) ] . 7.2 CYP3A4 Inhibitors Potent CYP3A4 inhibitors significantly increase the exposure of Eletriptan Hydrobromide Tablets. Eletriptan Hydrobromide Tablets should not be used within at least 72 hours of treatment with potent CYP3A4 inhibitors [see Contraindications (4) and Clinical Pharmacology (12.3) ] . 7.3 Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during co-administration of triptans and SSRIs, SNRIs, TCAs and MAO inhibitors [see Warnings and Precautions (5.7) ].
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Eletriptan
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- Do not use with heart disease, coronary spasm, Wolff-Parkinson-White syndrome, prior stroke or TIA, hemiplegic or basilar migraine, peripheral vascular disease, ischemic bowel disease, or uncontrolled high blood pressure.
- Do not use if allergic to eletriptan.
- Several heart risk factors may call for a heart check first.
- Pregnancy: human data are limited; animal studies showed harm.
- Breastfeeding: it passes into milk; avoiding nursing for 24 hours after a dose can lower infant exposure.
- Children: not established as safe or effective.
- Older adults: blood pressure rose more than in younger people.
- Severe liver impairment: not recommended.
Eletriptan overdose
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There is no specific antidote for eletriptan overdose. People should be monitored for at least 20 hours, or longer if symptoms continue. Call poison control or emergency services right away after taking too much.
How your body processes Eletriptan
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Eletriptan is well absorbed by mouth, with peak levels about 1.5 to 2 hours after a dose. About half reaches the bloodstream. A high-fat meal raises levels by roughly 20 to 30%, but it can be taken with or without food.
The liver enzyme CYP3A4 mainly breaks it down. Its half-life is about 4 hours. Levels rise in mild to moderate liver impairment, and strong CYP3A4 inhibitors raise them substantially.
How to store Eletriptan
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Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) .
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Eletriptan
38 supplements and herbal products have documented interactions with Eletriptan in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 2
- Moderate · 25
- Minor · 11
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Eletriptan: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Eletriptan — the kind of thing our pharmacy team would talk through with you at the counter.
What is eletriptan for?
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How do I take it?
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What side effects should I expect?
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When should I get urgent help?
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Can I take it with my other medicines?
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Is it safe in pregnancy or while breastfeeding?
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Is Eletriptan available over the counter?
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When was Eletriptan first available?
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Who makes Eletriptan?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Eletriptan on HelloPharmacist
Eletriptan forms and strengths (how it comes)
Eletriptan is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Eletriptan inactive ingredients by manufacturer.
Tablet
How this form is used
- Relpax is used for the acute treatment of migraine with or without aura in adults.
- Eletriptan Hydrobromide tablets are used for the acute treatment of migraine with or without aura in adults.
- Eletriptan HBR tablets are used for the acute treatment of migraine with or without aura in adults.
- Relpax is taken by mouth; if the migraine isn't resolved after 2 hours or returns, a second dose may be taken at least 2 hours after the first.
- Eletriptan Hydrobromide tablets can be taken with or without food.
- Eletriptan HBR tablets have a daily maximum that should not be exceeded; follow your prescriber and the label.
Eletriptan on the U.S. market: products, makers and brands
How Eletriptan appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
11 companies list 21 Eletriptan product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 2002. Brand names on the directory include Relpax, Eletriptan Hydrobromide, Eletriptan HBR; the rest are generics.
Also listed with the FDA, not a patient dose form: Powder (8) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Eletriptan is used (Medicaid data)
A general measure of how commonly Eletriptan is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Eletriptan is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Eletriptan prescribed? Of the 1,601 medications we measure, Eletriptan ranks #700 by Medicaid prescriptions — more than 56% of them.
Utilization by Eletriptan product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
eletriptan 40 MG Oral Tablet Most dispensed
Summed across the 9 of 45 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 359494
eletriptan 20 MG Oral Tablet
Summed across the 6 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 359493
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Eletriptan, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 15 of 75 listed Eletriptan NDCs with Medicaid activity.
Compare Eletriptan products
A representative set of FDA-listed product records for Eletriptan — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 40 mg | Oral | Advanced Rx of Tennessee, LLC | ANDA | View NDC → |
| 20 mg | Oral | Apnar Pharma LP | ANDA | View NDC → |
| 40 mg | Oral | Apnar Pharma LP | ANDA | View NDC → |
| 20 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 40 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 40 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 20 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 40 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 40 mg | Oral | Direct_Rx × 2 listings | ANDA | View NDC → |
| 20 mg | Oral | Mylan Pharmaceuticals Inc. | ANDA | View NDC → |
| 40 mg | Oral | Mylan Pharmaceuticals Inc. | ANDA | View NDC → |
| 20 mg | Oral | Teva Pharmaceuticals USA, Inc. | ANDA | View NDC → |
| 40 mg | Oral | Teva Pharmaceuticals USA, Inc. | ANDA | View NDC → |
| 20 mg | Oral | Viatris Specialty LLC | NDA | View NDC → |
| 40 mg | Oral | Viatris Specialty LLC | NDA | View NDC → |
| 20 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 40 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 20 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 40 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
Showing 21 of 21 products — FDA National Drug Code Directory. See every product, package size and price: browse all 21 Eletriptan NDCs →
Eletriptan side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Eletriptan — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Eletriptan in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Eletriptan FDA approval history
How Eletriptan went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Eletriptan recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Eletriptan recalls since July 2021.
✅No Eletriptan recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 231049 1 dose form · 2 strengths
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Dose form (SCDF) Oral Tablet RxCUI 379029In current FDA listings
Look up RxCUI 231049 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Eletriptan supply and shortage status
Whether Eletriptan is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Eletriptan costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet, Film Coated · Oral | 40 mg | $1.75 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 20 mg | $1.73 per tablet | NDC details & price history |
| Tablet · Oral | 20 mg | $77.37 per tablet | NDC details & price history |
| Tablet · Oral | 40 mg | $77.05 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Eletriptan brand names
Eletriptan is sold under 3 brand names in the FDA directory — Relpax, Eletriptan Hydrobromide, Eletriptan HBR. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Eletriptan: manufacturers and labelers
11 companies list Eletriptan products with the FDA. By number of product records, the largest are Apnar Pharma LP, Aurobindo Pharma Limited, Bryant Ranch Prepack. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Eletriptan drug class (RxNorm)
Eletriptan belongs to the Serotonin-1b and Serotonin-1d Receptor Agonist class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Eletriptan page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Viatris Specialty LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →