Drug & supplement interaction

Carqueja + Perampanel

Perampanel brand name: Fycompa.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Carqueja and Perampanel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Carqueja and Perampanel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Perampanel and Carqueja in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Carqueja safety at a glance

Carqueja overall Use caution Limited human safety data; use cautiously and discuss with a healthcare professional.
Pregnancy Avoid Traditionally avoided and possibly linked to effects on the uterus; do not use.
Breastfeeding Avoid No reliable safety information during breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Perampanel and Carqueja? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Perampanel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Perampanel is filed under 7 classifications — including cytochrome p450 2c19 (cyp2c19) substrates, cytochrome p450 2c9 (cyp2c9) substrates, cytochrome p450 1a2 (cyp1a2) substrates. Carqueja has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Perampanel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Carqueja Does Interact With Other Medications

Carqueja has 86 moderate known drug interactions in our database — Perampanel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Perampanel)
Taking anything else?

Check Another of Your Medications Against Carqueja

Covers the 2,830 medications we’ve checked against Carqueja. Pick one to open its full report.

What to actually watch for

What Perampanel’s Own FDA Label Lists

This is not an interaction — none of it involves Carqueja. These are the most notable effects listed in the ADVERSE REACTIONS section of Perampanel’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on mentioned in 24.3% of FDA reports for Perampanel
  • Unsteadiness Worth acting on
  • A severe skin reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Weight gain
  • Mood changes or irritability
  • Drowsiness mentioned in 6.8% of FDA reports for Perampanel
  • Blurred vision

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Perampanel. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,347 voluntary FDA FAERS reports for Perampanel that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Carqueja’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Carqueja side to compare — that is a limit of the record, not a statement that Carqueja has no side effects.

Everything else you take

See Every Supplement That Interacts With Perampanel

This page covers Carqueja only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Perampanel page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 175 moderate · 46 minor.

From our pharmacist’s overview on the Perampanel page

“Perampanel (Fycompa) is a seizure medicine that already causes drowsiness and dizziness on its own, which is why I treat this list of 230 interacting supplements with real care. Most entries do one of two things: they add to its sedating effect, as alcohol and kava do, or they change how the liver handles it.”

Reviewed by 2 · Jul 18, 2026

Open the Perampanel interaction page

One more smart check

Taking Carqueja as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Carqueja, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Carqueja. Even though Carqueja itself has no known interaction with Perampanel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Carqueja and Perampanel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Carqueja
Top half

#479 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Perampanel
Steady interest

#1,679 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Carqueja reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Carqueja and Perampanel records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Carqueja

What is Carqueja?

  • Digestive upset and bloating
  • Liver and gallbladder support
  • Blood sugar control
  • Weight loss
  • Anti-inflammatory

Carqueja is a South American herb traditionally used as a bitter tea for digestion, liver complaints, and blood sugar. Human evidence is very limited, so its benefits are not well proven. Because safety data are thin, it should be avoided in pregnancy and breastfeeding and used cautiously by everyone else.

Baccharis trimera · Asteraceae · Aerial parts (stems and winged branches) · Tea (infusion or decoction), tincture, capsules, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Carqueja is a good idea for someone in your situation. Here is what our Carqueja record says about it on its own.

Carqueja: dosing

There is no well-established standardized dose for carqueja. Traditional use is most often as a tea made from the dried aerial parts, but the strength of teas, tinctures, and capsules varies widely between products.The safest approach is to follow the directions on the product label and not exceed the suggested amount.

From our Carqueja monograph — the full record covers uses, side effects and every documented interaction.

Read the full Carqueja monograph & all interactions
Medication

About Perampanel

What Is Perampanel Used For?

Brand name: Fycompa

Perampanel — available as Fycompa and in generic forms — is used to treat partial-onset seizures (seizures that start in one area of the brain) in patients with epilepsy aged 4 years and older. Both the tablet and oral suspension forms carry this indication.

Perampanel tablets and oral suspension are also approved as add-on (adjunctive) therapy for primary generalized tonic-clonic seizures (grand mal seizures involving the whole brain at once) in patients with epilepsy aged 12 years and older. Fycompa oral suspension and tablet share both indications.

Most-Reported Side Effects for Perampanel

From FAERS, the FDA’s public side-effect reporting system (7,532 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 1,138 reports
Somnolence 513 reports
Aggression 499 reports
Dizziness 396 reports
Epilepsy 361 reports
See full Perampanel drug information
Keep checking

Other Drugs & Carqueja

Browse every other medication we’ve checked against Carqueja — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Carqueja page.

No interaction 2,743 drugs checked — show the list

We also checked Carqueja against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Carqueja list.

See the full Carqueja interactions page
See every supplement checked against Perampanel, ranked by severity
Evidence & sources

Carqueja References

The 2 references that drive our Carqueja monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Coelho MG, Reis PA, Gava VB, et al. Anti-arthritic effect and subacute toxicological evaluation of Baccharis genistelloides aqueous extract. Toxicol Lett 2004;154:69-80. PubMed
  2. Oliveira AC, Endringer DC, Amorim LA, et al. Effect of the extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice. J Ethnopharmacol 2005;102:465-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Carqueja and Perampanel Together: Common Questions

Is it safe to take Carqueja with Perampanel?
We do not list a known interaction between Carqueja and Perampanel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Carqueja and Perampanel combination checked?
Interactions in our licensed database are recorded against drug classes. Perampanel is filed under 7 classifications, and Carqueja has documented interactions with 1 drug class — none of Perampanel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Carqueja interact with any other medications?
Yes. Carqueja has 86 documented drug interactions in our database — Perampanel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Perampanel interact with any supplements?
Yes. Perampanel has documented interactions with 230 supplements in our database — Carqueja is not one of them. The Perampanel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Carqueja monograph Uses, safety profile, and every drug interaction in one place Perampanel drug information The full plain-English guide to this medication Perampanel supplement interactions Every supplement checked against Perampanel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Perampanel and Carqueja?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.