Drug & supplement interaction

Rice Protein + Orphenadrine

Orphenadrine brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rice Protein and Orphenadrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rice Protein and Orphenadrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Orphenadrine and Rice Protein in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rice Protein safety at a glance

Rice Protein overall Generally safe Rice protein is generally considered safe for most healthy adults when used as a food.
Pregnancy Use caution Whole food rice is fine, but concentrated supplements are not well studied in pregnancy, so check with your provider first.
Breastfeeding Use caution Likely fine as a food, but concentrated protein supplements are not well studied while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Orphenadrine and Rice Protein? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Orphenadrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Orphenadrine is filed under 3 classifications — skeletal muscle relaxants, cytochrome p450 2b6 (cyp2b6) substrates, oral drugs. Rice Protein has documented interactions with 1 drug class — the most serious being ace inhibitors (aceis) (moderate) — and none of Orphenadrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rice Protein Does Interact With Other Medications

Rice Protein has 23 moderate known drug interactions in our database — Orphenadrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 23 No known interaction 2,807 (incl. Orphenadrine)
Taking anything else?

Check Another of Your Medications Against Rice Protein

Covers the 2,830 medications we’ve checked against Rice Protein. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rice Protein and Orphenadrine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Rice Protein

    “Orally, rice protein has been rarely reported to cause enterocolitis symptoms of vomiting, diarrhea, and dehydration, possibly leading to acidosis and lethargy, in infants and young children. Rarely, enterocolitis symptoms are associated with an allergy to rice protein.”

    Rice Protein · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 97806. Yasutomi M, Kosaka T, Kawakita A, et al. Rice protein-induced enterocolitis syndrome with transient specific IgE to boiled rice but not to retort-processed rice. Pediatr Int. 2014;56(1):110-2.
    2. 97811. Hojsak I, Kljaic-Turkalj M, Misak Z, Kolacek S. Rice protein-induced enterocolitis syndrome. Clin Nutr. 2006;25(3):533-6. PubMed

    Orphenadrine

    Listed in the ADVERSE REACTIONS section of the FDA label for Orphenadrine. Read the label on DailyMed ›

Reported for Rice Protein but not commonly for Orphenadrine: dehydration, diarrhea and tiredness.

Effects for Orphenadrine come from the ADVERSE REACTIONS section of its FDA label; effects for Rice Protein come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Rice Protein or Orphenadrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rice Protein or Orphenadrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Orphenadrine

This page covers Rice Protein only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Orphenadrine page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Adrafinil (moderate), African Wild Potato (moderate) and Artichoke (moderate).

By severity: 2 major · 22 moderate · 11 minor.

Open the Orphenadrine interaction page

One more smart check

Taking Rice Protein as Part of a Dietary Supplement Product? Check It for Interactions

We hold 610 real supplement products containing Rice Protein, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rice Protein. Even though Rice Protein itself has no known interaction with Orphenadrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rice Protein and Orphenadrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rice Protein
Top 25%

#337 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Orphenadrine
Steady interest

#1,477 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rice Protein reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rice Protein and Orphenadrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rice Protein

What is Rice Protein?

  • Building and maintaining muscle
  • Post-workout recovery
  • Plant-based protein source
  • Meal replacement and shakes
  • Weight management support

Rice protein is a plant-based protein powder made from rice that offers an easy way to add protein to your diet, especially if you avoid dairy or animal products. It is generally considered safe and well tolerated, though on its own it is lower in the amino acid lysine and is often blended with pea protein for a more complete amino acid profile. Talk to your pharmacist or doctor before using it if you have kidney problems or other health conditions.

Oryza sativa · Poaceae · Seed (grain/endosperm and bran) · Powder, protein shakes, capsules, blended plant-protein products

An interaction check asks whether these two react with each other — it does not ask whether Rice Protein is a good idea for someone in your situation. Here is what our Rice Protein record says about it on its own.

Rice Protein: dosing

There is no official standardized dose for rice protein. Serving sizes are usually based on how much protein you want to add to your diet, commonly around 20 to 30 grams of protein per scoop, but this varies by product.Always follow the directions on the product label and consider your total daily protein needs from all foods.

From our Rice Protein monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rice Protein monograph & all interactions
Medication

About Orphenadrine

What Is Orphenadrine Used For?

Brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, Norflex Injection

Orphenadrine citrate is used to ease discomfort from acute, painful musculoskeletal conditions — things like muscle pain and stiffness. It is always used as part of a broader treatment plan that includes rest and physical therapy, not as a stand-alone cure.

Both the extended-release tablet and the injection form are approved for this use. Neither form directly relaxes tight muscles — the relief it provides is thought to be related to its pain-relieving (analgesic) properties.

See full Orphenadrine drug information
Keep checking

Other Drugs & Rice Protein

Browse every other medication we’ve checked against Rice Protein — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
23Moderate
0Minor
2,806No known interaction
23 Moderate 2,806 No interaction
Moderate

23 interactions

No interaction 2,806 drugs checked — show the list

We also checked Rice Protein against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,806 medications checked with no known interaction — see the full Rice Protein list.

See the full Rice Protein interactions page
See every supplement checked against Orphenadrine, ranked by severity
Evidence & sources

Rice Protein References

The 6 references that drive our Rice Protein monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J 2013;12:86. PubMed
  2. Li GH, Qu MR, Wan JZ, You JM. Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac J Clin Nutr. 2007;16 Suppl 1:275-80.
  3. Reche M, Pascual C, Fiandor A, et al. The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577-85. PubMed
  4. Amended final report on the safety assessment of Oryza sativa (rice) bran oil, Oryza sativa (rice) germ oil, rice bran acid, Oryza sativa (rice) bran wax, hydrogenated rice bran wax, Oryza sativa (rice) bran extract, Oryza sativa (rice) extract, Oryza sat
  5. Yasutomi M, Kosaka T, Kawakita A, et al. Rice protein-induced enterocolitis syndrome with transient specific IgE to boiled rice but not to retort-processed rice. Pediatr Int. 2014;56(1):110-2.
  6. Hojsak I, Kljaic-Turkalj M, Misak Z, Kolacek S. Rice protein-induced enterocolitis syndrome. Clin Nutr. 2006;25(3):533-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rice Protein and Orphenadrine Together: Common Questions

Is it safe to take Rice Protein with Orphenadrine?
We do not list a known interaction between Rice Protein and Orphenadrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rice Protein and Orphenadrine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Rice Protein and Orphenadrine combination checked?
Interactions in our licensed database are recorded against drug classes. Orphenadrine is filed under 3 classifications, and Rice Protein has documented interactions with 1 drug class — none of Orphenadrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rice Protein interact with any other medications?
Yes. Rice Protein has 23 documented drug interactions in our database — Orphenadrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Orphenadrine interact with any supplements?
Yes. Orphenadrine has documented interactions with 35 supplements in our database — Rice Protein is not one of them. The Orphenadrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rice Protein monograph Uses, safety profile, and every drug interaction in one place Orphenadrine drug information The full plain-English guide to this medication Orphenadrine supplement interactions Every supplement checked against Orphenadrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Orphenadrine and Rice Protein?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.