Armodafinil

Generic name: Pronounced as (ar moe daf' i nil)
Brand names
  • Nuvigil®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2016

Armodafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Armodafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore does not get enough restful sleep). Armodafinil is in a class of medications called wakefulness-promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

Armodafinil comes as a tablet to take by mouth. It is usually taken once a day. If you are taking armodafinil to treat narcolepsy or OSAHS, you will probably take it in the morning. If you are taking armodafinil to treat shift work sleep disorder, you will probably take it 1 hour before the start of your shift. Take armodafinil at around the same time every day. Do not change the time of day that you take armodafinil without talking to your doctor. Talk to your doctor if your work shift does not begin at the same time every day. Follow the directions on your prescription label carefully, and ask our doctor or pharmacist to explain any part you do not understand. Take armodafinil exactly as directed.

Armodafinil may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Armodafinil may decrease your sleepiness, but it will not cure your sleep disorder. Continue to take armodafinil even if you feel well-rested. Do not stop taking armodafinil without talking to your doctor.

Armodafinil should not be used in place of getting enough sleep. Follow your doctor's advice about good sleep habits. Continue to use any breathing devices or other treatments that your doctor has prescribed to treat your condition, especially if you have OSAHS.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking armodafinil,

  • tell your doctor and pharmacist if you are allergic to armodafinil, modafinil (Provigil) or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); clomipramine (Anafranil); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S., E-Mycin, Erythrocin); ketoconazole (Nizoral); omeprazole (Prilosec, in Zegerid); certain medications for seizures such as carbamazepine (Epitol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); midazolam; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); propranolol (Inderal); rifampin (Rifadin, Rimactane, in Rifamate); and triazolam (Halcion). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with armodafinil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs or have overused prescription medications. Also tell your doctor if you have ever had chest pain, an irregular heartbeat, or other heart problems after taking a stimulant, and if you have or have ever had a heart attack; chest pain; high blood pressure; a mental illness such as depression, mania (frenzied, abnormally excited mood), or psychosis (difficulty thinking clearly, communicating, understanding reality, and behaving appropriately); or heart, liver,or kidney disease.

  • you should know that armodafinil may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking armodafinil and for 1 month after you stop taking it. Talk to your doctor about types of birth control that will work for you during and after your treatment with armodafinil.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking armodafinil, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking armodafinil.

  • you should know that armodafinil may affect your judgment, thinking and movement, and may not completely relieve the sleepiness caused by your disorder. Do not drive a car or operate machinery until you know how this medication affects you. If you avoided driving and other dangerous activities because of your sleep disorder, do not start performing these activities again without talking to your doctor even if you feel more alert.

  • be aware that you should avoid drinking alcohol while you are taking this medication.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Armodafinil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • dizziness

    • difficulty falling asleep or staying asleep

    • difficulty concentrating or paying attention

    • uncontrollable shaking of a part of the body

    • numbness, burning, or tingling of the hands or feet

    • nausea

    • vomiting

    • heartburn

    • stomach pain

    • constipation

    • diarrhea

    • loss of appetite

    • thirst

    • dry mouth

    • sweating

    • frequent urination

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • rash

    • blisters

    • peeling skin

    • mouth sores

    • hives

    • itching

    • swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs

    • hoarseness

    • difficulty breathing or swallowing

    • weakness

    • chest pain

    • pounding or irregular heartbeat

    • frenzied, abnormally excited mood

    • hallucinating (seeing things or hearing voices that do not exist)

    • anxiety

    • depression

    • thinking about killing or harming yourself

  • Armodafinil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Store armodafinil in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • agitation

  • difficulty falling asleep or staying asleep

  • restlessness

  • disorientation

  • confusion

  • hallucinating (seeing things or hearing voices that do not exist)

  • nausea

  • diarrhea

  • fast or slow heartbeat

  • chest pain

Keep all appointments with your doctor.

