Medication interaction hub

What Supplements Interact with Dantrolene?

Dantrolene brand names: Dantrium, Dantrium Intravenous. Every interaction below applies to the brands too.

77 Interactions 5 Major 62 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dantrolene? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dantrolene against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take dantrolene (Dantrium) for muscle spasticity from multiple sclerosis or spinal cord injury, and the drug already carries a boxed warning for liver injury. That is why its supplement interactions deserve genuine respect. Thirty-eight of the 77 flagged ingredients can stress the liver themselves, and alcohol, whether beer or wine, sits among the five major-rated entries. Even ashwagandha, a favorite for stress and sleep, has been linked to liver failure in case reports.

The remaining risk splits three ways. Seventeen entries, activated charcoal chief among them, can blunt absorption of oral doses and should be spaced well apart. Twenty can add sun sensitivity, and a small handful may deepen the muscle-relaxing effect itself. Sixty-two of the 77 rate moderate and ten minor, but on a drug this hard on the liver, the hepatotoxic overlaps are the ones to sort out first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 62 Minor 10 No known interaction 1,375

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dantrolene: Top Interactions at a Glance

The most significant Dantrolene supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 77 interacting ingredients — plus 1,375 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dantrolene + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Dantrolenei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dantrolenei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Dantrolenei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Procaine + Dantrolenei

Intravenous use of procaine hydrochloride is contraindicated.

Read the full interaction Major Likelihood Probable Wine + Dantrolenei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Dantrolene

All 1,452 ingredients in our database, ranked by severity — 77 with a Dantrolene interaction on file and 1,375 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dantrolene?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ligandrol with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Dantrolene answer

Can you take Light Therapy with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Dantrolene answer

Can you take Lime with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Dantrolene answer

Can you take Manchurian Thorn with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Dantrolene answer

Can you take Niacin with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Dantrolene answer

Can you take Noni with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Dantrolene answer

Can you take Ostarine with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Dantrolene answer

Can you take Padang Cassia with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Dantrolene answer

Can you take Red Yeast Rice with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Dantrolene answer

Can you take Rhubarb with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Rhubarb + Dantrolene answer

Can you take Rue with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Dantrolene answer

Can you take Saigon Cinnamon with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Dantrolene answer

Can you take Slippery Elm with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Dantrolene answer

Can you take Spearmint with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Dantrolene answer

Can you take St. John's Wort with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Dantrolene answer

Can you take Sweet Annie with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Dantrolene answer

Can you take Sweet Clover with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Dantrolene answer

Can you take Syrian Rue with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Dantrolene answer

Can you take Testolone with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Dantrolene answer

Can you take Tragacanth with Dantrolene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Dantrolene answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dantrolene is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dantrolene, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dantrolene sits in 4 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Dantrolene through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Dantrolene through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dantrolene through this category.

Skeletal Muscle Relaxants 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dantrolene through this category.

About Dantrolene

Dantrolene is a skeletal muscle relaxant used to treat spasticity from neurological conditions and to manage or prevent malignant hyperthermia, a life-threatening reaction to certain anesthetics.

Generic name: Dantrolene  ·  Brand names: Dantrium, Dantrium Intravenous.

See the full Dantrolene drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dantrolene

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dantrolene.

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Pharmacist Counseling Corner

Dantrolene & Supplements: Common Questions

What supplements interact with Dantrolene?
More than you might expect — 77 in total, though they are far from equal: 5 are rated major, 62 moderate, and 10 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Dantrolene supplement interactions are the most serious?
The 5 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Procaine and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dantrolene?
Usually yes — most people on Dantrolene can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Dantrium have the same supplement interactions as Dantrolene?
Yes — Dantrium, Dantrium Intravenous all contain Dantrolene, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dantrolene and my other medications?
This page covers Dantrolene against supplements and herbal ingredients. Checking Dantrolene against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Dantrolene drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.