Medication interaction hub

What Supplements Interact with Clopidogrel?

Clopidogrel brand name: Plavix. Every interaction below applies to the brands too.

309 Interactions 5 Major 258 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Clopidogrel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Clopidogrel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Clopidogrel (Plavix) keeps platelets from sticking together after a stent, heart attack, or stroke, which makes this a list to take carefully. Of the 309 supplements and herbs on file, 202 carry blood-thinning or antiplatelet activity of their own and can stack bleeding risk on top of the drug's, while most of the rest change how the liver handles medicines. Grapefruit and St. John's wort are among the five rated major, one blocking the enzymes that process it, the other speeding them up.

Watch for unusual bruising, nosebleeds, or bleeding that is slow to stop, and report those promptly. Activated charcoal, another major entry, soaks up medicines in the gut, so keep it and bulky fiber supplements well apart from your dose. The other 258 entries rate moderate and 46 minor, less urgent individually, but on a drug protecting your heart, run each product past your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 258 Minor 46 No known interaction 1,143

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Clopidogrel: Top Interactions at a Glance

The Clopidogrel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 309 interacting ingredients — plus 1,143 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Clopidogrel Combinations Today

The Clopidogrel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Grape + Clopidogreli

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Cranberry + Clopidogreli

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Berberine + Clopidogreli

Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Read the full interaction Major Likelihood Probable Danshen + Clopidogreli

Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Rosemary + Clopidogreli

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Lion's Mane Mushroom + Clopidogreli

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Clopidogrel

All 1,452 ingredients in our database, ranked by severity — 309 with a Clopidogrel interaction on file and 1,143 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Clopidogrel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grape with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Full Grape + Clopidogrel answer

Can you take Cranberry with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Clopidogrel answer

Can you take Berberine with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Full Berberine + Clopidogrel answer

Can you take Danshen with Clopidogrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Clopidogrel answer

Can you take Rosemary with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Rosemary + Clopidogrel answer

Can you take Bismuth with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of bismuth subgallate or other bismuth salts might reduce the effects of anticoagulant/antiplatelet drugs.

Full Bismuth + Clopidogrel answer

Can you take Bitter Orange with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Clopidogrel answer

Can you take Black Currant with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Full Black Currant + Clopidogrel answer

Can you take Black Hoof Mushroom with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Full Black Hoof Mushroom + Clopidogrel answer

Can you take Black Pepper with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Clopidogrel answer

Can you take Black Seed with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.

Full Black Seed + Clopidogrel answer

Can you take Black Tea with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Clopidogrel answer

Can you take Blood Irradiation Therapy with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Clopidogrel answer

Can you take Bog Labrador Tea with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Clopidogrel answer

Can you take Boldo with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Boldo + Clopidogrel answer

Can you take Borage with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Clopidogrel answer

Can you take Boswellia Serrata with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Full Boswellia Serrata + Clopidogrel answer

Can you take Breadfruit with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Breadfruit + Clopidogrel answer

Can you take Broccoli with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.

Full Broccoli + Clopidogrel answer

Can you take Bromelain with Clopidogrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Clopidogrel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Clopidogrel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Clopidogrel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Clopidogrel sits in 7 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Clopidogrel through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Clopidogrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Clopidogrel through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Clopidogrel through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Clopidogrel through this category.

Clopidogrel (Plavix) 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Clopidogrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Clopidogrel through this category.

About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation.

Generic name: Clopidogrel  ·  Brand name: Plavix.

See the full Clopidogrel drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Clopidogrel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Clopidogrel.

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Pharmacist Counseling Corner

Clopidogrel & Supplements: Common Questions

What supplements interact with Clopidogrel?
More than you might expect — 309 in total, though they are far from equal: 5 are rated major, 258 moderate, and 46 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Danshen.
Which Clopidogrel supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Danshen, Piracetam and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Clopidogrel?
Usually yes — most people on Clopidogrel can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Plavix have the same supplement interactions as Clopidogrel?
Yes — Plavix all contain Clopidogrel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Clopidogrel and my other medications?
This page covers Clopidogrel against supplements and herbal ingredients. Checking Clopidogrel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Clopidogrel drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.