Do not let anyone else take your medication. Selling or giving away armodafinil is against the law. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Armodafinil.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Armodafinil.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Armodafinil.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Armodafinil.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Armodafinil.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Armodafinil.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Armodafinil.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Armodafinil.
Clopidogrel Clopidogrel The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Armodafinil resulting in a loss in efficacy.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Armodafinil.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Armodafinil.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Armodafinil.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Armodafinil.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Armodafinil.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Armodafinil.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be increased when combined with Armodafinil.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Armodafinil.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Armodafinil.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Armodafinil.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be increased when combined with Armodafinil.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Armodafinil.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Armodafinil.
Altretamine Altretamine The risk or severity of hypertension can be increased when Amphetamine is combined with Armodafinil.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Armodafinil.
Ondansetron Ondansetron The metabolism of Ondansetron can be increased when combined with Armodafinil.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Armodafinil.
Olanzapine Olanzapine The metabolism of Olanzapine can be increased when combined with Armodafinil.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Armodafinil.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Armodafinil.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Armodafinil.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Armodafinil.
Zaleplon Zaleplon The metabolism of Zaleplon can be increased when combined with Armodafinil.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Armodafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Armodafinil.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Armodafinil.
Dutasteride Dutasteride The metabolism of Dutasteride can be increased when combined with Armodafinil.
Eplerenone Eplerenone The metabolism of Eplerenone can be increased when combined with Armodafinil.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Armodafinil.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Armodafinil.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Armodafinil.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Armodafinil.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Armodafinil.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Armodafinil.
Vardenafil Vardenafil The metabolism of Vardenafil can be increased when combined with Armodafinil.
Aprepitant Aprepitant The metabolism of Aprepitant can be increased when combined with Armodafinil.
Tadalafil Tadalafil The metabolism of Tadalafil can be increased when combined with Armodafinil.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Armodafinil.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Armodafinil.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Armodafinil.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Armodafinil.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Armodafinil.
Bosentan Bosentan The metabolism of Bosentan can be decreased when combined with Armodafinil.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be increased when combined with Armodafinil.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Armodafinil.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Armodafinil.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Armodafinil.
Dextroamphetamine Dextroamphetamine The risk or severity of hypertension can be increased when Amphetamine is combined with Armodafinil.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Armodafinil.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Armodafinil.
Fentanyl Fentanyl The metabolism of Fentanyl can be increased when combined with Armodafinil.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Armodafinil.
Rasagiline Rasagiline The metabolism of Rasagiline can be increased when combined with Armodafinil.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Armodafinil.
Gefitinib Gefitinib The metabolism of Gefitinib can be increased when combined with Armodafinil.
Paliperidone Paliperidone The metabolism of Paliperidone can be increased when combined with Armodafinil.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Armodafinil.
Primaquine Primaquine The metabolism of Primaquine can be increased when combined with Armodafinil.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Armodafinil.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Armodafinil.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Armodafinil.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Armodafinil.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Armodafinil.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Armodafinil.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Armodafinil.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Armodafinil.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Armodafinil.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Armodafinil.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Armodafinil.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Armodafinil.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Armodafinil.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Armodafinil.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Armodafinil.
Flecainide Flecainide The metabolism of Flecainide can be increased when combined with Armodafinil.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Armodafinil.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Armodafinil.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Armodafinil.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Armodafinil.
Midazolam Midazolam The metabolism of Midazolam can be increased when combined with Armodafinil.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Armodafinil.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Armodafinil.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Armodafinil.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Armodafinil.
Iloperidone Iloperidone The metabolism of Iloperidone can be increased when combined with Armodafinil.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Armodafinil.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Armodafinil.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Armodafinil.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Armodafinil.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Armodafinil.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be increased when combined with Armodafinil.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Armodafinil.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Armodafinil.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Armodafinil.
Asenapine Asenapine The metabolism of Asenapine can be increased when combined with Armodafinil.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Armodafinil.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Armodafinil.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Armodafinil.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Armodafinil.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Armodafinil.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Armodafinil.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Armodafinil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Armodafinil.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Armodafinil.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Armodafinil.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Armodafinil.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Armodafinil.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Armodafinil.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Armodafinil.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Armodafinil.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Armodafinil.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Armodafinil.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Armodafinil.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be increased when combined with Armodafinil.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Armodafinil.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Armodafinil.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Armodafinil.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be increased when combined with Armodafinil.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Armodafinil.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Armodafinil.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Armodafinil.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Armodafinil.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Armodafinil.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Armodafinil.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Armodafinil.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Armodafinil.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Armodafinil.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Armodafinil.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Armodafinil.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Armodafinil.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Armodafinil.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be increased when combined with Armodafinil.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Armodafinil.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Armodafinil.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Armodafinil.
