Drug & supplement interaction

Agrimony + Orphenadrine

Orphenadrine brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Agrimony and Orphenadrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Agrimony and Orphenadrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Orphenadrine and Agrimony in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Agrimony safety at a glance

Agrimony overall Use caution Generally used in food-like amounts in tea, but human safety data are limited, so use with care.
Pregnancy Possibly Unsafe When used orally due to possible effects on the menstrual cycle. Read the full pregnancy detail
Breastfeeding Avoid Safety while breastfeeding has not been studied, so avoid it to be cautious.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Orphenadrine and Agrimony? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Orphenadrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Orphenadrine is filed under 3 classifications — skeletal muscle relaxants, cytochrome p450 2b6 (cyp2b6) substrates, oral drugs. Agrimony has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Orphenadrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Agrimony Does Interact With Other Medications

Agrimony has 86 moderate known drug interactions in our database — Orphenadrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Orphenadrine)
Taking anything else?

Check Another of Your Medications Against Agrimony

Covers the 2,830 medications we’ve checked against Agrimony. Pick one to open its full report.

What to actually watch for

What Orphenadrine’s Own FDA Label Lists

This is not an interaction — none of it involves Agrimony. These are the most notable effects listed in the ADVERSE REACTIONS section of Orphenadrine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on
  • Confusion Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Tremor or shakiness
  • Blurred vision
  • A fast or pounding heartbeat
  • Drowsiness

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Orphenadrine. Read the label on DailyMed › Agrimony’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Agrimony side to compare — that is a limit of the record, not a statement that Agrimony has no side effects.

Special populations

Agrimony in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally due to possible effects on the menstrual cycle.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Agrimony or Orphenadrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Agrimony or Orphenadrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Orphenadrine

This page covers Agrimony only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Orphenadrine page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Adrafinil (moderate), African Wild Potato (moderate) and Artichoke (moderate).

By severity: 2 major · 22 moderate · 11 minor.

Open the Orphenadrine interaction page

One more smart check

Taking Agrimony as Part of a Dietary Supplement Product? Check It for Interactions

We hold 75 real supplement products containing Agrimony, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agrimony. Even though Agrimony itself has no known interaction with Orphenadrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Agrimony and Orphenadrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Agrimony
Top half

#552 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Orphenadrine
Steady interest

#1,819 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Agrimony reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Agrimony and Orphenadrine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Agrimony

What is Agrimony?

Agrimony
  • Sore throat and mouth irritation
  • Mild diarrhea and digestive upset
  • Minor wounds and skin irritation
  • Gallbladder and liver complaints
  • Blood sugar support

Agrimony is a traditional European herb rich in tannins that has long been used for sore throats, mild diarrhea, and minor skin problems. Good-quality human studies are very limited, so its benefits remain unproven. If you choose to try it, use it short-term, follow the product label, and check with your pharmacist or doctor first.

Agrimonia eupatoria · Rosaceae · Dried above-ground parts (leaves, stems, flowers) and seeds · Tea, tincture, liquid extract, capsules, gargle or mouth rinse, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Agrimony is a good idea for someone in your situation. Here is what our Agrimony record says about it on its own.

Agrimony: dosing

There is no well-established, standardized dose for agrimony. Traditional use has been mainly as a tea made from the dried herb, or as a tincture or liquid extract.If you choose to use an agrimony product, follow the directions on the label and do not exceed the recommended amount.

From our Agrimony monograph — the full record covers uses, side effects and every documented interaction.

Read the full Agrimony monograph & all interactions
Medication

About Orphenadrine

What Is Orphenadrine Used For?

Brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, Norflex Injection

Orphenadrine citrate is used to ease discomfort from acute, painful musculoskeletal conditions — things like muscle pain and stiffness. It is always used as part of a broader treatment plan that includes rest and physical therapy, not as a stand-alone cure.

Both the extended-release tablet and the injection form are approved for this use. Neither form directly relaxes tight muscles — the relief it provides is thought to be related to its pain-relieving (analgesic) properties.

See full Orphenadrine drug information
Keep checking

Other Drugs & Agrimony

Browse every other medication we’ve checked against Agrimony — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Agrimony page.

No interaction 2,743 drugs checked — show the list

We also checked Agrimony against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Agrimony list.

See the full Agrimony interactions page
See every supplement checked against Orphenadrine, ranked by severity
Evidence & sources

Agrimony References

The 4 references that drive our Agrimony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gray AM, Flatt PR. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. Br J Nutr 1998;80:109-14.
  4. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Agrimony and Orphenadrine Together: Common Questions

Is it safe to take Agrimony with Orphenadrine?
We do not list a known interaction between Agrimony and Orphenadrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Agrimony and Orphenadrine combination checked?
Interactions in our licensed database are recorded against drug classes. Orphenadrine is filed under 3 classifications, and Agrimony has documented interactions with 1 drug class — none of Orphenadrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Agrimony interact with any other medications?
Yes. Agrimony has 86 documented drug interactions in our database — Orphenadrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Orphenadrine interact with any supplements?
Yes. Orphenadrine has documented interactions with 35 supplements in our database — Agrimony is not one of them. The Orphenadrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Agrimony monograph Uses, safety profile, and every drug interaction in one place Orphenadrine drug information The full plain-English guide to this medication Orphenadrine supplement interactions Every supplement checked against Orphenadrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Orphenadrine and Agrimony?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.