Drug & supplement interaction

Spotted Geranium + Perampanel

Perampanel brand name: Fycompa.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Spotted Geranium and Perampanel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Spotted Geranium and Perampanel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Perampanel and Spotted Geranium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Spotted Geranium at all — not against Perampanel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Spotted Geranium safety at a glance

Spotted Geranium overall Use caution Generally used in small amounts traditionally, but modern safety data are limited.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Perampanel and Spotted Geranium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Perampanel’s Own FDA Label Lists

This is not an interaction — none of it involves Spotted Geranium. These are the most notable effects listed in the ADVERSE REACTIONS section of Perampanel’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on mentioned in 24.3% of FDA reports for Perampanel
  • Unsteadiness Worth acting on
  • A severe skin reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Weight gain
  • Mood changes or irritability
  • Drowsiness mentioned in 6.8% of FDA reports for Perampanel
  • Blurred vision

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Perampanel. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,347 voluntary FDA FAERS reports for Perampanel that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Spotted Geranium’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Spotted Geranium side to compare — that is a limit of the record, not a statement that Spotted Geranium has no side effects.

Everything else you take

See Every Supplement That Interacts With Perampanel

This page covers Spotted Geranium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Perampanel page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 175 moderate · 46 minor.

From our pharmacist’s overview on the Perampanel page

“Perampanel (Fycompa) is a seizure medicine that already causes drowsiness and dizziness on its own, which is why I treat this list of 230 interacting supplements with real care. Most entries do one of two things: they add to its sedating effect, as alcohol and kava do, or they change how the liver handles it.”

Reviewed by 2 · Jul 18, 2026

Open the Perampanel interaction page

One more smart check

Taking Spotted Geranium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Spotted Geranium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Spotted Geranium. Even though Spotted Geranium itself has no known interaction with Perampanel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Spotted Geranium and Perampanel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Spotted Geranium
Steady interest

#982 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Perampanel
Steady interest

#1,679 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Spotted Geranium is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Spotted Geranium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Spotted Geranium and Perampanel records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Spotted Geranium

What is Spotted Geranium?

  • Diarrhea
  • Mouth and throat sores
  • Bleeding and wound care
  • Hemorrhoids
  • Sore throat gargle

Spotted Geranium (Geranium maculatum), also called wild geranium or cranesbill, is a North American woodland plant whose tannin-rich root has long been used in folk medicine as an astringent for diarrhea, minor bleeding, and mouth or throat irritation. Modern human studies are very limited, so its effectiveness is largely unproven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Geranium maculatum · Geraniaceae · Root and rhizome (sometimes the dried leaves) · Dried root, tea, tincture, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Spotted Geranium is a good idea for someone in your situation. Here is what our Spotted Geranium record says about it on its own.

Spotted Geranium: dosing

There is no established standard dose for Spotted Geranium. Traditional use involved teas, tinctures, and gargles made from the dried root, but amounts varied widely and were not standardized.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Spotted Geranium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Spotted Geranium monograph & all interactions
Medication

About Perampanel

What Is Perampanel Used For?

Brand name: Fycompa

Perampanel — available as Fycompa and in generic forms — is used to treat partial-onset seizures (seizures that start in one area of the brain) in patients with epilepsy aged 4 years and older. Both the tablet and oral suspension forms carry this indication.

Perampanel tablets and oral suspension are also approved as add-on (adjunctive) therapy for primary generalized tonic-clonic seizures (grand mal seizures involving the whole brain at once) in patients with epilepsy aged 12 years and older. Fycompa oral suspension and tablet share both indications.

Most-Reported Side Effects for Perampanel

From FAERS, the FDA’s public side-effect reporting system (7,532 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 1,138 reports
Somnolence 513 reports
Aggression 499 reports
Dizziness 396 reports
Epilepsy 361 reports
See full Perampanel drug information
Keep checking

Other Drugs & Spotted Geranium

Browse every other medication we’ve checked against Spotted Geranium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Spotted Geranium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Spotted Geranium list.

See the full Spotted Geranium interactions page
See every supplement checked against Perampanel, ranked by severity
Evidence & sources

Spotted Geranium References

The 1 sources that drive our Spotted Geranium monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Spotted Geranium is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Spotted Geranium and Perampanel Together: Common Questions

Is it safe to take Spotted Geranium with Perampanel?
We do not list a known interaction between Spotted Geranium and Perampanel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Perampanel interact with any supplements?
Yes. Perampanel has documented interactions with 230 supplements in our database — Spotted Geranium is not one of them. The Perampanel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Spotted Geranium monograph Uses, safety profile, and every drug interaction in one place Perampanel drug information The full plain-English guide to this medication Perampanel supplement interactions Every supplement checked against Perampanel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Perampanel and Spotted Geranium?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.