Drug & supplement interaction

Coconut + Canagliflozin

Canagliflozin brand name: Invokana.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Coconut has a minor interaction with Canagliflozin. Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Coconut and Canagliflozin

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Canagliflozin

Canagliflozin falls under ANTIDIABETES DRUGS — the group Coconut interacts with.

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: there's a theory that coconut, especially coconut milk in larger amounts, might nudge your blood sugar a little lower on its own. Stack that on top of Canagliflozin (Invokana), which already works to bring blood sugar down by helping your kidneys flush out extra sugar, and the worry is the two together could push your sugar lower than intended.

I want to be honest about how thin this evidence is. It comes from animal studies only, and the chance of it actually causing a problem is considered unlikely. Enjoying coconut in normal food amounts (a little oil, some shredded coconut, a splash of coconut milk) is very unlikely to matter. If you're using concentrated coconut products daily, just keep an eye out for low-sugar signs like shakiness, sweating, or dizziness, and check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coconut Also Interacts With Other Medications

Coconut has 85 minor known drug interactions in our database — the Canagliflozin one above is one of them. If you take anything else, check it against the full list below.

Minor 85 No known interaction 2,745 (incl. Canagliflozin)
Taking anything else?

Check Another of Your Medications Against Coconut

Covers the 2,830 medications we’ve checked against Coconut. Pick one to open its full report.

From our Q&A

Questions About Coconut or Canagliflozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coconut or Canagliflozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Canagliflozin

This page covers Coconut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Canagliflozin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Canagliflozin page

“Canagliflozin (Invokana) lowers blood sugar, and that is precisely why this list deserves genuine care. Nearly every ingredient on it works on glucose one way or another: most can push it too low when stacked with the drug, while a few, niacin among them, raise it and work against the medicine.”

Reviewed by 2 · Jul 18, 2026

Open the Canagliflozin interaction page

One more smart check

Taking Coconut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 806 real supplement products containing Coconut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut. Your product may carry other ingredients that interact with Canagliflozin too, on top of Coconut — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut and Canagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut
Top 25%

#174 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Canagliflozin
Steady interest

#1,934 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coconut

What is Coconut?

  • Skin and hair care
  • Source of dietary fats (MCTs)
  • Hydration with coconut water
  • Cooking and weight management
  • Antimicrobial (traditional use)

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) have reasonable support, many health claims for coconut oil are weak or unproven, and coconut oil is high in saturated fat. Talk with your pharmacist or doctor before using coconut products in large or medicinal amounts.

Read the full Coconut monograph & all interactions
Medication

About Canagliflozin

What Is Canagliflozin Used For?

Brand name: Invokana

Invokana (canagliflozin) is used alongside diet and exercise to improve blood sugar control in adults and children aged 10 and older with type 2 diabetes. It is not for type 1 diabetes.

In adults with type 2 diabetes, Invokana is also used to lower the risk of heart attack, stroke, and cardiovascular death in those with established cardiovascular disease, and to reduce the risk of serious kidney complications — including end-stage kidney disease, cardiovascular death, and hospitalization for heart failure — in those with diabetic kidney disease and high levels of protein in the urine.

See full Canagliflozin drug information
Keep checking

Other Drugs & Coconut

Browse every other medication we’ve checked against Coconut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
85Minor
2,744No known interaction
85 Minor 2,744 No interaction
Minor

85 interactions

Showing 60 of 85 minor interactions — see all 85 on the Coconut page.

No interaction 2,744 drugs checked — show the list

We also checked Coconut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Coconut list.

See the full Coconut interactions page
See every supplement checked against Canagliflozin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coconut monograph › Uses, safety, and every drug interaction in one place Canagliflozin supplement interactions › Every supplement checked against Canagliflozin, ranked by severity Canagliflozin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coconut and Canagliflozin Together: Common Questions

Can you take Coconut with Canagliflozin?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Coconut and Canagliflozin interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Canagliflozin and Coconut?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.