Perampanel

Name: Perampanel Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

28 interactions 3 explained in plain English

Also sold as: FYCOMPA

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Injection Lacosamide Injection Buprenorphine Midazolam Injection Fentanyl Transdermal Patch Midazolam Nasal Spray

24 Major 4 Moderate

All (28) Major (24) Moderate (4)

Moderate

Perampanel Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Perampanel Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Perampanel Levonorgestrel After banger Decreased contraceptive effectiveness Details Perampanel Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.