Drug & supplement interaction

Agrimony + Linagliptin

Linagliptin brand name: Tradjenta.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Agrimony has a moderate interaction with Linagliptin. Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Agrimony and Linagliptin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Linagliptin

Linagliptin falls under ANTIDIABETES DRUGS — the group Agrimony interacts with.

Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.
Agrimony has demonstrated hypoglycemic effects in animal research.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Linagliptin (Tradjenta) already works to bring your blood sugar down. Agrimony has shown blood-sugar-lowering effects in animal studies, so the worry is that pairing the two could push your numbers a little too low. That's not a chemical clash in how Linagliptin is broken down. It's simply two things nudging blood sugar in the same direction at once.

I'll be honest, this is a theoretical concern based mostly on animal research, not solid human data, so I wouldn't lose sleep over it. Still, keep an eye out for signs of low blood sugar like shakiness, sweating, dizziness, or feeling unusually hungry, especially if you use agrimony regularly. Check with your pharmacist or doctor before combining them, and keep monitoring your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Gray AM, Flatt PR. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. Br J Nutr 1998;80:109-14.
  2. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Agrimony Also Interacts With Other Medications

Agrimony has 85 moderate known drug interactions in our database — the Linagliptin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Linagliptin)
Taking anything else?

Check Another of Your Medications Against Agrimony

Covers the 2,830 medications we’ve checked against Agrimony. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Linagliptin

This page covers Agrimony only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).

By severity: 3 major · 240 moderate · 41 minor.

From our pharmacist’s overview on the Linagliptin page

“Linagliptin (Tradjenta) helps people with type 2 diabetes bring blood sugar down, so most of the 284 supplements and herbs on this page interact for one basic reason: they lower glucose too, and stacking them can drop you into hypoglycemia. I'd read this list with genuine care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Linagliptin interaction page

One more smart check

Taking Agrimony as Part of a Dietary Supplement Product? Check It for Interactions

We hold 75 real supplement products containing Agrimony, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agrimony. Your product may carry other ingredients that interact with Linagliptin too, on top of Agrimony — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Agrimony and Linagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Agrimony
Top half

#544 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linagliptin
Top half

#1,085 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Agrimony

What is Agrimony?

Agrimony
  • Sore throat and mouth irritation
  • Mild diarrhea and digestive upset
  • Minor wounds and skin irritation
  • Gallbladder and liver complaints
  • Blood sugar support

Agrimony is a traditional European herb rich in tannins that has long been used for sore throats, mild diarrhea, and minor skin problems. Good-quality human studies are very limited, so its benefits remain unproven. If you choose to try it, use it short-term, follow the product label, and check with your pharmacist or doctor first.

Read the full Agrimony monograph & all interactions
Medication

About Linagliptin

What Is Linagliptin Used For?

Brand name: Tradjenta

Tradjenta (linagliptin) is used to help control blood sugar in adults with type 2 diabetes. It is meant to be used together with healthy eating and regular exercise, not as a replacement for them.

Linagliptin is not for type 1 diabetes, and it has not been studied in people with a history of pancreatitis.

See full Linagliptin drug information
Keep checking

Other Drugs & Agrimony

Browse every other medication we’ve checked against Agrimony — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Agrimony page.

No interaction 2,744 drugs checked — show the list

We also checked Agrimony against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Agrimony list.

See the full Agrimony interactions page
See every supplement checked against Linagliptin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Agrimony monograph › Uses, safety, and every drug interaction in one place Linagliptin supplement interactions › Every supplement checked against Linagliptin, ranked by severity Linagliptin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Agrimony and Linagliptin Together: Common Questions

Can you take Agrimony with Linagliptin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Agrimony and Linagliptin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Linagliptin and Agrimony?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.