Medication interaction hub

What Supplements Interact with Perampanel?

Perampanel brand name: Fycompa. Every interaction below applies to the brands too.

230 Interactions 9 Major 175 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Perampanel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Perampanel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Perampanel (Fycompa) is a seizure medicine that already causes drowsiness and dizziness on its own, which is why I treat this list of 230 interacting supplements with real care. Most entries do one of two things: they add to its sedating effect, as alcohol and kava do, or they change how the liver handles it. Grapefruit can push perampanel levels up, while St. John's wort can pull them down, and for an anti-seizure drug a falling level can mean a breakthrough seizure.

Nine entries carry a major rating, activated charcoal among them, with 175 moderate and 46 minor behind them. Many of the moderates work through the same liver enzymes at lower stakes, and fiber-like products such as glucomannan can blunt absorption of oral doses, so space those well apart. Read the nine major entries first; if you drink even socially, that alone is worth a talk with your pharmacist.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 175 Minor 46 No known interaction 1,222

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Perampanel: Top Interactions at a Glance

The Perampanel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 230 interacting ingredients — plus 1,222 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Perampanel Combinations Today

The Perampanel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Turpentine Oil + Perampaneli

There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP act...

Read the full interaction Major Likelihood Probable Kava + Perampaneli

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction Moderate Likelihood Possible 5-htp + Perampaneli

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Read the full interaction Moderate Likelihood Possible Lemon Balm + Perampaneli

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Perampaneli

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Minor Likelihood Unlikely Rosemary + Perampaneli

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Perampanel

All 1,452 ingredients in our database, ranked by severity — 230 with a Perampanel interaction on file and 1,222 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Perampanel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turpentine Oil with Perampanel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Perampanel answer

Can you take Kava with Perampanel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Perampanel answer

Can you take 5-htp with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Perampanel answer

Can you take Lemon Balm with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + Perampanel answer

Can you take 1,4-butanediol with Perampanel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Perampanel answer

Can you take Phellodendron with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Perampanel answer

Can you take Phenibut with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Perampanel answer

Can you take Pinellia Ternata with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Perampanel answer

Can you take Poria Mushroom with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Perampanel answer

Can you take Propolis with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.

Full Propolis + Perampanel answer

Can you take Puravive with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme.

Full Puravive + Perampanel answer

Can you take Quercetin with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2C9 substrates.

Full Quercetin + Perampanel answer

Can you take Rabdosia Rubescens with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Perampanel answer

Can you take Rauvolfia Vomitoria with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Perampanel answer

Can you take Resveratrol with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.

Full Resveratrol + Perampanel answer

Can you take Rhodiola with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Full Rhodiola + Perampanel answer

Can you take Rooibos with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2C19 substrates may increase the effects of CYP2C19 substrates.

Full Rooibos + Perampanel answer

Can you take Saffron with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Perampanel answer

Can you take Sage with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Perampanel answer

Can you take Sassafras with Perampanel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Perampanel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Perampanel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Perampanel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Perampanel sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Perampanel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Perampanel through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Perampanel through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Perampanel through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Perampanel through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Perampanel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Perampanel through this category.

About Perampanel

Perampanel is an antiepileptic medicine used to treat partial-onset seizures and primary generalized tonic-clonic seizures in people with epilepsy.

Generic name: Perampanel  ·  Brand name: Fycompa.

See the full Perampanel drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Perampanel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Perampanel.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Perampanel-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Perampanel.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Perampanel & Supplements: Common Questions

What supplements interact with Perampanel?
Our database currently documents 230 ingredients with a known Perampanel interaction (9 major, 175 moderate, 46 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 230. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Perampanel supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Perampanel?
Plenty of supplements coexist fine with Perampanel; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Fycompa have the same supplement interactions as Perampanel?
Yes — Fycompa all contain Perampanel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Perampanel and my other medications?
This page covers Perampanel against supplements and herbal ingredients. Checking Perampanel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Perampanel drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.