Medication interaction hub

What Supplements Interact with Agomelatine?

Agomelatine brand name: Valdoxan. Every interaction below applies to the brands too.

135 Interactions 1 Major 94 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Agomelatine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Agomelatine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

135 supplements and herbal ingredients have interactions with Agomelatine on file in the HelloPharmacist interaction database — 1 rated major, 94 moderate, and 40 minor. The most serious involve Activated Charcoal.

Our assessment: with 1 major-rated interaction on the list, this one deserves real attention — know the major entries before combining anything with Agomelatine.

Major 1 Moderate 94 Minor 40 No known interaction 1,317

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Agomelatine: Top Interactions at a Glance

The Agomelatine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 135 interacting ingredients — plus 1,317 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Agomelatine Combinations Today

The Agomelatine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Grape + Agomelatinei

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Rhodiola + Agomelatinei

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Probable Glucomannan + Agomelatinei

Theoretically, glucomannan may decrease absorption of drugs taken orally.

Read the full interaction Moderate Likelihood Possible Adrafinil + Agomelatinei

Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.

Read the full interaction Minor Likelihood Unlikely Rosemary + Agomelatinei

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Major Likelihood Probable Activated Charcoal + Agomelatinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Agomelatine

All 1,452 ingredients in our database, ranked by severity — 135 with a Agomelatine interaction on file and 1,317 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Agomelatine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grape with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Full Grape + Agomelatine answer

Can you take Rhodiola with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Full Rhodiola + Agomelatine answer

Can you take Glucomannan with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Agomelatine answer

Can you take Adrafinil with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.

Full Adrafinil + Agomelatine answer

Can you take Rosemary with Agomelatine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Full Rosemary + Agomelatine answer

Can you take Limonene with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction.

Full Limonene + Agomelatine answer

Can you take Mace with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzym...

Full Mace + Agomelatine answer

Can you take Methoxylated Flavones with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.

Full Methoxylated Flavones + Agomelatine answer

Can you take Neem with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.

Full Neem + Agomelatine answer

Can you take Nutmeg with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Full Nutmeg + Agomelatine answer

Can you take Oregon Grape with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.

Full Oregon Grape + Agomelatine answer

Can you take Panax Notoginseng with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Full Panax Notoginseng + Agomelatine answer

Can you take Parsley with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Agomelatine answer

Can you take Peony with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Agomelatine answer

Can you take Peppermint with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP2C19 substrates.

Full Peppermint + Agomelatine answer

Can you take Phellodendron with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.

Full Phellodendron + Agomelatine answer

Can you take Propolis with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.

Full Propolis + Agomelatine answer

Can you take Puravive with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme.

Full Puravive + Agomelatine answer

Can you take Quercetin with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2C9 substrates.

Full Quercetin + Agomelatine answer

Can you take Resveratrol with Agomelatine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.

Full Resveratrol + Agomelatine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Agomelatine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Agomelatine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Agomelatine sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Agomelatine through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Agomelatine through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Agomelatine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Agomelatine through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Agomelatine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Agomelatine through this category.

Related: does Agomelatine deplete any nutrients?

Agomelatine has 1 reported nutrient association in the research literature — see the Agomelatine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Agomelatine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Agomelatine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Agomelatine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Agomelatine.

Osteoherbal by Health Concerns contains Evodia Warm Cycle Teapills by Plum Flower contains Evodia Sugar Coated Gan Mao Ling by Plum Flower contains Evodia Mu Xiang Shun Qi Teapills by Plum Flower contains Evodia
Pharmacist Counseling Corner

Agomelatine & Supplements: Common Questions

What supplements interact with Agomelatine?
In our interaction database, 135 supplement and herbal ingredients have an interaction with Agomelatine on file — 1 rated major, 94 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Cannabidiol (cbd), Coffee Charcoal.
Which Agomelatine supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Agomelatine?
That depends entirely on which supplement. The honest answer for Agomelatine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Valdoxan have the same supplement interactions as Agomelatine?
Yes — Valdoxan all contain Agomelatine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Agomelatine deplete any vitamins or nutrients?
It might — Agomelatine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Agomelatine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Agomelatine and my other medications?
This page covers Agomelatine against supplements and herbal ingredients. Checking Agomelatine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.