Apremilast Apremilast The metabolism of Apremilast can be increased when combined with Armodafinil.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Armodafinil.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Armodafinil.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Armodafinil.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Armodafinil.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Armodafinil.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Armodafinil.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Armodafinil.
Methamphetamine Methamphetamine The risk or severity of hypertension can be increased when Metamfetamine is combined with Armodafinil.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Armodafinil.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Armodafinil.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Armodafinil.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be increased when combined with Armodafinil.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Armodafinil.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Armodafinil.
Haloperidol Injection Haloperidol Injection The metabolism of Haloperidol can be increased when combined with Armodafinil.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Armodafinil.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be increased when combined with Armodafinil.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Armodafinil.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Armodafinil.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Armodafinil.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Armodafinil.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Armodafinil.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Armodafinil.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Armodafinil.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Armodafinil.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Armodafinil.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Armodafinil.
Cobicistat Cobicistat The metabolism of Cobicistat can be increased when combined with Armodafinil.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Armodafinil.
Rucaparib Rucaparib The metabolism of Rucaparib can be increased when combined with Armodafinil.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Armodafinil.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Armodafinil.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Armodafinil.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be increased when combined with Armodafinil.
Valbenazine Valbenazine The metabolism of Valbenazine can be increased when combined with Armodafinil.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Armodafinil.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Armodafinil.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Armodafinil.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Armodafinil.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Armodafinil.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Armodafinil.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Armodafinil.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Armodafinil.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Armodafinil.
Lofexidine Lofexidine The metabolism of Lofexidine can be increased when combined with Armodafinil.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Armodafinil.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Armodafinil.
Doravirine Doravirine The metabolism of Doravirine can be increased when combined with Armodafinil.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Armodafinil.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Armodafinil.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Armodafinil.
Stiripentol Stiripentol The metabolism of Stiripentol can be increased when combined with Armodafinil.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Armodafinil.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Armodafinil.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Armodafinil.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Armodafinil.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Armodafinil.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Armodafinil.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Armodafinil.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Armodafinil.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Armodafinil.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Armodafinil.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Armodafinil.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Armodafinil.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Armodafinil.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Armodafinil.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Armodafinil.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Armodafinil.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Armodafinil.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Armodafinil.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Armodafinil.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Armodafinil.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Armodafinil.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Armodafinil.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Armodafinil.
Cenobamate Cenobamate The metabolism of Cenobamate can be decreased when combined with Armodafinil.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Armodafinil.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Armodafinil.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Armodafinil.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Armodafinil.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Armodafinil.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Armodafinil.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Armodafinil.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Armodafinil.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Armodafinil.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Armodafinil.
Trazodone Trazodone The metabolism of Trazodone can be increased when combined with Armodafinil.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Armodafinil.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Armodafinil.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Armodafinil.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Armodafinil.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Armodafinil.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Armodafinil.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Armodafinil.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Armodafinil.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Armodafinil.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Armodafinil.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Armodafinil.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Armodafinil.
Dapsone Dapsone The metabolism of Dapsone can be increased when combined with Armodafinil.
Oxycodone Oxycodone The metabolism of Oxycodone can be increased when combined with Armodafinil.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Armodafinil.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be increased when combined with Armodafinil.
Maprotiline Maprotiline The metabolism of Maprotiline can be increased when combined with Armodafinil.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Armodafinil.
