Orphenadrine

26 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Glycopyrronium Topical Buprenorphine Lacosamide Injection Morphine Injection Midazolam Nasal Spray Nalbuphine Injection
24 Major 2 Moderate
All (26) Major (24) Moderate (2)

Major

Orphenadrine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Orphenadrine Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action, an increased risk of respiratory depression and CNS depression and an increased risk of pa... Details Orphenadrine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Orphenadrine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Orphenadrine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Orphenadrine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Orphenadrine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Orphenadrine Diazepam Rectal Diastat Increased risk of CNS depression Details Orphenadrine Esketamine Nasal Spray Spravato Increased risk of sedation Details Orphenadrine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of profound sedati... Details Orphenadrine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Orphenadrine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Orphenadrine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Orphenadrine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Orphenadrine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Orphenadrine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Orphenadrine Lacosamide Injection Motpoly An increased risk of CNS depression Details Orphenadrine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Orphenadrine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Orphenadrine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Orphenadrine Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Orphenadrine Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Orphenadrine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus, an increased risk of profound sedation, hypotension... Details Orphenadrine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details

Moderate

Orphenadrine Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details Orphenadrine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.