Medication interaction hub

What Supplements Interact with Orphenadrine?

Orphenadrine brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, and others. Every interaction below applies to the brands too.

35 Interactions 2 Major 22 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Orphenadrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Orphenadrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

35 supplements and herbal ingredients have interactions with Orphenadrine on file in the HelloPharmacist interaction database — 2 rated major, 22 moderate, and 11 minor. The most serious involve Activated Charcoal and Procaine.

Our assessment: with 2 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Orphenadrine.

Major 2 Moderate 22 Minor 11 No known interaction 1,417

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Orphenadrine: Top Interactions at a Glance

The most significant Orphenadrine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 35 interacting ingredients — plus 1,417 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Orphenadrine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Orphenadrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Procaine + Orphenadrinei

Intravenous use of procaine hydrochloride is contraindicated.

Read the full interaction
The complete list

Every Supplement Checked Against Orphenadrine

All 1,452 ingredients in our database, ranked by severity — 35 with a Orphenadrine interaction on file and 1,417 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Orphenadrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ceylon Leadwort with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2B6 (CYP2B6) in vitro.

Full Ceylon Leadwort + Orphenadrine answer

Can you take Milk Thistle with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might inhibit CYP2B6.

Full Milk Thistle + Orphenadrine answer

Can you take Slippery Elm with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Orphenadrine answer

Can you take St. John's Wort with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Orphenadrine answer

Can you take Sweet Annie with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.

Full Sweet Annie + Orphenadrine answer

Can you take Tragacanth with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Orphenadrine answer

Can you take Thyroid Extract with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Orphenadrine answer

Can you take Agar with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Orphenadrine answer

Can you take Algin with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Orphenadrine answer

Can you take Black Psyllium with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Orphenadrine answer

Can you take Blond Psyllium with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Orphenadrine answer

Can you take Carob with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Orphenadrine answer

Can you take Ginger with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP2B6 substrates.

Full Ginger + Orphenadrine answer

Can you take Hibiscus Sabdariffa with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2B6 substrates.

Full Hibiscus Sabdariffa + Orphenadrine answer

Can you take Karaya Gum with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Orphenadrine answer

Can you take Marshmallow with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Orphenadrine answer

Can you take Xanthan Gum with Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Orphenadrine answer

Can you take Activated Charcoal with Orphenadrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Orphenadrine answer

Can you take Procaine with Orphenadrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Intravenous use of procaine hydrochloride is contraindicated.

Full Procaine + Orphenadrine answer

Can you take Coffee Charcoal with Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Orphenadrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Orphenadrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Orphenadrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Orphenadrine sits in 3 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Orphenadrine through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Orphenadrine through this category.

Skeletal Muscle Relaxants 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Orphenadrine through this category.

About Orphenadrine

Orphenadrine is a skeletal muscle relaxant used to relieve pain and discomfort from muscle strains, sprains, and injuries.

Generic name: Orphenadrine  ·  Brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, Norflex Injection.

See the full Orphenadrine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Orphenadrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Orphenadrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Orphenadrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Orphenadrine.

DNA Evolve by Complete Ascentials contains Procaine DNA Evolve by Complete Ascentials contains Procaine
Pharmacist Counseling Corner

Orphenadrine & Supplements: Common Questions

What supplements interact with Orphenadrine?
Our database currently documents 35 ingredients with a known Orphenadrine interaction (2 major, 22 moderate, 11 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 35. The highest-ranked right now: Activated Charcoal, Procaine, Coffee Charcoal.
Which Orphenadrine supplement interactions are the most serious?
The 2 major-rated combinations — led by Activated Charcoal and Procaine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Orphenadrine?
Plenty of supplements coexist fine with Orphenadrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Norflex have the same supplement interactions as Orphenadrine?
Yes — Norflex, Disipal, Banflex, Flexoject, Flexon and other brands all contain Orphenadrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Orphenadrine and my other medications?
This page covers Orphenadrine against supplements and herbal ingredients. Checking Orphenadrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Orphenadrine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.