Eletriptan

30 interactions 5 explained in plain English
Also sold as: Relpax
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Dihydroergotamine Nasal Spray Methylergonovine Dihydroergotamine Injection Amitriptyline Palonosetron Injection
4 Contraindicated 25 Major 1 Moderate
All (30) Contraindicated (4) Major (25) Moderate (1)

Contraindicated

Eletriptan Dihydroergotamine Injection DHE-45® Injection Increased risk of prolonged vasospastic reactions Details Eletriptan Dihydroergotamine Nasal Spray Migranal Increased risk of prolonged vasospastic reactions Details Eletriptan Ketoconazole Topical Extina® Foam Increased eletriptan exposure Details Eletriptan Methylergonovine Methergine Increased risk of prolonged vasospastic reactions Details

Major

Eletriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Eletriptan Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Eletriptan Sertraline Explained Increased risk of serotonin syndrome Details Eletriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Eletriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Eletriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Eletriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Eletriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Eletriptan Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Eletriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Eletriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Eletriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Eletriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Eletriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Eletriptan Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Eletriptan Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Eletriptan Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Eletriptan Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Eletriptan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Eletriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Eletriptan Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Eletriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Eletriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Eletriptan Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Eletriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Eletriptan Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.