Medication interaction hub

What Supplements Interact with Repaglinide?

Repaglinide brand names: Prandin, GlucoNorm. Every interaction below applies to the brands too.

256 Interactions 2 Major 215 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Repaglinide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Repaglinide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Repaglinide (Prandin, GlucoNorm) is taken right before meals to drop blood sugar quickly, and that speed is exactly why this list deserves real respect. Nearly everything on it also acts on blood sugar, usually pushing it lower still and raising the odds of a hypoglycemic crash, though a handful, niacin among them, pull the other way and blunt the drug. Two entries matter most: Siberian cocklebur, which has caused severe hypoglycemia in people who ate it, and activated charcoal, which can soak up repaglinide before it ever works.

A smaller cluster of seventeen ingredients interferes with how oral medicines get absorbed at all, so bulky fibers like glucomannan should be spaced well apart from your dose. Know the warning signs of low sugar, shakiness, sweating, confusion, and test more often when you add a supplement. Only two of the 256 entries rate major, but 215 sit at moderate, and for a glucose-lowering pill that is hardly background noise.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 215 Minor 39 No known interaction 1,196

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Repaglinide: Top Interactions at a Glance

The Repaglinide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Repaglinide Combinations Today

The Repaglinide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Guarana + Repaglinidei

Theoretically, taking guarana with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Ceylon Cinnamon + Repaglinidei

Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Cashew + Repaglinidei

Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Read the full interaction Moderate Likelihood Possible Blue-green Algae + Repaglinidei

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Repaglinidei

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Repaglinidei

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Repaglinide

All 1,452 ingredients in our database, ranked by severity — 256 with a Repaglinide interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Repaglinide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Guarana with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking guarana with antidiabetes drugs might interfere with blood glucose control.

Full Guarana + Repaglinide answer

Can you take Ceylon Cinnamon with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Full Ceylon Cinnamon + Repaglinide answer

Can you take Cashew with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Full Cashew + Repaglinide answer

Can you take Blue-green Algae with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.

Full Blue-green Algae + Repaglinide answer

Can you take Reishi Mushroom with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Full Reishi Mushroom + Repaglinide answer

Can you take Winter Cherry with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Repaglinide answer

Can you take Zeaxanthin with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Zeaxanthin + Repaglinide answer

Can you take Zizyphus with Repaglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Zizyphus + Repaglinide answer

Can you take Thyroid Extract with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Repaglinide answer

Can you take Anhydrous Crystalline Maltose with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose)...

Full Anhydrous Crystalline Maltose + Repaglinide answer

Can you take Agar with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Repaglinide answer

Can you take Algin with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Repaglinide answer

Can you take Apple Cider Vinegar with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Repaglinide answer

Can you take Black Psyllium with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Repaglinide answer

Can you take Blond Psyllium with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Repaglinide answer

Can you take Calea Zacatechichi with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.

Full Calea Zacatechichi + Repaglinide answer

Can you take Carob with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Repaglinide answer

Can you take Goji with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.

Full Goji + Repaglinide answer

Can you take Goli Apple Cider Vinegar Gummies with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (...

Full Goli Apple Cider Vinegar Gummies + Repaglinide answer

Can you take Karaya Gum with Repaglinide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Repaglinide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Repaglinide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Repaglinide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Repaglinide sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Repaglinide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Repaglinide through this category.

About Repaglinide

Repaglinide is an oral diabetes medicine used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Generic name: Repaglinide  ·  Brand names: Prandin, GlucoNorm.

See the full Repaglinide drug information

Related: does Repaglinide deplete any nutrients?

Repaglinide has 2 reported nutrient associations in the research literature — see the Repaglinide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Repaglinide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Repaglinide.

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Pharmacist Counseling Corner

Repaglinide & Supplements: Common Questions

What supplements interact with Repaglinide?
Our database currently documents 256 ingredients with a known Repaglinide interaction (2 major, 215 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 256. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Repaglinide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Repaglinide?
Plenty of supplements coexist fine with Repaglinide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Prandin have the same supplement interactions as Repaglinide?
Yes — Prandin, GlucoNorm all contain Repaglinide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Repaglinide deplete any vitamins or nutrients?
It might — Repaglinide has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Repaglinide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Repaglinide and my other medications?
This page covers Repaglinide against supplements and herbal ingredients. Checking Repaglinide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Repaglinide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.