Perampanel

28 interactions 3 explained in plain English
Also sold as: FYCOMPA
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Injection Lacosamide Injection Buprenorphine Midazolam Injection Fentanyl Transdermal Patch Midazolam Nasal Spray
24 Major 4 Moderate
All (28) Major (24) Moderate (4)

Major

Perampanel Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Perampanel Abametapir Explained Increased exposure of CYP3A4 substrate Details Perampanel Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Perampanel Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Perampanel Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Perampanel Calcifediol Rayaldee Altered serum levels of calcifediol Details Perampanel Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Perampanel Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Perampanel Esketamine Nasal Spray Spravato Increased risk of sedation Details Perampanel Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Perampanel Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Perampanel Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Perampanel Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Perampanel Lacosamide Injection Motpoly An increased risk of CNS depression Details Perampanel Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Perampanel Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Perampanel Metoclopramide Injection Gimoti Increased risk of CNS depression Details Perampanel Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Perampanel Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Perampanel Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Perampanel Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Perampanel Nafcillin Injection Unipen® Injection Decreased plasma levels of perampanel Details Perampanel Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Perampanel Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Perampanel Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Perampanel Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Perampanel Levonorgestrel After banger Decreased contraceptive effectiveness Details Perampanel Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.