Drug & supplement interaction

Pokeweed + Clopidogrel

Clopidogrel brand name: Plavix.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pokeweed and Clopidogrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pokeweed and Clopidogrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clopidogrel and Pokeweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pokeweed at all — not against Clopidogrel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pokeweed safety at a glance

Pokeweed overall Avoid Pokeweed is toxic and has caused serious poisonings, so it is best avoided.
Pregnancy Likely Unsafe When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed i... Read the full pregnancy detail
Breastfeeding Likely Unsafe When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed i... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clopidogrel and Pokeweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Pokeweed Itself Has Been Linked To

This is not an interaction — nothing below involves Clopidogrel. It is the side-effect record for Pokeweed on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pokeweed, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Loss of vision / Seizures / Shortness of breath Worth acting on Additional detail

    “Pokeweed is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, all parts of the pokeweed plant can cause nausea, vomiting, cramping, abdominal pain, diarrhea, a burning sensation in the mouth and throat, weakness, hypotension, bloody emesis, bloody diarrhea, tachycardia, difficulty breathing, salivation, urinary incontinence, spasms, convulsions, severe thirst…”

    Pokeweed · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
    4. 3481. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
    5. 3482. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.
  • A low platelet count Worth acting on Additional detail

    “Orally and topically, pokeweed has been reported to cause plasmacytosis, mitotic changes in peripheral blood cells, eosinophilia, thrombocytopenia, abnormal platelet morphology, and other hematologic abnormalities. When used topically, these effects are more likely to occur in individuals with cuts or abrasions on the skin. Protective gloves should be used to handle the plant.”

    Pokeweed · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    4 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3481. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
    4. 3482. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.
  • Loss of bladder control Additional detail

    “Orally, all parts of the pokeweed plant can cause urinary incontinence.”

    Pokeweed · Natural Medicines adverse-effect record, reported in urinary incontinence.

    3 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
  • Increased thirst / Drowsiness Additional detail

    Recorded for Pokeweed in the same Natural Medicines adverse-effect record shown under Loss of vision / Seizures / Shortness of breath above.

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    “Orally, all parts of the pokeweed plant can cause hypotension and tachycardia.”

    Pokeweed · Natural Medicines adverse-effect record, reported in hypotension.

    3 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
  • Stomach pain Additional detail

    “Orally, all parts of the pokeweed plant can cause nausea, vomiting, cramping, abdominal pain, diarrhea, a burning sensation in the mouth and throat, bloody emesis, and bloody diarrhea.”

    Pokeweed · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed

Showing the 10 most notable of 13 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Pokeweed — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Clopidogrel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Clopidogrel column appears here.

Special populations

Pokeweed in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed is generally considered unsafe for any use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pokeweed or Clopidogrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pokeweed or Clopidogrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clopidogrel

This page covers Pokeweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clopidogrel page lists 309 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 258 moderate · 46 minor.

From our pharmacist’s overview on the Clopidogrel page

“Clopidogrel (Plavix) keeps platelets from sticking together after a stent, heart attack, or stroke, which makes this a list to take carefully. Of the 309 supplements and herbs on file, 202 carry blood-thinning or antiplatelet activity of their own and can stack bleeding risk on top of the drug's, while most of the rest change how the l…”

Reviewed by 2 · Jul 18, 2026

Open the Clopidogrel interaction page

One more smart check

Taking Pokeweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Pokeweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pokeweed. Even though Pokeweed itself has no known interaction with Clopidogrel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pokeweed and Clopidogrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pokeweed
Steady interest

#756 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clopidogrel
Top 1%

#14 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pokeweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pokeweed and Clopidogrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pokeweed

What is Pokeweed?

  • Joint pain and arthritis
  • Skin conditions
  • Swollen lymph nodes
  • Respiratory complaints
  • Traditional 'blood cleansing'

Pokeweed is a wild North American plant that is toxic in most of its raw forms, and there is no reliable evidence that it safely treats any condition. Poisonings have occurred from eating the berries, root, or improperly prepared greens. Because of its serious safety risks, most experts recommend avoiding it.

Phytolacca americana · Phytolaccaceae · Root, berries, leaves, and young shoots · Tincture, dried root, capsules, topical preparations, and traditionally cooked greens ('poke sallet')

An interaction check asks whether these two react with each other — it does not ask whether Pokeweed is a good idea for someone in your situation. Here is what our Pokeweed record says about it on its own.

Pokeweed: dosing

There is no established safe dose for pokeweed. Because the plant is toxic and the amount of active and harmful compounds varies widely, no reliable medicinal dose can be recommended.We do not provide dosing for pokeweed because of its poisoning risk. For most people, the safest choice is to avoid pokeweed altogether.

From our Pokeweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pokeweed monograph & all interactions
Medication

About Clopidogrel

What Is Clopidogrel Used For?

Brand name: Plavix

Clopidogrel tablets are used to reduce the risk of heart attack and stroke in people with acute coronary syndrome (ACS) — including unstable angina and non-ST-elevation or ST-elevation heart attacks — and in people with a history of recent heart attack, recent stroke, or established peripheral arterial disease. For ACS, it is typically given alongside aspirin.

It works by preventing platelets (blood cells that trigger clotting) from clumping together, which helps keep arteries open and lowers the chance of a dangerous clot forming.

Most-Reported Side Effects for Clopidogrel

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 10,950 reports
Myocardial infarction 10,227 reports
Fatigue 9,428 reports
Gastrointestinal haemorrhage 8,776 reports
Nausea 8,686 reports
See full Clopidogrel drug information
Keep checking

Other Drugs & Pokeweed

Browse every other medication we’ve checked against Pokeweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pokeweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pokeweed list.

See the full Pokeweed interactions page
See every supplement checked against Clopidogrel, ranked by severity
Evidence & sources

Pokeweed References

The 7 references that drive our Pokeweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
  4. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
  5. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
  6. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
  7. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pokeweed and Clopidogrel Together: Common Questions

Is it safe to take Pokeweed with Clopidogrel?
We do not list a known interaction between Pokeweed and Clopidogrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Clopidogrel interact with any supplements?
Yes. Clopidogrel has documented interactions with 309 supplements in our database — Pokeweed is not one of them. The Clopidogrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pokeweed monograph Uses, safety profile, and every drug interaction in one place Clopidogrel drug information The full plain-English guide to this medication Clopidogrel supplement interactions Every supplement checked against Clopidogrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clopidogrel and Pokeweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.