Medication interaction hub

What Supplements Interact with Chlorzoxazone?

Chlorzoxazone brand names: Parafon Forte DSC, Paraflex. Every interaction below applies to the brands too.

26 Interactions 2 Major 15 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorzoxazone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorzoxazone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Chlorzoxazone (Parafon Forte DSC, Paraflex) is a muscle relaxant for painful spasms, and its supplement list is one I want readers genuinely careful with. Twenty-six ingredients are on file, two rated major, led by activated charcoal, which can soak up the drug in the gut and cut what your body actually receives. Most of the 15 moderate entries fall into two patterns: bulky fibers and gums that slow or reduce absorption, and herbs that slow how the liver clears chlorzoxazone, like watercress, which raised its blood level by about half in a human study.

A higher level mostly means deeper drowsiness and dizziness, easy to miss until you are behind the wheel. The absorption issues are simpler; keep fibers, gums, and any charcoal product spaced well apart from your dose. Nine entries rate minor, but the two majors and the level-raising herbs are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 15 Minor 9 No known interaction 1,426

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Chlorzoxazone: Top Interactions at a Glance

The most significant Chlorzoxazone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 26 interacting ingredients — plus 1,426 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Chlorzoxazone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Chlorzoxazonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Procaine + Chlorzoxazonei

Intravenous use of procaine hydrochloride is contraindicated.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorzoxazone

All 1,452 ingredients in our database, ranked by severity — 26 with a Chlorzoxazone interaction on file and 1,426 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorzoxazone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Procaine with Chlorzoxazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Intravenous use of procaine hydrochloride is contraindicated.

Full Procaine + Chlorzoxazone answer

Can you take Algin with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Chlorzoxazone answer

Can you take Terminalia Chebula with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.

Full Terminalia Chebula + Chlorzoxazone answer

Can you take European Mandrake with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Chlorzoxazone answer

Can you take Glucomannan with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Chlorzoxazone answer

Can you take Lithium with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.

Full Lithium + Chlorzoxazone answer

Can you take Magnesium with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect...

Full Magnesium + Chlorzoxazone answer

Can you take Watercress with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects.

Full Watercress + Chlorzoxazone answer

Can you take Evodia with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might decrease the levels and clinical effects of chlorzoxazone.

Full Evodia + Chlorzoxazone answer

Can you take Guar Gum with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Chlorzoxazone answer

Can you take Gum Arabic with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Chlorzoxazone answer

Can you take Job's Tears with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Job's tears might enhance absorption of chlorzoxazone in the small intestine.

Full Job's Tears + Chlorzoxazone answer

Can you take Slippery Elm with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Chlorzoxazone answer

Can you take Terminalia with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.

Full Terminalia + Chlorzoxazone answer

Can you take Tragacanth with Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Chlorzoxazone answer

Can you take Thyroid Extract with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Chlorzoxazone answer

Can you take Agar with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Chlorzoxazone answer

Can you take Black Psyllium with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Chlorzoxazone answer

Can you take Blond Psyllium with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Chlorzoxazone answer

Can you take Carob with Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Chlorzoxazone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorzoxazone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorzoxazone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorzoxazone sits in 3 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorzoxazone through this category.

Chlorzoxazone (Parafon Forte, Paraflex) 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorzoxazone through this category.

Skeletal Muscle Relaxants 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Chlorzoxazone through this category.

About Chlorzoxazone

Chlorzoxazone is a muscle relaxer used to relieve pain and stiffness from muscle strains and sprains.

Generic name: Chlorzoxazone  ·  Brand names: Parafon Forte DSC, Paraflex.

See the full Chlorzoxazone drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorzoxazone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorzoxazone.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Chlorzoxazone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Chlorzoxazone.

DNA Evolve by Complete Ascentials contains Procaine DNA Evolve by Complete Ascentials contains Procaine
Pharmacist Counseling Corner

Chlorzoxazone & Supplements: Common Questions

What supplements interact with Chlorzoxazone?
Our database currently documents 26 ingredients with a known Chlorzoxazone interaction (2 major, 15 moderate, 9 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 26. The highest-ranked right now: Activated Charcoal, Procaine, Coffee Charcoal.
Which Chlorzoxazone supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Procaine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorzoxazone?
Plenty of supplements coexist fine with Chlorzoxazone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Parafon Forte DSC have the same supplement interactions as Chlorzoxazone?
Yes — Parafon Forte DSC, Paraflex all contain Chlorzoxazone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorzoxazone and my other medications?
This page covers Chlorzoxazone against supplements and herbal ingredients. Checking Chlorzoxazone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Chlorzoxazone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.