Pokeweed + Dantrolene
Dantrolene brand names: Dantrium, Dantrium Intravenous.
We found no known interaction between Pokeweed and Dantrolene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Pokeweed and Dantrolene
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dantrolene and Pokeweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pokeweed at all — not against Dantrolene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pokeweed safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pokeweed in Pregnancy & Breastfeeding
When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed is generally considered unsafe for any use.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Dantrolene
This page covers Pokeweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dantrolene page lists 77 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Procaine (major), Siberian Cocklebur (major) and Wine (major).
By severity: 5 major · 62 moderate · 10 minor.
From our pharmacist’s overview on the Dantrolene page
“People take dantrolene (Dantrium) for muscle spasticity from multiple sclerosis or spinal cord injury, and the drug already carries a boxed warning for liver injury. That is why its supplement interactions deserve genuine respect.”
Reviewed by 2 · Jul 18, 2026
Taking Pokeweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 12 real supplement products containing Pokeweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pokeweed. Even though Pokeweed itself has no known interaction with Dantrolene, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pokeweed and Dantrolene Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,165 of 1,452 supplements looked up here in the last 7 days
#2,346 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pokeweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pokeweed and Dantrolene records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pokeweed
What is Pokeweed?
- Joint pain and arthritis
- Skin conditions
- Swollen lymph nodes
- Respiratory complaints
- Traditional 'blood cleansing'
Pokeweed is a wild North American plant that is toxic in most of its raw forms, and there is no reliable evidence that it safely treats any condition. Poisonings have occurred from eating the berries, root, or improperly prepared greens. Because of its serious safety risks, most experts recommend avoiding it.
Phytolacca americana · Phytolaccaceae · Root, berries, leaves, and young shoots · Tincture, dried root, capsules, topical preparations, and traditionally cooked greens ('poke sallet')
An interaction check asks whether these two react with each other — it does not ask whether Pokeweed is a good idea for someone in your situation. Here is what our Pokeweed record says about it on its own.
Pokeweed: dosing
There is no established safe dose for pokeweed. Because the plant is toxic and the amount of active and harmful compounds varies widely, no reliable medicinal dose can be recommended.We do not provide dosing for pokeweed because of its poisoning risk. For most people, the safest choice is to avoid pokeweed altogether.
From our Pokeweed monograph — the full record covers uses, side effects and every documented interaction.
About Dantrolene
What Is Dantrolene Used For?
Brand names: Dantrium, Dantrium Intravenous
Dantrolene sodium capsules (Dantrium, Dantrolene Sodium) are used by mouth to control spasticity — painful or disabling muscle stiffness and spasms — caused by upper motor neuron disorders such as spinal cord injury, stroke, cerebral palsy, or multiple sclerosis. They are not used for muscle spasm from arthritis or other rheumatic conditions. Oral capsules are also used before and after surgery to prevent or reduce the risk of malignant hyperthermia in patients known to be susceptible.
For an active malignant hyperthermia crisis — a sudden, dangerous overheating of the muscles triggered by certain anesthetics — the intravenous (IV) forms are given in the hospital. Dantrium Intravenous, Revonto, Ryanodex, and Dantrolene injection are all indicated to treat a malignant hyperthermia crisis and may also be given before surgery to help prevent one in high-risk patients.
Other Drugs & Pokeweed
Browse every other medication we’ve checked against Pokeweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pokeweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amitriptyline ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pokeweed list.
Pokeweed References
The 7 references that drive our Pokeweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
- Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
- Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
- Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
- Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pokeweed and Dantrolene Together: Common Questions
Is it safe to take Pokeweed with Dantrolene?
Do Pokeweed and Dantrolene have any of the same side effects?
Does Dantrolene interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.