Cashew - Invokana (Canagliflozin) Interaction

Interaction Details

Canagliflozin is classified as belonging to the following category: Antidiabetes Drugs

Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels. However, other evidence shows that eating 30 grams of cashew daily does not significantly affect glycemic measures. Until more is known, use with caution in combination with antidiabetes drugs. Theoretically, concomitant use might reduce the effects of antidiabetes drugs. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary.
Oral hypoglycemic drugs include glimepiride (Amaryl), glipizide (Glucotrol), glyburide (Diabeta, Micronase), tolazamide (Tolinase), tolbutamide (Orinase), and others.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Schutte, A. E., Van Rooyen, J. M., Huisman, H. W., Mukuddem-Petersen, J., Oosthuizen, W., Hanekom, S. M., and Jerling, J. C. Modulation of baroreflex sensitivity by walnuts versus cashew nuts in subjects with metabolic syndrome. Am.J Hypertens. 2006;19(6
• Mohan V, Gayathri R, Jaacks LM, et al. Cashew nut consumption increases HDL cholesterol and reduces systolic blood pressure in Asian Indians with Type 2 diabetes: A 12-week randomized controlled trial. J Nutr. 2018;148(1):63-69.

Canagliflozin Overview

• Canagliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in people with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Canagliflozin is also used to reduce the risk of stroke, heart attack, or death in people who have type 2 diabetes along with heart and blood vessel disease. Canagliflozin is also used to reduce the risk of end-stage kidney disease, worsening of kidney function, needing to be hospitalized for heart failure, and cardiovascular death in people who have type 2 diabetes along with severe kidney disease. Canagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Canagliflozin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood).

• Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Cashew - More Interactions

Cashew interacts with 84 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.