Perphenazine Perphenazine The metabolism of Perphenazine can be increased when combined with Armodafinil.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Armodafinil.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Armodafinil.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Armodafinil.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Armodafinil.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Armodafinil.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Armodafinil.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Armodafinil.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Armodafinil.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Armodafinil.
Promethazine Promethazine The metabolism of Promethazine can be increased when combined with Armodafinil.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Armodafinil.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Armodafinil.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Armodafinil.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Armodafinil.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Armodafinil.
Desipramine Desipramine The metabolism of Desipramine can be increased when combined with Armodafinil.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Armodafinil.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Armodafinil.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Armodafinil.
Disopyramide Disopyramide The metabolism of Disopyramide can be increased when combined with Armodafinil.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Armodafinil.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Armodafinil.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Armodafinil.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Armodafinil.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Armodafinil.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Armodafinil.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be increased when combined with Armodafinil.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Armodafinil.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be increased when combined with Armodafinil.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Armodafinil.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Armodafinil.
Disulfiram Disulfiram The metabolism of Disulfiram can be increased when combined with Armodafinil.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Armodafinil.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Armodafinil.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Armodafinil.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Armodafinil.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Armodafinil.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Armodafinil.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Armodafinil.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Armodafinil.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Armodafinil.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Armodafinil.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be increased when combined with Armodafinil.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Armodafinil.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Armodafinil.
Alprazolam Alprazolam The metabolism of Alprazolam can be increased when combined with Armodafinil.
Triazolam Triazolam The metabolism of Triazolam can be increased when combined with Armodafinil.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Armodafinil.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Armodafinil.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Armodafinil.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Armodafinil.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Armodafinil.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Armodafinil.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Armodafinil.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Armodafinil.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Armodafinil.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Armodafinil.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Armodafinil.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Armodafinil.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Armodafinil.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Armodafinil.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Armodafinil.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Armodafinil.
Buspirone Buspirone The metabolism of Buspirone can be increased when combined with Armodafinil.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Armodafinil.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Armodafinil.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Armodafinil.
Clozapine Clozapine The metabolism of Clozapine can be increased when combined with Armodafinil.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Armodafinil.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be increased when combined with Armodafinil.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Armodafinil.
Felodipine Felodipine The metabolism of Felodipine can be increased when combined with Armodafinil.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Armodafinil.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Armodafinil.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Armodafinil.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Armodafinil.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Armodafinil.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Armodafinil.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Armodafinil.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be increased when combined with Armodafinil.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Armodafinil.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Armodafinil.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Armodafinil.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Armodafinil.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Armodafinil.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Armodafinil.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Armodafinil.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Armodafinil.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Armodafinil.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Armodafinil.
Saquinavir Saquinavir The metabolism of Saquinavir can be increased when combined with Armodafinil.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be increased when combined with Armodafinil.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Armodafinil.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Armodafinil.
Indinavir Indinavir The metabolism of Indinavir can be increased when combined with Armodafinil.
Ritonavir Ritonavir The metabolism of Ritonavir can be increased when combined with Armodafinil.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Armodafinil.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Armodafinil.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Armodafinil.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be increased when combined with Armodafinil.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Armodafinil.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Armodafinil.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Armodafinil.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Armodafinil.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Armodafinil.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Armodafinil.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Armodafinil.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Armodafinil.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Armodafinil.
Propafenone Propafenone The metabolism of Propafenone can be increased when combined with Armodafinil.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Armodafinil.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Armodafinil.
Finasteride Finasteride The metabolism of Finasteride can be increased when combined with Armodafinil.
Quetiapine Quetiapine The metabolism of Quetiapine can be increased when combined with Armodafinil.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Armodafinil.
Citalopram Citalopram The serum concentration of Citalopram can be increased when it is combined with Armodafinil.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Armodafinil.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Armodafinil.
Sildenafil Sildenafil The metabolism of Sildenafil can be increased when combined with Armodafinil.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Armodafinil.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Armodafinil.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Armodafinil.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Armodafinil.
Nateglinide Nateglinide The metabolism of Nateglinide can be increased when combined with Armodafinil.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Armodafinil.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Armodafinil.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists