Herb & supplement monograph

Agrimony Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Agrimony interacts with medications. The heart of this page is the interaction list — every drug Agrimony is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Agrimony is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Agrimony against your medication

Add one medication

✓ Supplement

Agrimony

1 Your medication

Start typing any prescription or over-the-counter drug name.

Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Agrimony Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Agrimony drug interaction appears low for most people, though people taking diabetes medicines deserve extra care. Every listed interaction is rated moderate rather than major, and all of them rest on the same theoretical concern that has only been shown in animal research, not in people.

Interactions deserving the most attention

The one interaction worth real attention involves diabetes medications. Agrimony has lowered blood sugar in animal studies, so combining it with drugs that already lower blood sugar could, in theory, push levels too low. Because blood sugar is a closely monitored value where small shifts matter, anyone using insulin or other glucose-lowering medicines should treat this combination with some caution, even though the effect has not been confirmed in humans.

What the rest of the list means

Although a large number of medications appear on the interaction list, nearly all of them are there for this single reason: they affect blood sugar. That means the long list reflects one theoretical mechanism applied broadly, not dozens of separate proven problems, and no harmful interaction has actually been documented in people so far.

Check your medications against Agrimony

Based on HelloPharmacist’s Agrimony interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Agrimony

86 medications have a known interaction with Agrimony, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Agrimony using our pharmacist-reviewed interaction data.

AI summaries are generated from our Agrimony interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Agrimony combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Agrimony affects

Every type of medication (drug category) Agrimony is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Agrimony interacts with

Antidiabetes Drugs

Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.
Agrimony has demonstrated hypoglycemic effects in animal research.

Likelihood Possible Evidence D

Monograph

Agrimony: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Agrimony is a traditional European herb rich in tannins that has long been used for sore throats, mild diarrhea, and minor skin problems. Good-quality human studies are very limited, so its benefits remain unproven. If you choose to try it, use it short-term, follow the product label, and check with your pharmacist or doctor first.

Scientific name: Agrimonia eupatoria
Family: Rosaceae
Part used: Dried above-ground parts (leaves, stems, flowers) and seeds
Common forms: Tea, tincture, liquid extract, capsules, gargle or mouth rinse, topical preparations

People commonly use it for

Sore throat and mouth irritation
Mild diarrhea and digestive upset
Minor wounds and skin irritation
Gallbladder and liver complaints
Blood sugar support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally used in food-like amounts in tea, but human safety data are limited, so use with care.

PregnancyPossibly Unsafe

When used orally due to possible effects on the menstrual cycle.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable evidence; avoid use.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Agrimony (Agrimonia eupatoria) is a perennial herb in the rose family. It has tall spikes of small yellow flowers and toothed leaves, which is why it is sometimes called "church steeples" or "cocklebur." It grows wild across Europe, parts of Asia, and Africa.

The dried above-ground parts and seeds are used to make herbal teas, tinctures, and extracts. Agrimony has a long history in traditional European and folk medicine. People have used it as a tea to soothe a sore throat, as a gargle for mouth irritation, and to help with mild stomach and digestive complaints.

Uses & effectiveness

People traditionally use agrimony for sore throats, mild diarrhea, minor wounds, gallbladder and liver complaints, and to support blood sugar. Most of these uses come from long-standing folk traditions rather than strong scientific proof.

The evidence in humans is very limited. Most of what we know comes from laboratory and animal studies, which cannot tell us whether agrimony works or is safe for people. There are no large, high-quality clinical trials that clearly show agrimony treats any specific health condition.

Because of its tannin content, agrimony has a drying, astringent quality, which is the traditional reason it was used as a gargle or for mild diarrhea. This makes the traditional uses plausible, but it is not the same as proven effectiveness.

How it works

Agrimony contains a high amount of tannins (such as agrimoniin and other ellagitannins), along with flavonoids like luteolin-7-glucuronide, phenolic acids, terpenoids, and small amounts of coumarins. Tannins are astringent, meaning they can tighten and dry tissues, which may explain its traditional use for sore throats and mild diarrhea.

In test-tube and animal studies, agrimony extracts have shown antioxidant, anti-inflammatory, antimicrobial, and blood-sugar-lowering activity. These findings are preliminary and based mostly on laboratory research. They do not prove the herb produces the same effects in the human body.

Safety & precautions

Agrimony has been consumed as a tea for a long time, and small, food-like amounts are generally considered reasonably well tolerated. However, modern safety data from human studies are limited.

People with a known allergy to plants in the rose family should be cautious. Because of its tannins, large amounts taken over a long time may not be a good idea. People with diabetes, kidney, or liver conditions should talk to a healthcare provider before using it, since effects in these groups are not well understood.

Pregnancy and breastfeeding: There is not enough reliable information to consider agrimony safe during pregnancy or while breastfeeding. To be safe, it is best to avoid it during these times.

Always tell your pharmacist or doctor about any herbal product you take, especially if you have a medical condition or take prescription medicines.

Side effects

When used as a tea in moderate amounts, agrimony is usually well tolerated. The most likely side effects relate to its tannin content, such as stomach upset or constipation, especially with large doses.

Allergic skin reactions are possible, both from taking it and from applying it to the skin. Some plants in this family may make the skin more sensitive to sunlight. Stop using it and seek medical advice if you notice a rash, itching, swelling, or trouble breathing.

Dosing

There is no well-established, standardized dose for agrimony. Traditional use has been mainly as a tea made from the dried herb, or as a tincture or liquid extract.

If you choose to use an agrimony product, follow the directions on the label and do not exceed the recommended amount. Because product strength varies widely, it is a good idea to check with a pharmacist or doctor before starting, and to use it only for a short period.

Pregnancy & Breastfeeding

Agrimony & Pregnancy

Possibly Unsafe

When used orally due to possible effects on the menstrual cycle.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Agrimony & Breastfeeding

Insufficient reliable information

Insufficient reliable evidence; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Agrimony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Gray AM, Flatt PR. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. Br J Nutr 1998;80:109-14.
Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Agrimony

18 brands in our database make a supplement containing Agrimony.

BN Baseline Nutritionals 28 products Doctor Morse's Healing Herbs 47 products Dr. Morse's Cellular Botanicals 79 products Energetix 283 products Energique 31 products Flower Essence Services 386 products Genestra Brands 998 products Hawaii Pharm 4,726 products Health Concerns 444 products Herbal Terra 3,138 products Herbalist & Alchemist 613 products Maine Coast Herbals 33 products Nature's Sunshine 1,360 products Nature's Sunshine Flower Essence Formula 7 products Princess Lifestyle 23 products TerraVita 2,475 products TerraVita Premium Collection 4,019 products Vinco's 39 products

Product directory

Supplement products with Agrimony

75 products in our database contain Agrimony. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Agrimony: Common Questions

Does Agrimony interact with prescription medications?

Yes. We list 86 medications with a known interaction with Agrimony. Use the checker above to see how Agrimony interacts with a specific drug.

How are Agrimony interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Agrimony with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Agrimony interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Agrimony used for?

It is traditionally used as a tea or gargle for sore throats and mouth irritation, for mild diarrhea and stomach upset, for minor skin problems, and for liver, gallbladder, and blood sugar support. These uses come mostly from folk tradition, not strong scientific proof.

Is Agrimony safe to take?

Small amounts as a tea are generally considered reasonably well tolerated, but human safety data are limited. Use it short-term, follow the label, and check with your pharmacist or doctor first, especially if you have a health condition.

Can I take Agrimony while pregnant or breastfeeding?

No reliable safety information exists for these situations, so it is best to avoid Agrimony during pregnancy and breastfeeding.

Does Agrimony actually work?

Most evidence comes from laboratory and animal studies, not high-quality human trials. There is not enough proof to say it effectively treats any specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Agrimony

A rotating sample of real supplements in our database that list Agrimony — open any to see its full ingredients and every drug interaction we check.

See all 75 products with Agrimony →

Where next

Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Agrimony?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist