Medication interaction hub

What Supplements Interact with Canagliflozin?

Canagliflozin brand name: Invokana. Every interaction below applies to the brands too.

256 Interactions 2 Major 215 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Canagliflozin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Canagliflozin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Canagliflozin (Invokana) lowers blood sugar, and that is precisely why this list deserves genuine care. Nearly every ingredient on it works on glucose one way or another: most can push it too low when stacked with the drug, while a few, niacin among them, raise it and work against the medicine. The two entries to understand first are Siberian cocklebur, which has caused dangerously low blood sugar in people, and activated charcoal, which can soak up the drug in the gut before it takes effect.

A smaller cluster of 17 ingredients interferes with the absorption of oral medicines generally, so space those well apart from your dose. Elsewhere, close glucose checks matter, since shakiness, sweating, or confusion can signal a drop. Only two of the 256 rate major, with 215 moderate and 39 minor, but the sheer weight of glucose effects gives this medication more to watch than most.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 215 Minor 39 No known interaction 1,196

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Canagliflozin: Top Interactions at a Glance

The Canagliflozin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Canagliflozin Combinations Today

The Canagliflozin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Alpha-lipoic Acid + Canagliflozini

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Acai + Canagliflozini

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Read the full interaction Minor Likelihood Unlikely Caffeine + Canagliflozini

Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Chromium + Canagliflozini

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Inositol + Canagliflozini

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Unlikely Blueberry + Canagliflozini

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Canagliflozin

All 1,452 ingredients in our database, ranked by severity — 256 with a Canagliflozin interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Canagliflozin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Full Alpha-lipoic Acid + Canagliflozin answer

Can you take Acai with Canagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Canagliflozin answer

Can you take Caffeine with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.

Full Caffeine + Canagliflozin answer

Can you take Chromium with Canagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Canagliflozin answer

Can you take Inositol with Canagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Full Inositol + Canagliflozin answer

Can you take Karaya Gum with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Canagliflozin answer

Can you take Maqui with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maqui + Canagliflozin answer

Can you take Marshmallow with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Canagliflozin answer

Can you take Moringa with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, moringa might have additive effects when used with antidiabetes drugs; however, research is conflicting.

Full Moringa + Canagliflozin answer

Can you take Puravive with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Canagliflozin answer

Can you take Stevia with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.

Full Stevia + Canagliflozin answer

Can you take Xanthan Gum with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Canagliflozin answer

Can you take Atkins Diet with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, following the Atkins diet might have additive hypoglycemic effects.

Full Atkins Diet + Canagliflozin answer

Can you take Black Tea with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Full Black Tea + Canagliflozin answer

Can you take Blueberry with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Blueberry + Canagliflozin answer

Can you take Chanca Piedra with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Chanca Piedra + Canagliflozin answer

Can you take Coconut with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.

Full Coconut + Canagliflozin answer

Can you take Coconut Water with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking coconut water with antidiabetes drugs might increase the risk of hypoglycemia.

Full Coconut Water + Canagliflozin answer

Can you take Coffee with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Full Coffee + Canagliflozin answer

Can you take Cola Nut with Canagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Full Cola Nut + Canagliflozin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Canagliflozin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Canagliflozin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Canagliflozin sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Canagliflozin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Canagliflozin through this category.

About Canagliflozin

Canagliflozin is a blood sugar–lowering medicine used to treat type 2 diabetes and to reduce serious risks of cardiovascular disease and kidney disease in adults who have those conditions alongside diabetes.

Generic name: Canagliflozin  ·  Brand name: Invokana.

See the full Canagliflozin drug information

Related: does Canagliflozin deplete any nutrients?

Canagliflozin has 1 reported nutrient association in the research literature — see the Canagliflozin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Canagliflozin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Canagliflozin.

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Pharmacist Counseling Corner

Canagliflozin & Supplements: Common Questions

What supplements interact with Canagliflozin?
In our interaction database, 256 supplement and herbal ingredients have an interaction with Canagliflozin on file — 2 rated major, 215 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Canagliflozin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Canagliflozin?
That depends entirely on which supplement. The honest answer for Canagliflozin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Invokana have the same supplement interactions as Canagliflozin?
Yes — Invokana all contain Canagliflozin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Canagliflozin deplete any vitamins or nutrients?
It might — Canagliflozin has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Canagliflozin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Canagliflozin and my other medications?
This page covers Canagliflozin against supplements and herbal ingredients. Checking Canagliflozin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Canagliflozin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.