Drug & supplement interaction

Pellitory-of-the-wall + Perampanel

Perampanel brand name: Fycompa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pellitory-of-the-wall and Perampanel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pellitory-of-the-wall and Perampanel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Perampanel and Pellitory-of-the-wall in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pellitory-of-the-wall at all — not against Perampanel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pellitory-of-the-wall safety at a glance

Pellitory-of-the-w... overall Use caution Limited safety data and a high potential to trigger allergies in sensitive people.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Perampanel and Pellitory-of-the-wall? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Perampanel’s Own FDA Label Lists

This is not an interaction — none of it involves Pellitory-of-the-wall. These are the most notable effects listed in the ADVERSE REACTIONS section of Perampanel’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on mentioned in 24.3% of FDA reports for Perampanel
  • Unsteadiness Worth acting on
  • A severe skin reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Weight gain
  • Mood changes or irritability
  • Drowsiness mentioned in 6.8% of FDA reports for Perampanel
  • Blurred vision

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Perampanel. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,347 voluntary FDA FAERS reports for Perampanel that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pellitory-of-the-wall’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pellitory-of-the-wall side to compare — that is a limit of the record, not a statement that Pellitory-of-the-wall has no side effects.

Everything else you take

See Every Supplement That Interacts With Perampanel

This page covers Pellitory-of-the-wall only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Perampanel page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 175 moderate · 46 minor.

From our pharmacist’s overview on the Perampanel page

“Perampanel (Fycompa) is a seizure medicine that already causes drowsiness and dizziness on its own, which is why I treat this list of 230 interacting supplements with real care. Most entries do one of two things: they add to its sedating effect, as alcohol and kava do, or they change how the liver handles it.”

Reviewed by 2 · Jul 18, 2026

Open the Perampanel interaction page

One more smart check

Taking Pellitory-of-the-wall as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16 real supplement products containing Pellitory-of-the-wall, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pellitory-of-the-wall. Even though Pellitory-of-the-wall itself has no known interaction with Perampanel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pellitory-of-the-wall and Perampanel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pellitory-of-the-wall
Steady interest

#1,364 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Perampanel
Steady interest

#2,156 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pellitory-of-the-wall reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pellitory-of-the-wall and Perampanel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pellitory-of-the-wall

What is Pellitory-of-the-wall?

  • Urinary tract complaints
  • Kidney and bladder stones
  • Mild diuretic ('water pill') effect
  • Cough and sore throat
  • Minor wound care (traditional topical use)

Pellitory-of-the-wall is a wild plant traditionally used as a diuretic and for urinary and kidney complaints, but modern human studies are very limited and do not confirm these uses. It is best known as a strong allergen (its pollen triggers hay fever), so people prone to allergies should be careful. Talk to a pharmacist or doctor before using it.

Parietaria officinalis · Urticaceae · Aerial parts (leaves and stems) · Tea, liquid extract, tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Pellitory-of-the-wall is a good idea for someone in your situation. Here is what our Pellitory-of-the-wall record says about it on its own.

Pellitory-of-the-wall: dosing

There is no well-established or standardized dose for pellitory-of-the-wall. Traditional use as a tea or extract varies widely, and reliable dosing guidance from clinical research is not available.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Pellitory-of-the-wall monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pellitory-of-the-wall monograph & all interactions
Medication

About Perampanel

What Is Perampanel Used For?

Brand name: Fycompa

Perampanel — available as Fycompa and in generic forms — is used to treat partial-onset seizures (seizures that start in one area of the brain) in patients with epilepsy aged 4 years and older. Both the tablet and oral suspension forms carry this indication.

Perampanel tablets and oral suspension are also approved as add-on (adjunctive) therapy for primary generalized tonic-clonic seizures (grand mal seizures involving the whole brain at once) in patients with epilepsy aged 12 years and older. Fycompa oral suspension and tablet share both indications.

Most-Reported Side Effects for Perampanel

From FAERS, the FDA’s public side-effect reporting system (7,532 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 1,138 reports
Somnolence 513 reports
Aggression 499 reports
Dizziness 396 reports
Epilepsy 361 reports
See full Perampanel drug information
Keep checking

Other Drugs & Pellitory-of-the-wall

Browse every other medication we’ve checked against Pellitory-of-the-wall — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pellitory-of-the-wall against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pellitory-of-the-wall list.

See the full Pellitory-of-the-wall interactions page
See every supplement checked against Perampanel, ranked by severity
Evidence & sources

Pellitory-of-the-wall References

The 1 references that drive our Pellitory-of-the-wall monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pellitory-of-the-wall and Perampanel Together: Common Questions

Is it safe to take Pellitory-of-the-wall with Perampanel?
We do not list a known interaction between Pellitory-of-the-wall and Perampanel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Perampanel interact with any supplements?
Yes. Perampanel has documented interactions with 230 supplements in our database — Pellitory-of-the-wall is not one of them. The Perampanel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pellitory-of-the-wall monograph Uses, safety profile, and every drug interaction in one place Perampanel drug information The full plain-English guide to this medication Perampanel supplement interactions Every supplement checked against Perampanel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Perampanel and Pellitory-of-the-wall?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.